Sodyum Bikarbonat 8.4% Molar

A Comprehensive Medical Overview Sodium Bicarbonate 8.4% Molar, also known as Sodyum Bikarbonat 8.4% Molar in Turkish, is a vital medical product used in various clinical settings. This intravenous solution plays a crucial role in managing acid-base imbalances and other critical conditions. This article provides a detailed examination of its composition, uses, administration, and potential…

Dosage form

Pack size

Potency

%8.4 10X10Ml

Manufacturer

Origin

Generic Name (Ingredient)

Each 10 Ml. Bulb; Sodium Bicarbonate 840 Mg Water For Injection K.M. 10 Ml

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Description

Composition and Formulation

Sodium Bicarbonate 8.4% Molar is a sterile, nonpyrogenic, hypertonic solution of sodium bicarbonate in water for injection. Each 10 mL ampoule contains:

  • Active ingredient: 0.84 g Sodyum Bikarbonat
  • Excipient: Water for injection

The solution has a pH of approximately 7.0 to 8.5 and an osmolarity of about 2,000 mOsm/L, making it significantly hypertonic compared to plasma.

Clinical Applications

Sodium Bicarbonate 8.4% Molar is primarily used to correct severe metabolic acidosis in various clinical scenarios:

  1. Cardiac arrest: During resuscitation efforts, it helps counteract the severe acidosis that develops due to tissue hypoxia and anaerobic metabolism.
  2. Severe diabetic ketoacidosis: It may be used cautiously in cases where pH is extremely low (<6.9) and not responding to fluid and insulin therapy.
  3. Certain drug intoxications: It can be beneficial in managing overdoses of drugs such as tricyclic antidepressants or salicylates.
  4. Severe renal tubular acidosis: It helps correct the metabolic acidosis that can occur in this condition.
  5. Hyperkalemia: The alkalinizing effect can help shift potassium into cells, temporarily lowering serum potassium levels.

Dosage and Administration

The dosage of Sodyum Bikarbonat 8.4% Molar should be tailored to the individual patient’s needs based on their acid-base status, serum electrolytes, and clinical condition. Here are general guidelines:

  • Initial dose for adults: 1 mmol/kg (1 mL/kg) administered intravenously
  • Subsequent doses: 0.5 mmol/kg (0.5 mL/kg) at 10-minute intervals, guided by arterial blood gas analysis and clinical response

It is crucial to emphasize that this medication should only be administered intravenously and under close medical supervision.

Contraindications and Precautions

Sodium Bicarbonate 8.4% Molar should be used with caution or avoided in certain conditions:

  • Metabolic or respiratory alkalosis
  • Hypocalcemia
  • Hypokalemia
  • Severe pulmonary edema
  • Congestive heart failure
  • Severe renal impairment

Careful monitoring of acid-base status, serum electrolytes, and fluid balance is essential during treatment.

Side Effects and Adverse Reactions

While Sodyum Bikarbonat 8.4% Molar can be life-saving in appropriate situations, it is not without risks. Potential adverse effects include:

  1. Metabolic alkalosis
  2. Hypernatremia
  3. Hypokalemia
  4. Hyperosmolality
  5. Fluid overload
  6. Paradoxical intracellular acidosis
  7. Tissue necrosis if extravasation occurs

Sodyum Bikarbonat 8.4% Molar Storage

Sodium Bicarbonate 8.4% Molar should be stored at room temperature, below 25°C (77°F). It should be protected from light and excessive heat. The solution should be clear and free of particulate matter before use.

Research on Long-term Use

Long-term use of Sodyum Bikarbonat 8.4% Molar is generally not recommended due to the potential for serious electrolyte imbalances and other complications. Most clinical applications involve short-term use in acute settings. However, some studies have explored its chronic use in specific conditions:

  1. Chronic kidney disease: Some research suggests that oral sodium bicarbonate supplementation may slow the progression of chronic kidney disease and improve nutritional status in patients with metabolic acidosis.
  2. Exercise performance: There is ongoing research into the potential benefits of sodium bicarbonate supplementation for enhancing high-intensity exercise performance, although this typically involves oral formulations rather than the intravenous solution.
  3. Cancer therapy: Some studies are investigating the potential of sodium bicarbonate to alter the tumor microenvironment and enhance the efficacy of certain cancer treatments.

It’s important to note that these areas of research primarily involve oral sodium bicarbonate supplementation rather than the intravenous 8.4% molar solution, which is reserved for acute medical interventions.

Comparison with Other Treatments for Metabolic Acidosis

While Sodyum Bikarbonat 8.4% Molar is a common treatment for severe metabolic acidosis, other approaches may be used depending on the underlying cause and severity of the condition:

  1. Tris-hydroxymethyl aminomethane (THAM): An alternative buffer that may be preferred in certain situations, such as when sodium load is a concern.
  2. Carbicarb: A mixture of sodium carbonate and sodium bicarbonate that may produce less CO2 than sodium bicarbonate alone.
  3. Dichloroacetate: Used in some cases of lactic acidosis to stimulate pyruvate dehydrogenase and reduce lactate production.
  4. Renal replacement therapy: In severe cases, especially those associated with renal failure, dialysis may be necessary to correct acid-base imbalances.

Conclusion

Sodyum Bikarbonat 8.4% Molar is a potent medical intervention for managing severe metabolic acidosis in critical care settings. While it can be life-saving when used appropriately, its administration requires careful consideration of the patient’s overall clinical picture, close monitoring, and expertise in acid-base physiology. As with any powerful medical intervention, the benefits must be weighed against the potential risks, and its use should be guided by evidence-based protocols and expert clinical judgment.

Aspect Details
Composition 0.84 g Sodium Bicarbonate per 10 mL ampoule
Primary Uses Severe metabolic acidosis, cardiac arrest, drug intoxications
Dosage Initial: 1 mmol/kg IV; Subsequent: 0.5 mmol/kg IV at 10-min intervals
Administration Intravenous use only
Contraindications Metabolic alkalosis, severe pulmonary edema, hypocalcemia
Side Effects Metabolic alkalosis, hypernatremia, hypokalemia, fluid overload
Storage Below 25°C (77°F), protected from light
Long-term Use Generally not recommended; limited research in specific conditions
Alternatives THAM, Carbicarb, Dichloroacetate, Renal replacement therapy

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The information on this page is not intended to be a substitute for professional medical advice, diagnosis, or treatment. always seek the advice for your physician or another qualified health provider with any questions you may have regarding a medical condition. Always remember to

  1. Ask your own doctor for medical advice.
  2. Names, brands, and dosage may differ between countries.
  3. When not feeling well, or experiencing side effects always contact your own doctor.

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