Sodium Bicarbonate 8.4% Iv Infusion Icin Solution Iceren Ampul

Description

Composition

Each 10 ml ampoule contains 0.84 g of sodium bicarbonate, making it a hypertonic solution with a high concentration of bicarbonate and sodium ions.

Indications

Sodium Bicarbonate 8.4% is primarily used after cardiac arrest to normalize the body’s pH. During cardiac arrest, the body produces an excessive amount of acid, and the injection of sodium bicarbonate helps to neutralize this increased acid level.

Dosage and Administration

Sodium bicarbonate 8.4% IV Infusion Solution is administered under close medical supervision. It can be given by slow direct IV injection diluted in 5% glucose or by continuous infusion in 5% glucose.

Dosage for Metabolic Acidosis

• For severe metabolic acidosis:
  • Dosage calculation (if acid-base status is available): 0.2 x weight (kg) x base deficit.
  • Alternatively: HCO3 (mEq) required = 0.5 x weight (kg) x [24 – serum HCO3 (mEq/L)].
  • Moderate acidosis: 50 to 150 mEq sodium bicarbonate diluted in 1 L of D5W, infused at a rate of 1 to 1.5 L/hour during the first hour.
  • Severe acidosis: 90 to 180 mEq sodium bicarbonate diluted in 1 L of D5W, infused at a rate of 1 to 1.5 L/hour during the first hour.
  • If acid-base status is not available: 2 to 5 mEq/kg IV infusion over 4 to 8 hours; subsequent doses based on patient’s acid-base status.

Dosage for Urinary Alkalinization

• Usual adult dose: 50 to 150 mEq sodium bicarbonate diluted in 1 L of D5W, infused at a rate of 1 to 1.5 L/hour.

Consult with a healthcare professional before using Sodium Bicarbonate 8.4% to ensure its safety for you.

Contraindications

Sodium bicarbonate should not be used in the following situations:

• Kidney failure
• Metabolic or respiratory alkalosis
• Hypertension
• Edema
• Congestive heart failure
• History of kidney stones with potassium deficiency
• Low serum calcium levels
• Respiratory insufficiency
• Chlorine deficiency
• High serum sodium levels

Side Effects and Precautions

Inaccurate administration may induce hypernatremia and hypokalemia. Hypertonic solutions (greater than 1.4%) may cause venous irritation, and extravasation may lead to tissue necrosis. Accidental intra-arterial administration of the 8.4% preparation may cause shock or loss of an extremity.

Storage The product should be stored below 25°C.

Efficacy and Clinical Use

Sodium Bicarbonate 8.4% is primarily used after cardiac arrest to normalize the body’s pH by neutralizing excessive acid. The product is administered under close medical supervision, with dosages varying based on the condition treated. For resuscitation, an IV injection of 1 mmol/kg up to 100 mmol, every 3 to 5 minutes, titrated to a narrowing of the QRS complex and aiming for serum pH between 7.45 and 7.55, is given.

Potential Side Effects

Overly aggressive therapy with sodium bicarbonate can result in metabolic alkalosis (associated with muscular twitching, irritability, and tetany) and hypernatremia. Inadvertent extravasation during intravenous administration can lead to tissue necrosis.

Warnings Solutions containing sodium ions should be used with great care in patients with congestive heart failure, severe renal insufficiency, and in clinical states with edema.

Precautions The potentially large sodium loads given with bicarbonate require caution. The injection site should be monitored closely to avoid tissue necrosis and irritation from leakage.

Overdosage In the event of alkalosis, the bicarbonate should be stopped and managed according to the degree of alkalosis. 0.9% sodium chloride injection IV may be given; potassium may also be needed.

Contraindications

• Metabolic or respiratory alkalosis
• Hypocalcemia
• Hypoventilation
• Hypernatremia
• Hypertension
• Edema
• Congestive heart failure
• History of urinary calculi
• Potassium depletion or hypocalcemia
• Conditions requiring sodium intake restrictions (e.g., renal failure)

Consult with a healthcare professional before using Sodium Bicarbonate 8.4% to ensure its safety.

Sodium Bicarbonate 8.4% Benefits

Cardiac Arrest Sodium bicarbonate is used after cardiac arrest to normalize the body’s pH by neutralizing excessive acid.

Metabolic Acidosis Sodium bicarbonate treats metabolic acidosis, typically administered over 3 to 4 hours in an appropriate amount to correct body base deficit.

Urinary Alkalinization Sodium bicarbonate is used for urinary alkalinization, with the rate adjusted to maintain urinary pH above 7.5.

Prevention of Contrast-Induced Nephropathy Sodium bicarbonate can prevent contrast-induced nephropathy using the 1.26% polyfusor. Dosage: 3 ml/kg for one hour before contrast, then 1 ml/kg/hour during the procedure and for six hours after.

Resuscitation For resuscitation, Sodium Bicarbonate 8.4% is given as an IV injection of 1 mmol/kg up to 100 mmol, every 3 to 5 minutes, titrated to a narrowing of the QRS complex and aiming for serum pH between 7.45 and 7.55.

Hyperkalemia For hyperkalemia (with metabolic acidosis and volume depletion), sodium bicarbonate can be used as an IV injection: 50 ml (50 mmol) over 5 to 10 minutes, under ECG control.

Consult with a healthcare professional before using sodium bicarbonate to ensure its safety.

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Summary Table

Aspect	Details
Composition	Each 10 ml ampoule contains 0.84 g of sodium bicarbonate
Indications	Cardiac arrest, metabolic acidosis, urinary alkalinization, prevention of contrast-induced nephropathy, resuscitation, hyperkalemia
Dosage and Administration	Administered under close medical supervision by slow direct IV injection diluted in 5% glucose or continuous infusion in 5% glucose
Contraindications	Kidney failure, metabolic/respiratory alkalosis, hypertension, edema, congestive heart failure, history of kidney stones with potassium deficiency, hypocalcemia
Side Effects	Hypernatremia, hypokalemia, venous irritation, tissue necrosis, metabolic alkalosis
Storage	Below 25°C
Precautions	Monitor injection site closely to avoid tissue necrosis and irritation
Benefits	Normalizes pH after cardiac arrest, treats metabolic acidosis, urinary alkalinization, prevents contrast-induced nephropathy, used in resuscitation, treats hyperkalemia