Siprogut Plus Ear Drops

Siprogut Plus is a clear, colorless, slightly sat-like solution. The product is packaged with a 5 mL transparent bottle with a self-dropper and a white propylene cap. Siprogut Plus ear drops contain the active ingredients ciprofloxacin hydrochloride, a synthetic broad-spectrum, effective agent against bacteria, combined with dexamethasone, an anti-inflammatory corticosteroid. Siprogut Plus is used topically…

Pack size




Generic Name (Ingredient)

3.00 mg of ciprofloxacin (equivalent to 3.50 mg of ciprofloxacin HCl) and 1.00 mg of dexamethasone per 1 mL.

Assuming your emergency circumstances for this product, visit Urgent Quotation page. Besides, for any pharmaceutical questions, please ask us in the comments section.


It is applied by dropping it into the ear.

  • Active ingredient: contains 3.00 mg of ciprofloxacin (equivalent to 3.50 mg of ciprofloxacin HCl) and 1.00 mg of dexamethasone per 1 mL.
  • Excipients: Benzalkonium chloride, disodium EDTA, sodium chloride, disodium phosphate dihydrate, hydroxypropyl betacyclodextrin, polyvinyl alcohol, hydrochloric acid/sodium hydroxide, water for injection
Atc Public No Equivalent Code Type Unit Quantity Packing Production Location License Tar. Licence No
S02AA15 A16130 Generic Drug 5 ML 1 Manufactured 2015-04-15 2015/321
World Health Organization (WHO)
Basic Drug Children’s Essential Drug Neonatal Essential Medicine
Not on the list Not on the list Not on the list

Things to consider before using Siprogut Plus Ear Drops

Situations that should not be used


  • If you have a sensitivity (allergy) to dexamethasone, ciprofloxacin or other quinolone antibiotics or other substances in this product,
  • If you have an ear infection caused by herpes simplex, Varicella infections,
  • If you have an ear infection due to fungi,
  • If you have an infection caused by microorganisms called Mycobacterium tuberculosis, Mycobacterium leprae or Mycobacterium avium

Situations that should be used with caution


  • It should be taken into account that, as with other antibiotic-containing preparations, the use of this product can result in excessive growth of non-susceptible microorganisms, including bacteria and fungi.
  • If your disease does not improve after a week of treatment, it is recommended that you be re-evaluated by the doctor.
  • If your ear discharge still persists after complete treatment or if it repeats two or more times within six months, consult your doctor so that the underlying causes can be determined.
  • The administration of Siprogut Plus should be stopped as soon as skin rash or any other hypersensitivity symptoms appear.
  • If there are signs of inflammation of the beams (tendons) to which the muscles attach to the bones, the use of this type should be stopped from the moment the symptom first appears.

If these warnings apply to you, even in any period in the past, please consult your doctor.

Using while Driving

No studies have been conducted on the effect of the drug on the ability to use vehicles.

Important information about some of the auxiliary substances contained in Siprogut Plus

  • Since benzalconyuin chloride is an irritant, it can cause skin problems, especially when used in the ear.

Concomitant use with other drugs

There is no information that Siprogut Plus interacts with drugs. If you are currently using or have used any prescription or over-the-counter medication, please inform your doctor or pharmacist about them.

Food and beverage interactions

(Open/Full/Alcohol use cases) Due to the application path of Siprogut Plus, it is not affected by food and beverages.

How to use Siprogut Plus

Siprogut Plus is a drug used by instillation into the ear. Always take Siprogut Plus according to your doctor’s instructions. If you are unsure, consult your doctor or pharmacist.

The bottle should be used within 28 days after opening.

Wash your hands before and after using Siprogut PlusFor use, proceed as follows:

  1. Open the lid
  2. In the first application, discard the ring under the lid
  3. Screw the cover back completely and firmly. So, the membrane in the dropper is punctured, and the dropper begins to flow.
  4. Turn the bottle upside down, holding it between your thumb and middle fingers.
  5. With the light pressure, you will apply your index finger to the inverted bottle, and a drop of Siprogut will flow.
  6. After the external ear canal is cleaned and dried, the solution is dripped into the ear with a dropper.
  7. After the dripping process, wait at least 60 seconds in the supine position.
  8. If you use the drop for both ears, do the same for your other ear.
  9. After use, close the cap of the bottle tightly.
  10. If you use another ear drop; You should leave the search for a time of 10-15 minutes between successive applications.

Unless otherwise recommended by the doctor, it is used 2-3 times a day, 4 drops, for 7-10 days in middle ear infections. In external ear canal inflammations, it is used 2 times a day, 3 drops, for 7 days.

Use in Children and Infants

“Siprogut Plus” should not be used in children 6 months and younger. Adult dosage can be used in infants and children older than 6 months.

Use in the Elderly

The daily dose is the same as in adults.

Special Use Cases

Kidney/Liver failure:

It should not be used in patients with renal and hepatic insufficiency. If you have the impression that the effect of Siprogut ear drop is too strong or weak, talk to your doctor or pharmacist.

Overdose and Treatment

You can remove the Siprogut from your ear by washing it with warm water.

If you have used more than what you should use Siprogut, talk to a doctor or pharmacist.

If You Forget to Use It

As soon as you remember, drip a single dose. However, if the time for your next dose is near, ignore the forgotten dose and continue your normal treatment program with the next dose.

Do not take double doses to offset forgotten amounts.

Effects that may occur when treatment with Siprogut is terminated

  • Unless your doctor tells you otherwise, continue to take your medication for the time indicated, even if you feel well. Terminating the treatment of Siprogut Plus may cause your symptoms to reappear.

Pregnancy & Breastfeeding

Consult your doctor or pharmacist before using the drug. Siprogut Plus should not be used during pregnancy. If you notice that you are pregnant during your treatment, consult your doctor or pharmacist immediately.

During breastfeeding

Consult your doctor or pharmacist before using the drug. Unless recommended by your doctor, Siprogut Plus should be used with caution during breastfeeding.

Side Effects

Like all medications, people who are sensitive to the substances contained in Siprogut may have side effects.

If one of the following occurs, stop using Siprogut and inform your doctor IMMEDIATELY or contact the emergency department of the hospital closest to you:

  • Anaphylaxis (the body’s very severe response to allergy-causing substances, sudden hypersensitivity)
  • Laryngeal edema (swelling in the larynx)

These are all serious side effects. Urgent medical attention may be required. The following side effects are listed according to their prevalence:

  • Common: Less than one in 10 patients, but more than one in 100 patients.
  • Uncommon: Less than one in 100 patients, but more than one in 1,000 patients.
  • Infrequently: Less than one in 1,000 patients, but more than one in 10,000 patients.
  • Very rare: Less than one in 10,000 patients, but more than one in 10,000 patients.
  • Unknown: It cannot be predicted based on the available data.

If you notice any of the following, tell your doctor: Side effects are listed as shown in the following categories:


  • Ear discomfort
  • Earache


  • Candidiasis (thrush)
  • Pinching in the ears, tingling
  • Dizziness
  • Headache
  • Don’t cry
  • Decreased hearing
  • Tinnitus
  • Ear discharge
  • Ear itching
  • Fungal infection in the ear
  • Accumulation of precipitate (residual, residue, stolen) in the ear,
  • Vomiting
  • Changes in the sense of taste
  • Peeling on the skin
  • Erythematous (redness) rash
  • Obstruction of the tympanostomy tube (ear tube obstruction)
  • Irritability
  • Fatigue

Store Condition

Keep Siprogut Plus in the packaging and out of the reach of children. Store at room temperature below 25°C, protected from light. The product is sterile until it is opened. Siprogut Plus should be used within 28 days after the lid is opened.

Use in accordance with the expiration date. Do not use Siprogut Plus after the expiration date on the package.

Do not throw Siprogut Plus into city water or in the trash that you do not use to protect the environment. Consult your pharmacist about this.

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The information on this page is not intended to be a substitute for professional medical advice, diagnosis, or treatment. always seek the advice for your physician or another qualified health provider with any questions you may have regarding a medical condition. Always remember to

  1. Ask your own doctor for medical advice.
  2. Names, brands, and dosage may differ between countries.
  3. When not feeling well, or experiencing side effects always contact your own doctor.


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