Fraxiparine Subkutan Injection Solution 2850 Iu/0.3Ml

Fraxiparine, the brand name for nadroparin calcium, is a potent anticoagulant medication that belongs to the class of low-molecular-weight heparins (LMWHs). This injectable drug is widely used for the prevention and treatment of deep vein thrombosis (DVT) and pulmonary embolism, two potentially life-threatening conditions caused by blood clots. In this comprehensive article, we delve into…

Dosage form

Pack size


2850 Iu/0.3Ml 2X0.3Ml



Generic Name (Ingredient)

Nadroparin Calcium (Inn) 2850 Iu Axa (Equivalent To 7500 Icu Axa) In 0.3 Ml Injectable Sterile Solution (Equivalent To 1 Icu Axa, 0.38 Iu Axa)

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Fraxiparine is a subcutaneous injection that works by inhibiting the formation of blood clots. It achieves this by inactivating factor Xa, a crucial enzyme in the blood clotting cascade. By disrupting this process, Fraxiparine effectively reduces the risk of harmful clots forming in the body’s blood vessels.

Indications and Uses

Fraxiparine is primarily indicated for the following conditions:

Prevention and Treatment of Deep Vein Thrombosis (DVT)

One of the primary uses of Fraxiparine is to prevent and treat DVT, a condition characterized by the formation of blood clots in the deep veins, typically in the legs. DVT can lead to serious complications, such as pulmonary embolism, if the clots break off and travel to the lungs, blocking blood flow.

Prevention of Pulmonary Embolism

Fraxiparine is also used to prevent pulmonary embolism, a potentially life-threatening condition that occurs when a blood clot travels from the veins to the lungs, obstructing blood flow and oxygen supply.

Surgical Prophylaxis

Fraxiparine is commonly administered to patients undergoing general or orthopedic surgery, such as hip or knee replacements, to reduce the risk of DVT and pulmonary embolism during the postoperative period.

Unstable Angina and Myocardial Infarction

In addition to its primary uses, Fraxiparine is also employed in the treatment of unstable angina and myocardial infarction (heart attack) survivors, helping to prevent further complications.

Dosage and Administration

Fraxiparine is available in prefilled syringes with varying dosages, including:

  • 0.3 mL (ungraduated green syringes): 2,850 anti-Xa IU
  • 0.4 mL (ungraduated orange syringes): 3,800 anti-Xa IU
  • 0.6 mL (graduated brown syringes): 5,700 anti-Xa IU
  • 1 mL (graduated violet syringes): 9,500 anti-Xa IU

The specific dosage and administration schedule will be determined by your healthcare provider based on your individual condition, weight, and other factors.

Fraxiparine Injection Side Effects

Like all medications, Fraxiparine may cause side effects in some individuals. The most common side effect is bleeding, which can occur at the injection site or from surgical wounds. This is due to the medication’s ability to reduce blood clotting.Other potential side effects include:

  • Painful or prolonged erections (rare)
  • Osteopenia (reduced bone density with extended use)
  • Skin necrosis (rare)
  • Thrombocytosis (increased platelet count)
  • Severe immunologically-mediated thrombocytopenia (rare immune reaction affecting platelets)
  • Eosinophilia (abnormal increase in eosinophils, a type of white blood cell)
  • Calcinosis (rare calcium deposits at the injection site)
  • Transient elevation of liver transaminases (temporary liver enzyme elevation)

It is crucial to report any unusual or concerning side effects to your healthcare provider immediately.

Precautions and Contraindications

Fraxiparine should not be used in individuals with the following conditions:

  • Allergy to nadroparin calcium, heparin, or any of the ingredients listed in the leaflet
  • Previous history of thrombocytopenia (low blood platelet count) due to Fraxiparine use
  • Increased risk of bleeding
  • History of ulcers in the stomach or intestine, or a burst blood vessel in the brain
  • Infective endocarditis (infection of the heart lining)
  • Severe kidney failure (if being treated for a blood clot)

Additionally, it is essential to follow your healthcare provider’s instructions regarding Fraxiparine usage and never stop using the medication without consulting them first.

Interactions with Other Medications

Fraxiparine may interact with certain medications, including:

  • Adderall (amphetamine/dextroamphetamine)
  • Aspirin (low-strength)
  • Augmentin (amoxicillin/clavulanate)
  • Benadryl (diphenhydramine)
  • Claritin (loratadine)
  • CoQ10 (ubiquinone)
  • Cymbalta (duloxetine)
  • Fish Oil (omega-3 polyunsaturated fatty acids)

It is crucial to inform your healthcare provider about all medications, supplements, and vitamins you are taking to avoid potential interactions.

Pregnancy and Breastfeeding

Fraxiparine is sometimes needed during pregnancy and the postpartum period for individuals at high risk of DVT or with a history of venous thromboembolism, prosthetic heart valves, atrial fibrillation, left ventricular dysfunction, or a history of fetal loss. Fraxiparine does not cross the placenta, minimizing its impact on the baby, and the most common side effect for the mother is minor bruising at the injection site.

While breastfeeding, some mothers may experience changes in breast milk color, consistency, and taste, as well as nausea triggered during letdown and feelings of fatigue or being overwhelmed. If you have any concerns about using Fraxiparine during pregnancy or while breastfeeding, consult your healthcare provider for personalized advice.


Fraxiparine (nadroparin calcium) is a powerful anticoagulant medication that plays a crucial role in the prevention and treatment of deep vein thrombosis, pulmonary embolism, and other related conditions. Its effectiveness in disrupting the blood clotting cascade makes it an invaluable tool in the medical arsenal. However, it is essential to use Fraxiparine under the guidance of a healthcare professional and to be aware of potential side effects and interactions.

By understanding the intricacies of this medication, patients can make informed decisions and ensure safe and effective treatment.


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The information on this page is not intended to be a substitute for professional medical advice, diagnosis, or treatment. always seek the advice for your physician or another qualified health provider with any questions you may have regarding a medical condition. Always remember to

  1. Ask your own doctor for medical advice.
  2. Names, brands, and dosage may differ between countries.
  3. When not feeling well, or experiencing side effects always contact your own doctor.


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