Terbisil Cream (Terbizil)
The cream should be avoided on the mucous membrane of the eyes, nose, and mouth. When they get into the eyes, they must be washed with plenty of water and, if necessary, consult with a doctor. During treatment, general hygiene rules should be followed to avoid re-infection through underwear and shoes. The clinical effect is usually observed from the first days of treatment.
Irregular use or premature termination of treatment leads to a relapse of the disease. In the case when, after 2 weeks of treatment, improvement is not observed, the diagnosis and sensitivity of the pathogen to the drug should be checked.
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Release form, Composition, and Packaging
Outdoor cream 1% white or almost white, with a slight smell of almonds.
|Terbinafine hydrochloride||10 mg,|
|Which corresponds to the content of terbinafine||8.8 mg|
Auxiliary substances: Sodium hydroxide – 1.2 mg, gasoline alcohol – 10 mg, monostearat – 19 mg, cetylpalmitate – 20 mg, cetyl alcohol – 40 mg, cetostearyl alcohol <TA%, stearyl alcohol 40%) – 40 mg, polysorbat 60 – 61 mg, isopropylmiristat – 80 mg, water purified – 718.8 mg.
15 g – aluminum tubes (1) – cardboard packs.
Terbisil Cream Indications
— fungal skin infections caused by dermatophytes Trichophyton (T. rubrum, T. mentagrophytes, T. verrucosum, T. violaceum, T. interdigitale, T. tonsurans), Microsporum canis and gypseum, Epidermophyton floccosum;
— skin infections caused by yeast-like mushrooms, mainly Candida (e.g. Candida albicans);
— multi-colored (chop) lichen Pityriasis Versicolor caused by Pityrosporum orbiculare (Malassezia furfur).
For outdoor use. The duration of treatment depends on the nature and severity of the disease.
Adults and Children
After preliminary purification and drying of the affected surface, a therapeutic cream 1 – 2 t / day is applied to it with a thin layer, slightly rubbing it into the affected and adjacent healthy areas of the skin. In places of physiological folds of leather (areas under the mammary glands, inter-finger spaces, inter-sit and inguinal areas) it is desirable to cover gauze after applying cream, in particular, at night.
For dermatomycosis of the body and legs: cream is used 1 – 2 times/day; treatment duration is 1 – 2 weeks.
At dermatomycosis: apply 1 – 2 times/day; treatment duration is 2 – 4 weeks.
Skin candidiasis cream can be used up to 2 times/day; the duration of treatment is 1 – 2 weeks.
Multi-colored lichen cream can be used up to 2 times/day; the course of treatment is 2 weeks.
Terbinafine belongs to the group of allylamines, and has a wide range of antifungal effects. Active in relation to dermatophytes Trichophyton, Microsporum, and Epidermophyton, as well as yeast mushrooms, mainly Candida albicans, as well as in relation to Pityrosporum ovale – the causative agent of multi-colored lichen (Pityriasis Versicolor). Depending on the type of mushroom, the mushrooms of the genus Candida and their mycelial forms have fungicidal or fungistatic effects.
Inhibits mushrooms – epoxidase and violates the early stage of sterol biosynthesis, leading to an ergosterol deficiency, accumulation in the good cell, and dead cell. The fungicidal effect is observed already at low concentrations of the drug and is manifested in the effect on the synthesis and formation of the mushroom membrane.
The – epoxidase is not related to the P450 cytochrome system (CYP450), so terbinafine does not affect the metabolism of hormones and drugs whose metabolism is associated with CYP450.
Terbisil Cream Side effect
In rare cases, redness of the skin, itching, or burning sensation, requiring termination of treatment, occurs at the place of application of the cream.
- Breastfeeding period;
- Hypersensitivity to which – or of the components of the drug.
- With caution: During pregnancy, in childhood (due to the lack of sufficient clinical experience).
Pregnancy and lactation
During pregnancy, the drug can only be used if the intended benefit for the mother exceeds the potential risk for the fetus. Terbisil Cream Contradicted during breastfeeding. If it’s necessary and the treatment with Terbisil Cream during lactation should resolve the issue of stopping breastfeeding.
Application for liver function disorders
Data on the use of Terbisil Cream in patients with impaired liver function is not provided.
Application for kidney function disorders
Data on the use of Terbisil Cream in patients with impaired renal function is not provided.
Assigning the drug to elderly patients does not require dosage correction. and is prescribed in the same mode.
Application for children
Use with caution in childhood (Due to the lack of sufficient clinical experience).
To date, Terbisil Cream has not reported overdose cases. If the cream is accidentally ingested, nausea, loss of appetite, pain in the upper abdomen, and diarrhea are possible.
Treatment: activated charcoal, and if necessary, carry out symptomatic therapy.
The interaction of Terbisil Cream (Terbizil cream) with other drugs is unknown.
Store at a temperature of 15-30 ° C out of the reach of children.
Best before date
Do not use it after the expiry date stated on the package.
Terbizil cream manufacturer: GEDEON RICHTER Plc. (Hungary)
|Generic Name (Ingredient)||
1 G Of Cream Contains 10 Mg Of Terbinafine Hydrochloride.
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