Sibelium Tablet

Migraines are a debilitating neurological condition that affects millions worldwide. While various medications exist to alleviate acute migraine attacks, preventive therapies play a crucial role in reducing the frequency and severity of these episodes. One such prophylactic treatment is Sibelium, a calcium channel blocker with a unique mechanism of action.

Dosage form

Pack size


5 Mg



Generic Name (Ingredient)

Each Tablet Contains 5.89 Mg Of Flunarizine Hydrochloride Equivalent To 5 Mg Of Flunarizine.

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Composition and Mechanism

Each Sibelium tablet contains 5 mg of the active ingredient flunarizine, a selective calcium entry blocker. Unlike traditional calcium antagonists that target voltage-gated channels, flunarizine is believed to exert its effects through an intracellular mechanism, potentially by antagonizing calmodulin, a calcium-binding protein. This distinctive mode of action contributes to Sibelium’s efficacy in various neurological and vascular disorders.

Indications and Usage

Sibelium tablets are primarily prescribed for the prophylaxis of migraine in adults. Regular administration can significantly reduce the frequency and intensity of migraine episodes. Additionally, Sibelium has demonstrated efficacy in alleviating vertigo associated with inner ear and central nervous system disorders.

Dosage and Administration

The recommended dosage of Sibelium varies according to the patient’s age:

  • For adults aged 18 to 64 years: Two Sibelium tablets (10 mg) should be taken in the evening.
  • For adults aged 65 years and older: One Sibelium tablet (5 mg) should be taken in the evening.

It is crucial to adhere to the prescribed dosage and not exceed the recommended amount, as higher doses may increase the risk of adverse effects.

Aspect Details
Dosage (18-64 years) 2 tablets (10 mg) in the evening
Dosage (≥65 years) 1 tablet (5 mg) in the evening
Side Effects Somnolence, weight gain, muscle pain, fatigue, constipation, nausea, insomnia, rhinitis, increased appetite, depression, abdominal discomfort, mastalgia
Precautions Avoid driving or operating machinery until effects are known; monitor for mood changes; contraindicated in depressive illness and Parkinson’s disease
Benefits Reduces frequency and severity of migraine attacks; alleviates vertigo
Usage Prophylactic treatment for migraine in adults

Sibelium Tablet Side Effects and Precautions

Like any medication, Sibelium may cause adverse effects in some patients. Common side effects include somnolence, weight gain, muscle pain, fatigue, constipation, nausea, insomnia, rhinitis, increased appetite, depression, abdominal discomfort, and mastalgia (breast pain). Patients should exercise caution when driving or operating machinery until they understand how the medication affects them.

Sibelium is contraindicated in individuals with a history of depressive illness or Parkinson’s disease. Regular monitoring of behavior and mood changes is essential, as the medication may potentially induce or exacerbate depressive symptoms.

Mechanism of Action

Flunarizine, the active ingredient in Sibelium, is a selective calcium entry blocker with a distinct mechanism of action. Unlike traditional calcium channel blockers that target voltage-gated channels, flunarizine is believed to exert its effects through an intracellular mechanism, potentially by antagonizing calmodulin, a calcium-binding protein.

By inhibiting the influx of extracellular calcium into myocardial and vascular smooth muscle cells, flunarizine induces vasodilation of coronary and systemic arteries. This increased oxygen delivery to the myocardial tissue and reduced peripheral resistance contribute to its therapeutic effects in various conditions, including migraine prophylaxis, occlusive peripheral vascular disease, vertigo, and as an adjuvant in epilepsy therapy.

Pregnancy and Breastfeeding

Sibelium is generally not recommended during pregnancy due to potential risks to the developing fetus. Pregnant women should consult their healthcare providers before initiating any medication.

Similarly, breastfeeding mothers should exercise caution when taking Sibelium, as small amounts of the drug may be excreted in breast milk. It is advisable to discuss the risks and benefits with a healthcare professional before using Sibelium while breastfeeding.

Monitoring and Tracking Progress

Regular follow-up appointments with a healthcare provider are essential while taking Sibelium. Physicians will assess the patient’s response to the medication and monitor for any adverse effects or changes in symptoms.

Patients should keep track of their migraine frequency, duration, and severity to gauge the medication’s effectiveness. Additionally, monitoring lifestyle factors such as diet, sleep, stress levels, and exercise can provide valuable insights into the overall management of migraines.

After an initial treatment period, healthcare providers may recommend periodic breaks from Sibelium to evaluate the ongoing need for the medication and assess the patient’s response.

Alternative Therapies and Lifestyle Modifications

While Sibelium is an effective prophylactic treatment for migraines, various alternative therapies and lifestyle modifications can complement or, in some cases, replace pharmacological interventions.

Vitamins and supplements, such as magnesium, riboflavin (vitamin B2), coenzyme Q10, melatonin, and feverfew, have shown promising results in migraine prevention. Essential oils, like peppermint oil, may also provide relief for tension headaches.

Lifestyle changes, including regular exercise, yoga, relaxation training, and biofeedback techniques, can significantly reduce migraine frequency and severity when combined with medication or as standalone interventions.


Sibelium (flunarizine) tablets offer a unique and effective approach to migraine prophylaxis, with a distinct mechanism of action targeting intracellular calcium regulation. While its use requires careful monitoring and consideration of potential side effects, Sibelium has proven to be a valuable addition to the arsenal of preventive therapies for migraines. By working closely with healthcare providers and exploring complementary lifestyle modifications, individuals can achieve better control over this debilitating condition and improve their overall quality of life.


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The information on this page is not intended to be a substitute for professional medical advice, diagnosis, or treatment. always seek the advice for your physician or another qualified health provider with any questions you may have regarding a medical condition. Always remember to

  1. Ask your own doctor for medical advice.
  2. Names, brands, and dosage may differ between countries.
  3. When not feeling well, or experiencing side effects always contact your own doctor.


The truth is that when we’re sick, or worried about getting sick, the internet won’t help.

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Why you can't look for symptoms on the Internet

If diagnoses could be made simply from a textbook or an article on a website, we would all be doctors and treat ourselves. Nothing can replace the experience and knowledge of specially trained people. As in any field, in medicine there are unscrupulous specialists, differences of opinion, inaccurate diagnoses and incorrect test results.


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