Ronkotol Nebulizasyon Icin Inhalation Coz. Ic. Vial 5 Mg/2.5Ml

(1 customer review)

Ronkotol 5 mg/2.5 ml nebulization solution is a formulation containing salbutamol sulfate, indicated primarily for inhalation in the treatment of respiratory conditions commonly encountered within the United Kingdom. As a selective beta2-adrenergic receptor agonist, this medication is designed to provide rapid relief from bronchospasm and associated breathing difficulties. The following comprehensive medical article will detail Ronkotol’s compositional elements, pharmacological mechanism of action, established therapeutic applications, recommended administration guidelines, necessary precautions, and potential adverse effects relevant to its clinical use.

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Dosage form

Pack size

Potency

5 Mg/2.5Ml 20X2.5Ml

Manufacturer

Origin

Generic Name (Ingredient)

Each Single Dose Vial Contains 6.0 Mg Salbutamol Sulfate Equivalent To 5 Mg Salbutamol At 2.5 Ml.

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Description

Ronkotol 5 mg/2.5 ml is a nebulization solution for inhalation containing salbutamol sulfate, primarily used in the treatment of respiratory conditions. This medication belongs to the class of selective beta2-adrenergic receptor agonists, which are designed to provide quick relief from bronchospasm and breathing difficulties. The following comprehensive guide provides detailed information about Ronkotol’s composition, mechanism of action, therapeutic uses, administration guidelines, precautions, and potential side effects.

Composition and Formulation

Ronkotol is presented as a clear, colorless to almost colorless sterile solution contained in single-dose plastic vials (nebules). Each vial contains 2.5 ml of solution with the following composition:

  • Active ingredient: Each 2.5 ml contains 6.0 mg of salbutamol sulfate, equivalent to 5 mg of salbutamol

  • Inactive ingredients: Sodium chloride, sulfuric acid (for pH adjustment), and water for injection

The formulation is specifically designed for nebulization and should only be administered through inhalation using an appropriate nebulizer device.

Mechanism of Action

Bronchodilatory Effect

Salbutamol, the active ingredient in Ronkotol, functions as a selective beta2-adrenergic receptor agonist. When inhaled, it binds to beta2 receptors on the smooth muscle cells lining the bronchial passages, activating them and causing the airways to relax and dilate. This bronchodilation effect facilitates improved airflow to the lungs, making breathing easier for patients with respiratory conditions characterized by airway constriction.

Onset and Duration of Action

Salbutamol typically begins to work within 5 to 15 minutes after inhalation. Maximum improvement in pulmonary function usually occurs 60 to 90 minutes after treatment, and the bronchodilator activity has been observed to persist for 3 to 6 hours. This relatively rapid onset of action makes Ronkotol suitable for providing quick relief from acute bronchospasm episodes.

Therapeutic Indications

Ronkotol nebulization solution is indicated for the following conditions:

Asthma Management

The medication is used in the routine management of chronic bronchospasm unresponsive to conventional therapy and in the treatment of acute severe asthma. It helps relieve symptoms such as wheezing, coughing, chest tightness, and shortness of breath associated with asthma exacerbations.

COPD Treatment

For patients with chronic obstructive pulmonary disease (COPD), Ronkotol aids in alleviating symptoms including bronchospasms, breathing difficulties, and wheezing. It provides symptomatic relief by opening the constricted airways, though it is not a cure for the underlying condition.

Other Respiratory Conditions

The medication may also be used in other conditions characterized by reversible airway obstruction, providing temporary relief from bronchospasm and related symptoms.

Dosage and Administration

For Adults and Adolescents (12 years and older)

  • Initial dose: 2.5 mg (one vial of Ronkotol 2.5 mg/2.5 ml) administered via nebulization

  • Standard dose: 2.5 mg to 5 mg (one vial of Ronkotol 5 mg/2.5 ml) up to four times daily

  • Maximum dose: In severe cases, under strict medical supervision in a hospital setting, up to 40 mg per day may be administered

For Children (4-11 years)

  • Standard dose: 2.5 mg to 5 mg up to four times daily

For Children (Under 4 years)

  • Clinical efficacy in infants under 18 months is uncertain

  • Other pharmaceutical forms may be more appropriate for administration in children under 4 years old

  • Medical supervision is strongly recommended for this age group

Method of Administration

  1. The solution should only be administered via nebulization using an appropriate nebulizer device

  2. The medication should not be injected or swallowed

  3. Avoid contact of the solution or nebulized mist with the eyes

  4. Use the nebulizer in a well-ventilated room, as some of the mist may disperse into the air3

  5. The solution is typically used undiluted, but for extended administration (over 10 minutes), it may be diluted with sterile normal saline

Precautions and Warnings

General Precautions

  • If symptoms worsen despite treatment or if you need to use the medication more frequently than prescribed, consult your healthcare provider as this may indicate worsening of the underlying condition

  • The medication should not be used to prevent threatened miscarriage

  • Use with caution if you have hyperthyroidism (overactive thyroid gland)

  • Exclusively for inhalation use; do not inject or swallow the solution

Special Patient Populations

  • Pregnancy: Use only if prescribed by a doctor after evaluating risks and benefits

  • Breastfeeding: Salbutamol may pass into breast milk; use only under doctor’s supervision if breastfeeding

  • Cardiovascular conditions: Use with caution in patients with pre-existing heart conditions as beta-agonists can affect heart rate and blood pressure

  • Diabetes: Monitor blood glucose levels as salbutamol may affect glucose metabolism

Drug Interactions

  • Beta-blockers may antagonize the effects of salbutamol

  • MAO inhibitors and tricyclic antidepressants may potentiate the effects on the cardiovascular system

  • Xanthine derivatives (like theophylline) and steroids may have additive effects when used with salbutamol

Side Effects

Common Side Effects

  • Tremor, particularly in the hands

  • Headache

  • Increased heart rate (tachycardia)

  • Palpitations

  • Muscle cramps

Less Common Side Effects

  • Dizziness

  • Nausea

  • Irregular heartbeat

  • Hyperactivity

  • Sleep disturbances

  • Behavioral changes

Rare but Serious Side Effects

  • Allergic reactions (swelling of face, lips, tongue; difficulty breathing; itchy rash)

  • Lactic acidosis (very rare, but reported with nebulized salbutamol)

  • Significant decrease in blood potassium levels (hypokalemia)

  • Paradoxical bronchospasm (worsening of breathing symptoms after inhalation)

If you experience any severe or persistent side effects, seek medical attention immediately.

Storage and Handling

  • Store Ronkotol nebules in their original packaging, protected from light

  • Store at room temperature, not exceeding 25°C

  • Do not refrigerate or freeze

  • Keep out of reach of children

  • Do not use after the expiration date printed on the package

  • Discard any unused portion of an opened nebule immediately after use

Practical Usage Guidelines

Each nebule is designed for single use only. After opening a nebule, use it immediately and discard any remaining solution. The medication should be administered using a nebulizer device, which converts the liquid solution into a fine mist that can be inhaled into the lungs. Always follow your healthcare provider’s instructions regarding the frequency and duration of treatment.

Medication Information Table
Active Ingredient Salbutamol (as sulfate) 5 mg per 2.5 ml
Pharmaceutical Form Nebulization solution for inhalation
Primary Indications Asthma, COPD, reversible airway obstruction
Adult Dosage 2.5-5 mg up to four times daily
Pediatric Dosage (4-11 years) 2.5-5 mg up to four times daily
Administration Method Via nebulizer device only
Common Side Effects Tremor, increased heart rate, headache, muscle cramps
Key Precautions Not for injection/oral use; caution with heart conditions, diabetes, hyperthyroidism
Main Benefits Quick relief from bronchospasm; improvement in breathing; effective in acute asthma attacks
Storage Conditions Room temperature (below 25°C); protect from light
Contraindications Hypersensitivity to salbutamol or any component
Onset of Action 5-15 minutes after inhalation
Duration of Effect 3-6 hours

Conclusion

Ronkotol nebulization solution containing salbutamol is an effective medication for managing acute bronchospasm and providing symptomatic relief in patients with asthma and COPD. While the medication can significantly improve breathing and quality of life, it should be used according to prescribed guidelines, and any changes in efficacy or frequency of use should be discussed with a healthcare provider. Understanding the proper administration, potential side effects, and precautions associated with Ronkotol can help ensure safe and effective use of this medication.

Remember that this information is intended to supplement, not replace, the expertise and judgment of healthcare professionals. Always consult your doctor or pharmacist with any questions or concerns about using Ronkotol or any other medication.

1 review for Ronkotol Nebulizasyon Icin Inhalation Coz. Ic. Vial 5 Mg/2.5Ml

  1. Patience Tsegah

    Very good

    • Medical Guidance Center

      Hello there, this is Wikikenko.
      Ronkotol Nebulizasyon is a medicine that contains salbutamol solution. It is used to treat asthma and other breathing problems. It is taken by mouth through a device called a nebulizer.
      You should use Ronkotol Nebulizasyon under the direction of a physician1. Self-administration of medicines may have risks and benefits. You should consult your doctor before using this medicine by yourself.

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The information on this page is not intended to be a substitute for professional medical advice, diagnosis, or treatment. always seek the advice for your physician or another qualified health provider with any questions you may have regarding a medical condition. Always remember to

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  2. Names, brands, and dosage may differ between countries.
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