Colpotrophine Vaginal Soft Capsule

In the realm of women’s health, the Colpotrophine Vaginal Soft Capsule emerges as a significant medicinal product. This article provides a comprehensive overview of this medication, from its composition to usage, precautions, and benefits. Let’s delve into the world of Colpotrophine with a critical eye.

Dosage form

Pack size


0.01 G



Generic Name (Ingredient)

Colpotrophine? Vaginal Soft Capsule; As Active Ingredient Contains 10 Mg Promestrien.

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Colpotrophine Vaginal Soft Capsule is a medication that contains 10 mg of Promestrien as its active ingredient. It holds national authorization in several countries, including Italy, Romania, Portugal, France, and Malta. The manufacturer of this product is Laboratoire Theramex S.A.M, and in Italy, it is also linked with Ratiopharm Italia S.R.L.

Active Ingredient: Promestrien

At the core of Colpotrophine Vaginal Soft Capsule lies Promestrien. Also known as estradiol 3-propyl 17β-methyl diether, it serves as the medication’s active ingredient. This synthetic estrogen is used topically in a 1% cream formulation, primarily for the treatment of vaginal atrophy in women.

Promestrien is a unique compound. It is the 3-propyl and 17β-methyl diether of estradiol, and it does not convert into estradiol in the body. This lack of conversion results in minimal absorption and negligible systemic estrogenic effects. While not effective for conditions of cutaneous androgenization, it has been described as a tropic agent and antiseborrheic.

Moreover, when applied locally, such as on the vulva or in the vagina, Promestrien can enhance muscle tone through increased local blood circulation. This effect aids in combatting the signs and symptoms typically associated with vulvovaginal atrophy.

the Power of Colpotrophine

Colpotrophine Vaginal Soft Capsule finds its primary utility in conditions that benefit from the topical application of estrogen. This includes the treatment of atrophic vaginitis, a condition characterized by inflammation and thinning of the vaginal walls due to a decrease in estrogen levels.


For those prescribed Colpotrophine Vaginal Soft Capsule, understanding the proper usage is essential. Here are the steps to follow:

  • Wash your hands thoroughly before and after using the medicine.
  • Use this medication precisely as directed by your healthcare provider. Avoid exceeding the recommended dosage or prolonging its use.
  • The full effect of the estrogens may take up to four months to become apparent.
  • In the case of estradiol vaginal inserts or rings, they need replacement every three months or removal after three months.
  • For vaginal creams or suppositories, a plastic applicator is typically used. Detailed directions are provided with the medicine.

The exact method may vary depending on the specific dosage form. Always consult with a healthcare professional for precise instructions.


The onset of action for Colpotrophine Vaginal Soft Capsule can vary. The full effect of the estrogens may become apparent over a span of up to four months, though individual responses may differ. The time required depends on personal health conditions and the nature of the symptoms being treated.


Colpotrophine Vaginal Soft Capsule, powered by Promestrien, serves as a valuable tool for the treatment of various conditions. These include:

  • Vaginal Atrophy due to Estrogen Deficiency: Offering relief from inflammation and thinning of the vaginal walls, stemming from a decrease in estrogen levels.
  • Post-Labor, Post-Surgery, and Post-Physiotherapy Vulvar and Cervico-Vaginal Cicatrization: Assisting in the healing process following these procedures.

It is important to remember that the benefits of this medication can vary from person to person. Precise guidance from a healthcare professional is crucial. Please note that this information may not be entirely up-to-date or comprehensive, so always consult with a healthcare professional for accurate and personalized information.


The use of Colpotrophine Vaginal Soft Capsule comes with specific precautions. These include:

  • Allergy: Avoid this medication if you are allergic to any of its ingredients.
  • Use of Masculine Latex Condoms: Refrain from using this product if you are using masculine latex condoms.
  • Lactation: It is generally not recommended during lactation, except on the contrary advice of your healthcare provider.
  • Hormone-Dependent Cancers: Caution is advised for individuals with hormone-dependent cancers (such as breast and endometrial cancer).
  • Spermicidal Products: Avoid combining this medication with spermicidal products to prevent inactivation.
  • Regular Medical Examination: During treatment, regular medical check-ups are necessary. In the event of vaginal bleeding, seek immediate medical advice.

Please note that this information may not be entirely up-to-date or comprehensive. Always consult with a healthcare professional for the most accurate and personalized information.


In conclusion, Colpotrophine Vaginal Soft Capsule, with its active ingredient Promestrien, is a valuable asset in the realm of women’s health. Its effectiveness in addressing conditions related to estrogen deficiency and its topical application make it a significant choice for many women.

Disclaimer: While this medication holds significant promise, it is crucial to use it as directed by a healthcare professional and to be aware of potential side effects and precautions. Always rely on the counsel of a healthcare provider for the most precise and personalized guidance.

Parameter Colpotrophine Vaginal Soft Capsule
Active Ingredient Promestrien
Common Uses Atrophic Vaginitis, Vulvar and Cervico-Vaginal Cicatrization
Usage Topical application as directed
Onset of Action Up to four months
Benefits Relief from vaginal atrophy, aid in cicatrization
Precautions Allergy, use of masculine latex condoms, lactation, hormone-dependent cancers, spermicidal products, regular medical examination



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The information on this page is not intended to be a substitute for professional medical advice, diagnosis, or treatment. always seek the advice for your physician or another qualified health provider with any questions you may have regarding a medical condition. Always remember to

  1. Ask your own doctor for medical advice.
  2. Names, brands, and dosage may differ between countries.
  3. When not feeling well, or experiencing side effects always contact your own doctor.


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