Description
Active Ingredient
The active ingredient in Cineset is cinacalcet. Each tablet contains 60 mg of cinacalcet, equivalent to 66.12 mg of cinacalcet hydrochloride. Cinacalcet functions by modulating the levels of parathyroid hormone (PTH), calcium, and phosphorus in the body.
Uses
Cineset Film Tablet 60 Mg is primarily used to address conditions related to the parathyroid glands, which are small glands located in the neck responsible for PTH production. The primary indications for Cineset include:
- Secondary Hyperparathyroidism: This condition is common in adults with chronic kidney disease who require dialysis. In these patients, the parathyroid glands become overactive, leading to elevated levels of PTH.
- Hypercalcemia in Parathyroid Cancer: Cineset is used to lower high blood calcium levels in adults with parathyroid cancer.
- Primary Hyperparathyroidism: This condition involves excessive PTH production due to an overactive parathyroid gland. Cineset is used when surgical removal of the gland is not feasible.
Generic Availability
Yes, a generic version of Cineset Film Tablet 60 Mg is available, known as cinacalcet. Patients should consult their healthcare provider when considering generic alternatives to ensure they are informed about potential differences in effectiveness and side effects.
How to Take Cineset Film Tablet 60 Mg
Dosage: The starting dose is typically 30 mg, which may be adjusted to 60 mg based on the patient’s response and medical condition.
Timing: Cineset should be taken 1 to 3 hours before sexual activity, as applicable, although this instruction is context-specific and might relate to another usage protocol. It’s important to follow your doctor’s specific directions.
Frequency: This medication should not be taken more than once in a 24-hour period.
Method: The tablets should be swallowed whole with a full glass of water to avoid a bitter taste.
These are general instructions. Always follow the specific directions provided by your healthcare provider to ensure the medication’s effectiveness and minimize side effects.
Side Effects
Cineset Film Tablet 60 Mg, which contains cinacalcet, may cause a range of side effects. While not everyone will experience these, they can vary in severity and may require medical attention.
More Common Side Effects
- Blurred vision
- Chest pain
- Dizziness
- Headache
- Nervousness
- Pounding in the ears
- Slow or fast heartbeat
Less Common Side Effects
- Convulsions
- Cough or hoarseness
- Fever or chills
- Loss of bladder control
- Lower back or side pain
- Muscle spasm or jerking of all extremities
- Painful or difficult urination
- Sudden loss of consciousness
Other Side Effects
- Diarrhea
- Lack or loss of strength
- Loss of appetite
- Nausea
- Vomiting
- Weight loss
Patients should report any side effects to their healthcare provider. Severe or persistent side effects necessitate immediate medical attention.
Drug Interactions
Cinacalcet is metabolized by the enzyme CYP3A4. If a patient starts or stops taking a strong CYP3A4 inhibitor, the dose of Cineset may need adjustment. Inform your healthcare provider about all medications, supplements, and herbal products you are taking to prevent potential interactions.
Food Interactions
Cineset Film Tablet 60 Mg should be taken with food or shortly after a meal to enhance absorption and effectiveness.
Timing After Meals
While Cineset Film Tablet 60 Mg should generally be taken with food or shortly after eating, patients should follow their healthcare provider’s specific advice regarding meal timing.
Concurrent Medication Use
Cineset can be taken with other medications, but potential drug interactions must be monitored. Since cinacalcet is metabolized by CYP3A4, dose adjustments might be necessary when taken with strong CYP3A4 inhibitors.
Examples of Strong CYP3A4 Inhibitors
- Clarithromycin: An antibiotic for bacterial infections.
- Telithromycin: Used for certain types of pneumonia.
- Nefazodone: An antidepressant.
- Itraconazole: An antifungal medication.
- Ketoconazole: Another antifungal.
- Atazanavir: Used for HIV treatment.
- Darunavir: An antiretroviral for HIV/AIDS.
- Indinavir: Another HIV medication.
- Lopinavir: Used in HIV treatment.
- Nelfinavir: An HIV treatment.
- Ritonavir: Commonly used in HIV/AIDS treatment.
- Saquinavir: Another HIV medication.
- Tipranavir: Used in combination with ritonavir for HIV.
This list is not exhaustive. Consult your healthcare provider for comprehensive advice and information based on your specific health condition and medication regimen.
Driving Safety
Some side effects of Cineset, such as dizziness, blurred vision, and fainting, may impair the ability to drive. Patients should assess how they feel after taking the medication and avoid driving if these side effects occur.
Precautions
Contraindications
Cineset should not be started if serum calcium levels are below the normal range, as it lowers serum calcium and can lead to hypocalcemia.
Warnings
Patients with a history of seizures should inform their doctors, as the risk of seizures may be higher with Cineset use.
Administration
Cineset tablets should be taken with food or shortly after a meal. The tablets must be swallowed whole and not chewed.
Pregnancy and Breastfeeding
The safety of Cineset during pregnancy is not explicitly established. It is essential to consult with a healthcare provider to weigh potential risks and benefits. The FDA uses the Pregnancy and Lactation Labeling Rule to classify medication safety during pregnancy.
Similarly, the safety of taking Cineset while breastfeeding is unclear. Some medications can pass into breast milk and affect the nursing infant. Always consult your healthcare provider before taking any medication while breastfeeding to ensure the safety of both mother and child.
Table: Cineset Film Tablet 60 Mg Key Information
| Aspect | Details |
|---|---|
| Dosage | Start with 30 mg, may increase to 60 mg based on response |
| Administration | With food or shortly after a meal, swallow whole with water |
| Common Side Effects | Blurred vision, chest pain, dizziness, headache, nervousness, irregular heartbeat |
| Less Common Side Effects | Convulsions, cough, fever, loss of bladder control, lower back pain, muscle spasms, painful urination |
| Other Side Effects | Diarrhea, weakness, loss of appetite, nausea, vomiting, weight loss |
| Drug Interactions | Adjust dose if using strong CYP3A4 inhibitors like clarithromycin, itraconazole, or ritonavir |
| Food Interactions | Take with food or shortly after a meal |
| Driving Safety | Monitor for dizziness or blurred vision, avoid driving if affected |
| Contraindications | Do not use if serum calcium is below normal range |
| Pregnancy/Breastfeeding | Consult a healthcare provider for risks and benefits |
Conclusion
Cineset Film Tablet 60 Mg is an effective medication for managing conditions related to the parathyroid glands, particularly in cases of secondary hyperparathyroidism, hypercalcemia due to parathyroid cancer, and primary hyperparathyroidism when surgery is not an option. Proper administration, awareness of potential side effects, and understanding drug interactions are crucial for its safe and effective use. Always follow the specific directions provided by healthcare providers and consult them for any concerns regarding side effects, drug interactions, or use during pregnancy and breastfeeding.
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