The recent green light from the European Medicines Agency (EMA) for Tirzepatid’s expanded use marks a significant milestone in the field of weight management. Let’s dive into what this means for individuals, especially those dealing with Type 2 diabetes.
Tirzepatid’s Expanded Approval
The EMA has given its nod for Tirzepatid, a renowned incretin mimetic from Lilly Pharma, extending its approval beyond Type 2 diabetes to include weight loss. Marketed as Mounjaro®, this injectable solution, initially at 2.5 mg, is set to hit the shelves on November 20.
Weight Control Beyond Diabetes
EMA’s recommendation goes further, suggesting Tirzepatid as a supplement to a calorie-reduced diet and increased physical activity for weight control. This includes weight loss and maintenance for obese adults with a BMI of at least 30 kg/m2. Notably, those with a BMI between 27 and 30 kg/m2, coupled with weight-related comorbidities, could also benefit.
Potential Competition in the Market
If the EU Commission agrees, Tirzepatid is poised to challenge existing players like Novo Nordisk’s Semaglutide-containing drugs, Ozempic® and Wegovy®, in the competitive diabetes and weight loss medication market.
Insights from Surmount Studies
The SURMOUNT-Studienprogramm has highlighted Tirzepatid’s efficacy in achieving a significant reduction in body weight. Moreover, the SURPASS-Studien showcased its positive impact on glycemic control among individuals with Type 2 diabetes.
Understanding Tirzepatid’s Unique Mechanism
Tirzepatid stands out from other GLP-1 agonists like Semaglutid, Liraglutid, and Dulaglutid. It not only acts as an agonist for the GLP-1 hormone receptor but also for the GIP hormone receptor, earning it the label of a dual agonist, commonly known as Twincretin.
Beyond Twincretin: Exploring Triple-Agonists
The pursuit of effective medications continues with substances like Retatrutid, a triple agonist at the GLP-1, GIP, and glucagon receptors. Preliminary results indicate promising effects on blood sugar and body weight, hinting at a future direction for diabetes and weight management.
In conclusion, Tirzepatid’s potential expansion into weight management signifies a turning point. Keep an eye on developments as this medication could reshape the landscape of treatment options for individuals dealing with both Type 2 diabetes and obesity.
Original source: This information was Initially covered by PZ.de and has been translated for our readers.