Description
Tenoviral Film Tablet, containing the potent antiretroviral agent tenofovir disoproxil fumarate, is widely recognized for its critical role in the therapeutic management of HIV-1 infection and chronic hepatitis B virus (HBV) infection. As a nucleotide analogue reverse transcriptase inhibitor (NtRTI), it has earned its place as a key component in combination antiretroviral therapy (cART) due to its proven efficacy, safety profile, and enduring impact on patient outcomes.
It provides a dual benefit by significantly reducing viral replication and slowing disease progression, while simultaneously supporting immune restoration in affected individuals.
Brand Name
Tenoviral Film Tablet is the registered trade name for this pharmaceutical formulation.
Tenofovir disoproxil exerts its therapeutic effects by inhibiting the enzymes crucial for viral replication in both HIV-1 and hepatitis B infections. Through the blockade of reverse transcriptase, it impedes the elongation of viral DNA chains, thereby leading to a reduction in viral load.
Approved Indications and Clinical Applications
Tenoviral Film Tablet is approved for two primary therapeutic indications:
- Treatment of HIV-1 Infection: In adults and pediatric patients aged 2 years and older, Tenoviral is prescribed as part of a comprehensive antiretroviral regimen. It contributes to sustained virologic suppression, enhances CD4+ T-cell counts, and delays progression to AIDS. By maintaining long-term viral suppression, it also reduces the risk of HIV-related complications and improves quality of life.
- Management of Chronic Hepatitis B: The drug is utilized in adults and pediatric patients aged 12 years and older who have evidence of active viral replication and compensated liver disease. Tenofovir suppresses HBV DNA levels, minimizes hepatic inflammation, and reduces the progression of liver fibrosis and cirrhosis, thereby decreasing the risk of hepatocellular carcinoma.
Dosage and Administration Guidelines
The dosing regimen for Tenoviral Film Tablet depends on the patient’s age, weight, renal function, and the condition being treated:
- Adults with normal renal function typically receive a once-daily dose of 300 mg.
- Pediatric patients receive weight-based dosing, tailored to achieve optimal plasma concentrations while minimizing toxicity.
Tablets can be taken with or without food. Adherence to the prescribed treatment plan is essential for maximizing therapeutic effectiveness and preventing the emergence of drug resistance. In patients with renal impairment, dose adjustments or extended dosing intervals may be necessary based on creatinine clearance.
Use in Pediatric and Special Populations
Tenoviral Film Tablet has been rigorously studied in pediatric populations, with demonstrated efficacy in children aged 2 years and older for HIV and from age 12 for HBV. However, in infants and toddlers under 2 years, data on safety and efficacy remain limited.
In pregnant individuals, tenofovir is considered relatively safe (FDA Pregnancy Category B), but medical oversight is critical to balance maternal health with fetal safety. Breastfeeding considerations should involve risk-benefit assessments, as tenofovir can be excreted into breast milk.
Drug Interactions and Monitoring Protocols
Tenofovir disoproxil fumarate has a moderate interaction profile, necessitating careful consideration when prescribed with other medications. Clinicians must exercise caution when co-administering with drugs that affect renal function, such as aminoglycosides, nonsteroidal anti-inflammatory drugs (NSAIDs), or certain chemotherapeutic agents. Interactions with didanosine may lead to increased toxicity, including pancreatitis and neuropathy.
Similarly, co-administration with atazanavir without ritonavir may result in subtherapeutic drug levels. Regular monitoring of renal function (e.g., serum creatinine, estimated glomerular filtration rate) and bone mineral density is recommended for patients on long-term therapy.
Safety and Precautions
Tenoviral Film Tablet is generally well tolerated, but as with all medications, it carries a risk of side effects. Commonly reported adverse effects include:
- Gastrointestinal symptoms (nausea, diarrhea, abdominal pain)
- Headache
- Fatigue
Less frequent but more serious complications may include:
- Renal toxicity, including acute renal failure and Fanconi syndrome
- Bone demineralization, leading to osteopenia or osteoporosis
- Lactic acidosis and hepatomegaly, although rare, particularly in patients with underlying liver disease or prolonged therapy
Healthcare providers are encouraged to perform routine laboratory assessments and clinical evaluations to detect these conditions early and intervene appropriately.
Mechanism of Action
Once administered orally, tenofovir disoproxil fumarate is rapidly absorbed and converted into its active form, tenofovir diphosphate, within human cells. This pharmacologically active compound competes with deoxyadenosine 5′-triphosphate for incorporation into viral DNA by the enzyme reverse transcriptase. Upon incorporation, it causes premature termination of the DNA chain, thereby halting the synthesis of viral DNA.
This mechanism effectively inhibits viral replication in both HIV-1 and HBV infections. Through this action, Tenoviral Film Tablet significantly decreases viral load and reduces the risk of viral transmission, improving long-term clinical outcomes in patients.
Proper Storage Conditions
To maintain the medication’s potency and safety, Tenoviral Film Tablets should be stored at a temperature not exceeding 25°C (77°F) in a tightly closed container, away from moisture and direct sunlight. Patients should be advised not to use tablets that are expired or show signs of deterioration. Unused or expired medication should be discarded according to local regulations to prevent accidental ingestion or environmental contamination.
Conclusion
In conclusion, Tenoviral Film Tablet represents a cornerstone in the therapeutic armamentarium for the management of both HIV-1 infection and chronic hepatitis B. Adhering to the recommendations of healthcare providers is paramount to ensuring the safe and effective use of this medication. Should any concerns arise regarding its administration or potential adverse effects, patients are encouraged to seek guidance from their healthcare professionals promptly.
Summary of Tenoviral Film Tablet
| Attribute | Description |
|---|---|
| Composition | Tenofovir disoproxil fumarate |
| Drug Class | Nucleotide analogue reverse transcriptase inhibitor |
| Indications | HIV-1 infection, Chronic hepatitis B |
| Manufacturer | Gilead Sciences |
| Trade Name | Viread |
| Primary Uses | Management of HIV-1 infection and Chronic hepatitis B |
| Dosage | Variable, depending on specific condition |
| Pediatric Safety | Established in patients aged 2 years and older |
| Pregnancy and Breastfeeding | Consult healthcare provider |
| Common Side Effects | Gastrointestinal disturbances, fatigue, headache |
| Mechanism of Action | Inhibition of reverse transcriptase, viral DNA chain elongation |
| Storage Instructions | Follow packaging instructions |
This comprehensive guide aims to provide a detailed understanding of Tenoviral Film Tablet, enabling informed decision-making regarding its therapeutic use.
Zlatko Stefanov –
Hi we want to ask what is the price of Tenofovir Disoproxil 245mg and do you have them Thank you
Medical Guidance Center –
Hello Zlatko, this is Wikikenko,
Thank you for your inquiry about Tenofovir Disoproxil 245mg. As an online encyclopedia, WikiKenko does not sell medications. However, I’d be happy to assist you further. Please fill out our “Urgent Quotation” form providing your location and any prescription details. Our team will then work to source current pricing information for Tenofovir Disoproxil 245mg from verified suppliers in your area. We’ll also check availability and delivery timelines. Your health is our priority, so please only use this form for urgent medical needs as intended. I’m here if you have any other questions – let’s work together to help you access the required treatment.