Real-Life Data on Bivalent HPV Vaccination

FAQ Print
Real-Life Data on Bivalent HPV Vaccination

Real-Life Data on Bivalent HPV Vaccination


In a recent report in “Cell Host & Microbe,” data from Finland sheds light on the real-world implications of vaccinating girls and boys against human papillomaviruses (HPV). The study, led by Dr. Ville N. Pimenoff from the Karolinska Institut in Stockholm, explores the dynamics of HPV variants in 33 Finnish cities over time, considering scenarios where both genders, only girls, or no one was vaccinated.

Herding Immunity Dynamics

The study observed that communities where both girls and boys were vaccinated exhibited the strongest herd immunity. However, an interesting counterpoint emerged – there was an increased spread of HPV variants not covered by the vaccine.

Vaccine Specifics

The vaccine used in the study targeted HPV variants 16 and 18, responsible for about 70% of HPV-related cervical cancer cases, with additional cross-protection against variants 31 and 45, both considered carcinogenic.

Time-Frame and Population

Covering individuals born between 1992 and 1994, the study followed up with them at ages 18 (n = 11,396) and 22 (n = 5602), four and eight years post-HPV vaccination, respectively. The researchers assessed the presence of a total of 16 HPV variants.

Impact on Prevalence

Eight years post-vaccination, the prevalence of HPV variants 16 and 18 significantly decreased in cities where vaccination occurred. Notably, in cities where only girls were vaccinated, there was also a decrease in the prevalence of HPV variant 31. In cities with gender-inclusive vaccination, there was an additional marked decline in HPV variant 45.

Insights on Herd Immunity

Dr. Pimenoff commented that the results highlight the importance of achieving stronger herd immunity by vaccinating both boys and girls.

Type Replacement Phenomenon

The study also observed a phenomenon known as “Type Replacement,” where eliminated virus types were replaced by other HPV variants with lower oncogenicity. This occurrence was more pronounced in gender-inclusive vaccination scenarios compared to situations where only girls were vaccinated.

Expert Perspectives on Type Replacement

Dr. Tim Waterboer from the German Cancer Research Center notes two significant findings. Firstly, Type Replacement was more pronounced in gender-inclusive vaccination, emphasizing the necessity of vaccination across the entire population. Secondly, the speed of Type Replacement after eight years was unexpected.

Implications and Future Considerations

While the impact of Type Replacement on cancer risk remains uncertain, the general trend leans towards fewer cancer cases with vaccination. The replacement of virus variants may not necessarily lead to an increased cancer risk but could potentially contribute to a softening of the downward trend.

Relevance for Germany

Experts in Germany, including Professor Dr. Ulrike Wieland from the University Hospital Cologne, downplay the significance of HPV genotypes prevailing against which there was no vaccination. Given Germany’s predominant use of the nonavalent vaccine since 2016/2017, which covers some of the relevant genotypes, the impact on cancer risk is considered minimal.

Conclusion: Optimal HPV Vaccination Strategy

Professor Elmar A. Joura from the Medical University of Vienna concludes that the study’s observations, such as a minor increase in certain strains in vaccinated cohorts, reinforce the effectiveness of Germany’s, Austria’s, and Switzerland’s approach to HPV vaccination: gender-neutral and providing broader protection.


Original source: This information was Initially covered by pharmazeutische-zeitung.de and has been translated for our readers.


5 1 vote
Article Rating
Subscribe
Notify of
guest
0 Comments
Inline Feedbacks
View all comments


You might also like

  • How to Safely and Effectively Eliminate Those Pesky Age-Related Warts

    How to Safely and Effectively Eliminate Those Pesky Age-Related Warts

  • The Human as a Virus Carrier to Animals

    The Human as a Virus Carrier to Animals

  • Want to Lose Weight with Jogging Avoid These 4 Things

    Want to Lose Weight with Jogging? Avoid These 4 Things

More results…

Generic selectors
Exact matches only
Search in title
Search in content
Post Type Selectors

The expert search feature is especially useful for healthcare professionals, researchers, and scientists who require accurate and up-to-date information on pharmaceutical products. By narrowing down their searches using filters, they can easily access the relevant data they need, making informed decisions about treatment options or drug research endeavors.

Expert Search  →


Recent comments