Zemplar Injection Solution 5 Mcg

Zemplar Injection is a vital treatment option for patients with chronic kidney disease (CKD) who develop secondary hyperparathyroidism, a condition characterized by excessive parathyroid hormone (PTH) production. This comprehensive guide delves into the intricacies of Zemplar, exploring its formulation, mechanism of action, dosage recommendations, and potential side effects.

Dosage form

Pack size


5 Mcg



Generic Name (Ingredient)

4 Mcg Paricalcitol

Assuming your emergency circumstances for this product, visit Urgent Quotation page. Besides, for any pharmaceutical questions, please ask us in the comments section.


Zemplar injection is a clear, colorless, and particle-free aqueous solution containing the active ingredient paricalcitol, a synthetic vitamin D analog. Each milliliter of the solution contains 5 micrograms of paricalcitol, along with excipients such as ethanol (20% v/v) and propylene glycol (30% v/v).

How Does Zemplar Injection Work?

Paricalcitol, the active ingredient in Zemplar, is a selective vitamin D receptor (VDR) activator. It works by inhibiting parathyroid proliferation, effectively reducing elevated parathyroid hormone (PTH) levels associated with secondary hyperparathyroidism. Unlike traditional vitamin D therapies, paricalcitol has a minimal impact on calcium and phosphorus levels, making it a safer alternative for patients with chronic kidney disease.

Additionally, paricalcitol directly affects bone cells, helping to maintain bone volume and improve mineralization surfaces, which is crucial for patients with chronic kidney disease who often experience bone disorders.

Dosage and Administration

The dosage of Zemplar injection is determined by the patient’s age, condition, and response to treatment. Here are the general guidelines:

Adult Dosage:

  • Initiate at 0.04 mcg/kg to 0.1 mcg/kg (2.8 mcg to 7 mcg) no more frequently than every other day.
  • Adjust the dose to achieve the desired therapeutic range of intact PTH levels and maintain serum calcium within normal limits.
  • Monitor serum calcium levels twice weekly and intact PTH levels every 2 to 4 weeks.

Pediatric Dosage:

  • Initiate based on baseline intact PTH levels:
    • If < 500 pg/mL, start with 0.04 mcg/kg.
    • If ≥ 500 pg/mL, start with 0.08 mcg/kg.
  • Monitor serum calcium and intact PTH levels similarly to adults.

Zemplar is administered intravenously through a hemodialysis vascular access at any time during dialysis.

Available Forms

Zemplar injection is available in the following forms:

  • Single-dose vials:
    • 2 mcg/mL
    • 5 mcg/mL
  • Multiple-dose vial: 10 mcg/2 mL (5 mcg/mL)


Zemplar should not be used in patients with:

  • Hypercalcemia (high blood calcium levels)
  • Vitamin D toxicity
Key Information Details
Side Effects Common side effects may include nausea, vomiting, swelling in hands or feet, dizziness, joint pain, and runny nose. Seek medical attention for severe symptoms or suspected overdose.
Dosage Adult: 0.04-0.1 mcg/kg every other day<br>Pediatric: Based on PTH levels (0.04-0.08 mcg/kg)
Administration Intravenous through hemodialysis access during dialysis
Available Forms Single-dose vials (2 mcg/mL, 5 mcg/mL)<br>Multiple-dose vial (10 mcg/2 mL)
Contraindications Hypercalcemia, vitamin D toxicity
Drug Interactions Major: Allopurinol, amlodipine, aspirin, atorvastatin, carvedilol, and more<br>Moderate: Cholecalciferol, furosemide, lisinopril, omeprazole, prednisone, sevelamer, and more

Marketing Authorization

Zemplar injection is manufactured by AbbVie Ltd., headquartered in Maidenhead, UK, and has received marketing authorization in various countries, including Austria, Brazil, Ecuador, Estonia, Spain, Hong Kong, Ireland, Israel, Italy, Lithuania, Mexico, Romania, Singapore, Turkey, the United Kingdom, the United States, and South Africa.


Zemplar (paricalcitol) injection is a valuable treatment option for patients with chronic kidney disease undergoing dialysis, helping to manage secondary hyperparathyroidism and promote bone health. By selectively activating vitamin D receptors and reducing parathyroid hormone levels, Zemplar offers an effective solution with minimal impact on calcium and phosphorus levels.

However, it is crucial to follow your healthcare provider’s instructions, monitor your response to treatment, and report any adverse effects promptly.


There are no reviews yet.

Be the first to review “Zemplar Injection Solution 5 Mcg”

Your email address will not be published. Required fields are marked *

Use the form below to report an error

Please answer the questions as thoroughly and accurately as possible. Your answers will help us better understand what kind of mistakes happen, why and where they happen, and in the end the purpose is to build a better archive to guide researchers and professionals around the world.

If an image of the drug is not available on the Wikikenko health encyclopedia, you have the option to submit images/leaflets of the product. Following verification by our pharmaceutical specialist, your submitted images/leaflets will be included in our archive, with due acknowledgment of your contribution. Your cooperation in this matter would greatly assist researchers in finding the information they seek. Upload Images/Leaflet (Less than 2MB)

No Choosen File
(Max 2 MB)

The information on this page is not intended to be a substitute for professional medical advice, diagnosis, or treatment. always seek the advice for your physician or another qualified health provider with any questions you may have regarding a medical condition. Always remember to

  1. Ask your own doctor for medical advice.
  2. Names, brands, and dosage may differ between countries.
  3. When not feeling well, or experiencing side effects always contact your own doctor.


The truth is that when we’re sick, or worried about getting sick, the internet won’t help.

According to Wikipedia, cyberchondria is a mental disorder consisting in the desire to independently make a diagnosis based on the symptoms of diseases described on Internet sites.

Why you can't look for symptoms on the Internet

If diagnoses could be made simply from a textbook or an article on a website, we would all be doctors and treat ourselves. Nothing can replace the experience and knowledge of specially trained people. As in any field, in medicine there are unscrupulous specialists, differences of opinion, inaccurate diagnoses and incorrect test results.


People also search for…

More results…

Generic selectors
Exact matches only
Search in title
Search in content
Post Type Selectors

The expert search feature is especially useful for healthcare professionals, researchers, and scientists who require accurate and up-to-date information on pharmaceutical products. By narrowing down their searches using filters, they can easily access the relevant data they need, making informed decisions about treatment options or drug research endeavors.

Expert Search  →

Recent comments