Name: Zemplar Capsule: Uses, Dosage, Side Effects, FAQ | WikiKenko
Brand: (Catalent - A.B.D.)
SKU: 995218
Price: 22.07 EUR
Availability: InStock

Description

Table of Contents

1 Indications and Usage

2 Dosage and Administration

2.1 Initial Dosage

2.1.1 CKD Stages 3 and 4 in Adults:

2.1.2 Pediatric Patients (Ages 10 to 16 years):

2.2 Dose Titration (CKD Stages 3 and 4)

2.3 CKD Stage 5 in Adults

2.4 Pediatric Patients (Ages 10 to 16 Years) with CKD Stages 3 and 4

3 Safety Considerations

4 Zemplar (Paricalcitol) Interactions

5 Storage of Zemplar Capsules

6 Conclusion

Indications and Usage

Zemplar Capsule (Paricalcitol) is indicated for adults and pediatric patients (10 years and older) in the following scenarios:

Chronic Kidney Disease (CKD) Stages 3 and 4: To manage secondary hyperparathyroidism associated with CKD.
CKD Stage 5: For patients on hemodialysis or peritoneal dialysis.

Dosage and Administration

Initial Dosage

CKD Stages 3 and 4 in Adults:

Baseline intact parathyroid hormone (iPTH) ≤ 500 pg/mL: 1 mcg orally daily or 2 mcg three times a week.
Baseline iPTH > 500 pg/mL: 2 mcg orally daily or 4 mcg three times a week.

Pediatric Patients (Ages 10 to 16 years):

1 mcg orally three times a week.

Dose Titration (CKD Stages 3 and 4)

Adjust based on iPTH levels relative to baseline. Increase or decrease by 1 mcg daily or 2 mcg three times a week.

CKD Stage 5 in Adults

Initial Dose: Administer Zemplar capsules orally three times a week, no more frequently than every other day. Calculate the dose based on the formula: Dose (micrograms) = baseline iPTH (pg/mL) divided by 80.
Dose Titration: Individualize the dose based on iPTH, serum calcium, and phosphorus levels. Titrate Zemplar dose based on the formula: Dose (micrograms) = most recent iPTH level (pg/mL) divided by 80.

Pediatric Patients (Ages 10 to 16 Years) with CKD Stages 3 and 4

Initial Dose: Administer Zemplar 1 mcg capsule orally three times a week, no more frequently than every other day.
Dose Titration: Individualize and titrate Zemplar dose based on iPTH, serum calcium, and phosphorus levels to maintain an iPTH level within the target range. Increase the administered dose every 4 weeks in 1 mcg increments while maintaining the three times per week regimen.

Safety Considerations

Parameter	Details
Monitoring	– Regular blood tests for iPTH, calcium, and phosphorus. – Adherence to prescribed medication plan and dietary restrictions.
Common Side Effects	– Diarrhea – Nasal/throat inflammation – Dizziness – Vomiting – High blood pressure – Allergic reactions – Nausea – Swelling
Important Safety Facts	– Hypercalcemia Warning: High calcium levels can lead to serious health issues. – Medication Interactions: Inform your doctor about all medications you’re taking. – Patient Counseling: Discuss any signs of high calcium with your healthcare provider.

Zemplar (Paricalcitol) Interactions

Zemplar (Paricalcitol) may interact with certain medications, such as:

Apalutamide: Can decrease the level or effect of Paricalcitol.
Conivaptan: Can increase the level or effect of Paricalcitol.

Always inform your healthcare provider about all medications you’re taking to ensure optimal treatment outcomes.

Storage of Zemplar Capsules

Zemplar capsules should be stored at 25°C (77°F), with excursions permitted between 15°C to 30°C (59°F to 86°F).

Conclusion

In conclusion, Zemplar Capsule 2 Mcg (Paricalcitol) is a crucial medication for managing secondary hyperparathyroidism associated with chronic kidney disease. By understanding the indications, dosage, safety considerations, and potential interactions, healthcare professionals and patients can ensure the safe and effective use of this essential drug for optimal kidney health.

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