Xenetix 300 Injection Solution

Xenetix 300 is a diagnostic agent primarily used in radiological examinations. This contrast agent enhances the visualization of specific body parts, making it easier to outline and diagnose various medical conditions. It is exclusively used for diagnostic purposes and administered under strict medical supervision.

Dosage form

Pack size

Potency

658.1 Mgi/Ml 1X50Ml

Manufacturer

Origin

Generic Name (Ingredient)

65, 810 G Per 100Ml Iobitridol (Corresponding Iodine Amount 30.00 G)

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Description

Composition

Xenetix 300 contains the active ingredient Iobitridol. Each milliliter of Xenetix 300 solution comprises 658.1 mg of Iobitridol, equivalent to 300 mg of iodine per milliliter. The solution also includes auxiliary substances such as sodium, calcium edetate, trometamol, trometamol hydrochloride, sodium hydroxide or hydrochloric acid (as pH balancers), and water for injection.

Usage

Xenetix 300 is utilized to improve the contrast of images obtained during radiological examinations. This enhancement allows for better visualization and delineation of body parts, facilitating accurate diagnoses. It is particularly useful in computed tomography (CT) scans and catheterization laboratory (Cath Lab) procedures.

Administration of Xenetix 300

Xenetix 300 is administered by injection, and the method can vary depending on the type of examination.

Intravascular Route

In many cases, Xenetix 300 is injected into a blood vessel. During the procedure, patients are closely monitored by a doctor. A plastic needle is left in the vein to allow for the injection of emergency medications if necessary.

Intra-articular or Intra-uterine Route

In some instances, Xenetix 300 is injected into a body cavity, such as within a joint (intra-articular) or the uterus (intra-uterine).

Dosage

The dosage of Xenetix 300 depends on the type of examination, the patient’s weight, and kidney function. As with all contrast media, the lowest dose necessary to achieve adequate visualization should be used.

Onset of Action

Xenetix 300 typically starts working within one hour after administration. However, the effects can sometimes be observed up to seven days later. The half-life of Xenetix 300 in humans is approximately 1.8 hours, with a mean systemic clearance of 93 mL/min.

Side Effects

Common side effects of Xenetix 300 include:

  • Allergic Reactions: Angioedema (rare), allergic shock reaction (very rare)
  • Respiratory Symptoms: Rhinitis, shortness of breath, cough, difficulty swallowing, apnea, bronchospasm, laryngeal edema
  • Other Symptoms: Fatigue, headache, low blood pressure, fast or slow heart rate, cardiac arrest, stomachache, nausea

Storage

Xenetix 300 should be stored out of reach and sight of children, in its original packaging, and not used after the expiry date. Although specific storage conditions are not provided, it is generally advisable to store medicines below 30°C and protect them from light.

Precautions

General Precautions

All iodine-containing contrast media carry a risk of allergic reactions. These reactions can range from mild to life-threatening.

Specific Precautions

Xenetix 300 should not be used if:

  • You are allergic to Iobitridol or any other ingredients in Xenetix.
  • You have previously had an allergic reaction to Iobitridol.
  • You have excess thyroid hormones.
  • You are pregnant or think you might be pregnant and are scheduled for a hysterosalpingography.
  • You have had a severe skin reaction to Xenetix.

Additional Precautions

Inform your doctor if you:

  • Have had an allergic reaction to a contrast agent previously.
  • Are asthmatic and have had an asthma attack within the last eight days.
  • Have a history of allergic reactions.
  • Have sickle cell disease.
  • Have conditions causing water or electrolyte imbalance.

Interactions

With Food and Drinks

There are no known interactions between Xenetix 300 and food or drinks. However, it is advisable to follow your doctor’s or pharmacist’s instructions regarding eating or drinking before the examination. Inform your doctor if you regularly consume large amounts of alcohol.

With Other Medicines

Inform your doctor or pharmacist if you are taking or have recently taken any other medicines. This is especially important if you have heart disorders, blood pressure issues, diabetes, or have recently received interleukin-2 (a cancer treatment).

Benefits

Xenetix 300 significantly enhances the contrast of images during radiological examinations, allowing for better visualization and delineation of body parts. This improved contrast aids in identifying abnormalities or conditions that may not be visible with standard imaging techniques.

Alternatives to Xenetix 300 for Contrast-Enhanced Imaging

Iopromide-300 and -370 (Ultravist)

Iopromide, also known as Ultravist, is an iodine-based contrast agent approved for contrast-enhanced mammography and various intra-arterial and intravenous procedures.

Other Contrast Agents

All current CT contrast agents are based on the triiodinated benzene ring, with the iodine atom providing radiopacity. These agents are designed to optimize properties like osmolality, tonicity, hydrophilicity, and viscosity.

Contrast Echocardiography

Contrast echocardiography enhances echocardiographic resolution and provides real-time assessment of intracardiac blood flow. Agitated saline contrast helps visualize the right heart and detect right-to-left shunts.

Summary Table

Aspect Details
Active Ingredient Iobitridol
Concentration 300 mg of iodine per mL
Usage Enhances contrast in radiological exams
Common Side Effects Allergic reactions, respiratory symptoms, fatigue, headache
Administration Routes Intravascular, intra-articular, intra-uterine
Dosage Depends on examination type, patient’s weight, kidney function
Onset of Action Within one hour, can be observed up to seven days
Storage Conditions Below 30°C, protect from light
Precautions Allergies, thyroid issues, pregnancy
Interactions Inform about all medications and regular alcohol consumption
Alternatives Ultravist, other iodine-based agents

Conclusi|on

Xenetix 300 is a vital diagnostic tool in radiological imaging, enhancing the contrast and visualization of body parts for accurate diagnosis. Proper administration and adherence to precautions are essential to ensure safety and effectiveness. Always consult healthcare professionals for personalized advice and information regarding the use of this contrast agent.

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The information on this page is not intended to be a substitute for professional medical advice, diagnosis, or treatment. always seek the advice for your physician or another qualified health provider with any questions you may have regarding a medical condition. Always remember to

  1. Ask your own doctor for medical advice.
  2. Names, brands, and dosage may differ between countries.
  3. When not feeling well, or experiencing side effects always contact your own doctor.

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