Vitpso Gel %0.1

(1 customer review)

Vitpso Gel 0.1% is a topical dermatological preparation playing a crucial role in the management of various chronic skin disorders, especially those responsive to photochemotherapy. This medicinal gel features 8-Methoxypsoralen (Methoxsalen) as its active compound, belonging to the psoralen drug class. Methoxsalen functions by increasing the skin’s sensitivity to ultraviolet A (UVA) light, thereby enabling targeted phototherapy for conditions like vitiligo and psoriasis.

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Dosage form

Pack size

Potency

%0.1 50G

Manufacturer

Origin

Generic Name (Ingredient)

Within 1 Gram Of Gel: 8-Methoxyporal (Metoxaline) 1 Mg

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Description

Vitpso Gel 0.1%, a topical dermatological preparation, plays a significant role in the management of various chronic skin disorders, particularly those that benefit from photochemotherapy. This medicinal gel contains the active compound 8-Methoxypsoralen (also known as Methoxsalen), a member of the psoralen class of drugs. Methoxsalen enhances the skin’s sensitivity to ultraviolet A (UVA) light, facilitating targeted phototherapy in diseases such as vitiligo and psoriasis.

Pharmacological Profile and Mechanism of Action

The core of Vitpso Gel 0.1% lies in its active ingredient, 8-Methoxypsoralen, at a concentration of 1 mg per gram of gel. Methoxsalen is a naturally occurring furocoumarin extracted from plants like Ammi majus and Heracleum candicans. As a photosensitizing agent, Methoxsalen binds with DNA upon activation by UVA light, leading to the formation of covalent bonds that inhibit DNA synthesis and cell proliferation. This mechanism underpins its effectiveness in conditions characterized by abnormal or excessive skin cell growth.

By delaying cellular replication and promoting immunomodulatory effects, Methoxsalen helps reduce the severity of psoriatic plaques, stimulate repigmentation in vitiligo, and control lesions in cutaneous T-cell lymphomas. The dual ability to affect cellular kinetics and immune responses makes this drug highly versatile within dermatological therapeutics.

Therapeutic Indications

Vitpso Gel 0.1% is employed in the treatment of several phototherapy-responsive dermatoses. The most common indications include:

  • Vitiligo: A condition marked by the loss of skin pigment. Methoxsalen helps reactivate melanocytes under UVA exposure.
  • Psoriasis: Particularly in chronic plaque forms, it aids in reducing epidermal hyperproliferation.
  • Mycosis fungoides (cutaneous T-cell lymphoma): Methoxsalen reduces lesion severity when used in PUVA (Psoralen + UVA) protocols.
  • Photodermatoses: Helps in desensitizing the skin to light-induced eruptions.
  • Generalized lichen planus and cutaneous mastocytosis: Used in specific cases under medical supervision.

Formulation and Physical Characteristics

Vitpso Gel is a transparent, homogeneous gel that emits a characteristic odor and appears slightly yellowish. Each unit is packaged in a 50 g plastic bottle, ensuring convenient dispensing and easy application to the skin.

The formulation includes several auxiliary substances that support the stability, texture, and efficacy of the gel. These excipients are:

  • Polyethylene glycol 400
  • Propylene glycol
  • Polyquaternium-10
  • Ethanol
  • Purified water

These ingredients contribute to the gel’s hydrating, antimicrobial, and penetration-enhancing properties, facilitating optimal delivery of the active compound.

Administration Guidelines

Vitpso Gel 0.1% must be applied topically to the affected skin areas under strict medical supervision. It is typically used in conjunction with controlled UVA light exposure, either from artificial UVA lamps or natural sunlight, as part of PUVA therapy. The gel should be evenly spread in a thin layer and allowed to absorb fully before UVA exposure.

To minimize systemic absorption and the risk of phototoxicity, the gel must be handled with care, ensuring it is used precisely as directed by a healthcare professional. Its use should be limited to the affected areas, and patients should avoid exposure to sunlight without proper timing and protection as advised by their physician.

Safety Considerations and Contraindications

Vitpso Gel 0.1% should not be self-administered. It requires the guidance of a qualified healthcare provider to determine suitable dosing, exposure schedules, and skin protection protocols. This is particularly important due to the photosensitizing nature of Methoxsalen, which, if misused, can lead to serious skin reactions or long-term damage.

Contraindications include:

  • Hypersensitivity to Methoxsalen or any excipients in the formulation
  • History of photosensitivity or lupus erythematosus
  • Melanoma or precancerous skin lesions
  • Severe liver disorders

Patients undergoing therapy must adhere to all safety precautions, including the use of UVA-blocking eyewear during and after exposure and avoiding prolonged sun exposure for 24 to 48 hours post-treatment.

Side Effects

While generally well-tolerated when used under medical guidance, Vitpso Gel may cause local or systemic side effects, especially when coupled with UVA exposure. Commonly observed reactions include:

  • Erythema (redness)
  • Dryness or burning sensation
  • Itching
  • Increased risk of sunburn

Less frequently, more serious reactions such as phototoxic blistering, hyperpigmentation, or long-term skin aging may occur. Very rarely, there may be a risk of photocarcinogenesis with prolonged or improperly managed PUVA therapy.

Special Populations

The use of Vitpso Gel 0.1% in children, pregnant women, and lactating mothers is not well-established. It should only be considered in these populations if the potential therapeutic benefits outweigh the risks, and only under strict medical supervision.

Summary Table: Vitpso Gel 0.1% Key Information

Category Details
Active Ingredient 8-Methoxypsoralen (Methoxsalen)
Formulation Topical gel, 0.1% concentration
Auxiliary Ingredients PEG 400, Propylene glycol, Polyquaternium-10, Ethanol, Purified water
Packaging 50 g plastic bottle
Indications Vitiligo, Psoriasis, Mycosis fungoides, Photodermatoses
Application Method Topical use with UVA exposure; under medical supervision only
Common Side Effects Redness, burning, dryness, itching
Serious Risks Phototoxic reactions, hyperpigmentation, long-term risk of skin aging/cancer
Contraindications Photosensitivity, melanoma, lupus, severe liver disease
Precautions Avoid sun exposure; use protective eyewear; not for self-use

Conclusion

Vitpso Gel 0.1% represents a targeted and highly effective therapeutic option for managing complex skin disorders that respond to photochemotherapy. Its active compound, Methoxsalen, harnesses the synergy of chemical and light therapy to achieve clinical improvements in otherwise resistant dermatologic conditions. While offering significant therapeutic benefits, its use must always be governed by stringent clinical protocols to ensure patient safety and efficacy. The informed and cautious application of Vitpso Gel 0.1%, in coordination with a qualified healthcare provider, remains essential for achieving optimal dermatological outcomes.

1 review for Vitpso Gel %0.1

  1. Shayma

    Good

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