Vastarel Film Tablet

Description

Active Ingredient

The active ingredient in Vastarel film tablet is Trimetazidine dihydrochloride. Each film-coated tablet contains 20 mg of this substance, which plays a crucial role in its therapeutic effects.

Mechanism of Action

Trimetazidine, the active component of Vastarel, is classified as an anti-ischemic (anti-anginal) metabolic agent. It enhances myocardial glucose utilization by inhibiting the activity of long-chain 3-ketoacyl CoA thiolase. This inhibition leads to a reduction in fatty acid oxidation and a corresponding increase in glucose oxidation. The result is better energy production in heart cells, particularly under conditions of hypoxia or ischemia, where oxygen supply is limited. By preserving intracellular ATP levels, Trimetazidine helps maintain cellular functions, making it beneficial for patients with angina pectoris.

Indications

Vastarel is indicated for use in adult patients to manage angina pectoris. It is typically used alongside other medications to provide comprehensive treatment for this condition.

Contraindications and Precautions

Vastarel is contraindicated in patients with allergies to Trimetazidine or any other ingredients in the tablet. It is also unsuitable for individuals with Parkinson’s disease or severe kidney issues. Special caution should be exercised when prescribing this medication to elderly patients and those with moderate renal impairment.

Side Effects

Vastarel film tablet, like all medications, can cause side effects. Commonly reported side effects include:

Side Effect	Description
Dizziness	May impair the ability to drive or operate machinery
Drowsiness	Can affect daily activities and safety
Movement Disorders	Symptoms include trembling, rigidity, slow movements, and unbalanced walking, particularly in elderly patients

Other side effects may occur, and it is important to consult a healthcare provider for advice if unusual symptoms develop.

Precautions During Use

Patients taking Vastarel should be aware of several precautions:

• Driving and Using Machines: Due to potential dizziness and drowsiness, caution is advised when driving or operating machinery.
• Drug Interactions: Always inform your doctor about any other medications you are taking, including over-the-counter drugs.
• Pregnancy and Breastfeeding: It is generally recommended to avoid Vastarel during pregnancy and breastfeeding. Consult your healthcare provider for personalized advice.
• Allergies and Health Conditions: Do not take Vastarel if allergic to Trimetazidine or any other components, and avoid it if you have Parkinson’s disease or severe kidney problems.
• Elderly Patients and Those with Kidney Disease: Dose adjustments may be necessary for these populations.

Vastarel Dosing Regimen

Vastarel is available in two dosages: 20 mg and 35 mg.

Dosage	Recommended Use
Vastarel 20 mg	One tablet three times a day during meals
Vastarel 35 mg	One tablet twice a day during meals

Special considerations include dose adjustments for patients with kidney disease and elderly patients over 75 years old. Always follow the healthcare provider’s instructions for dosage and frequency.

Storage Requirements

Specific storage instructions for Vastarel film tablet are not readily available. However, general guidelines for medication storage include keeping it in a cool, dry place away from direct sunlight and out of reach of children. Avoid storing medications in bathrooms or near sinks due to humidity.

For precise storage information, refer to the medication packaging or consult a pharmacist.

Mechanism of Action

The mechanism of action of Trimetazidine involves enhancing the heart muscle’s energy metabolism by shifting the energy production from fatty acid oxidation to glucose oxidation. This shift helps maintain intracellular ATP levels, crucial for the proper functioning of ionic pumps and maintaining cellular homeostasis. This mechanism is particularly beneficial during episodes of angina, where oxygen supply to the heart muscle is reduced.

Clinical Uses of Vastarel

Vastarel Film Tablet, containing Trimetazidine, is used for several clinical purposes:

Clinical Use	Description
Angina Pectoris	Protects heart cells from reduced oxygen supply during angina episodes
Heart Failure	Helps in managing heart failure, a condition where the heart pumps inadequately
Peripheral Artery Disease	Used in treating PAD, where blood vessels narrow and restrict blood flow

Vastarel is intended for use in adult patients and is often prescribed in combination with other medications. Consult with a healthcare professional for more information.

Drug Interactions

There are no widely reported drug interactions with Vastarel. However, it is essential to consult a healthcare provider before starting any new medication, including over-the-counter drugs and supplements, to ensure safety and avoid potential interactions.

Conclusion

Vastarel film tablet is a valuable medication for the treatment of angina pectoris and other cardiovascular conditions. Understanding its mechanism of action, proper usage, potential side effects, and precautions is essential for safe and effective therapy. Always consult healthcare professionals for detailed and personalized medical advice.

Category	Details
Active Ingredient	Trimetazidine dihydrochloride (20 mg per tablet)
Mechanism of Action	Enhances myocardial glucose utilization, maintains ATP levels
Indications	Angina pectoris, heart failure, peripheral artery disease
Side Effects	Dizziness, drowsiness, movement disorders
Precautions	Avoid in Parkinson’s disease, severe kidney issues
Dosage	20 mg: One tablet thrice daily; 35 mg: One tablet twice daily
Storage	Cool, dry place away from sunlight and moisture

This overview provides a comprehensive understanding of Vastarel film tablet, ensuring informed decisions and optimal patient care.