Description
Composition
In addition to urea, Urederm Hydro Emulsion comprises several auxiliary substances including:
- Dimethicone
- Octyldodecanol
- Cetearyl alcohol
- Poloxamer
- Steareth-2
- Steareth-20
- Glycerin
- Butylhydroxytoluene (E321)
- Disodium EDTA
- Polyacrylamide/C13-14 isoparaffin/laureth-7 (Sepigel 305)
- Polyhexanide
- Purified water
Indications
Urederm Hydro Emulsion is primarily used to treat skin diseases associated with chronic dryness such as:
- Ichthyosis (characterized by dry, scaly skin)
- Xeroderma (dry skin)
- Atopic eczema (hypersensitivity-induced eczema with reddish lesions)
- Asteatotic eczema (dry skin eczema due to aging, dry air, excessive water contact, detergents, and improper nutrition)
Additionally, it can be used intermittently with topical corticosteroids for enhanced treatment effects.
Mechanism of Action
Urea, the active ingredient, is naturally found in the skin’s outer layer, the stratum corneum. It functions to moisturize the skin by retaining water within the stratum corneum through the skin’s natural oils. This process slows down water evaporation from the skin, reduces irritation, maintains skin elasticity, and improves overall appearance.
Contraindications
Urederm Hydro Emulsion should not be used in the following cases:
- Allergy or hypersensitivity to urea or any component of the emulsion
- Presence of wounds or open sores
- Use on infants (due to lack of systematic investigation for skin irritation)
- Application on large surface areas in patients with severe kidney failure
Side Effects
Common Side Effects
The most common side effects include:
- Burning
- Itching
- Stinging
- Redness
- Irritation
These effects generally occur at the application site. If they persist or worsen, it is advisable to consult a healthcare professional.
Serious Side Effects
Though rare, some serious side effects include:
- Unusual changes in the skin (blistering, peeling)
- Signs of skin infection
Immediate medical attention is recommended if any of these serious side effects occur.
Hypersensitivity Reactions
Hypersensitivity reactions, such as erythema, skin burning, and pruritus, may occur. In such cases, discontinuation of the treatment is necessary.
Other Reported Side Effects
Although rare, fever and chills have been reported following the infusion of soya oil emulsion. Other rare reactions include dyspnea, cyanosis, hyperlipidemia, hypercoagulability, nausea, vomiting, headache, and chest and back pain.
Effects on Dental Health
Urederm may affect the enamel’s organic components, leading to increased susceptibility to erosion and decreased abrasion resistance.
Storage Instructions
General Storage Guidelines
Store Urederm Hydro Emulsion in a safe place out of reach of children, in its original packaging until use.
Temperature Conditions
Maintain storage at room temperature, avoiding extreme heat or cold which can degrade the medication.
Light and Moisture
Keep away from direct light and moisture. Do not store in a bathroom or near a sink. Heat and dampness can destroy the emulsion.
Expiry Date
Do not use the product after its expiry date or if the packaging is torn or tampered with. Dispose of it by returning it to a pharmacist if expired or damaged.
Disposal
Consult your pharmacist for proper disposal methods when the emulsion is no longer needed or has expired.
Urederm Hydro Emulsion Use During Pregnancy and Breastfeeding
Use During Pregnancy
Use during pregnancy should be limited to when it is clearly needed, and the risks and benefits should be discussed with a doctor.
Use During Breastfeeding
The effects during breastfeeding are not well-known, and it is unknown if the drug passes into breast milk. Consultation with a healthcare provider is essential before use.
Alternatives to Urederm Hydro Emulsion
Prescription Alternatives
- Clobetasol Propionate Cream: A stronger option for severe skin conditions like eczema, psoriasis, and dermatitis.
- Stelara (ustekinumab): An immunosuppressant for chronic inflammation.
- Tremfya (guselkumab): An interleukin inhibitor for plaque psoriasis or psoriatic arthritis.
Over-the-Counter Alternatives
- Hydrocortisone Cream: Reduces inflammation and itching, used for mild skin conditions.
- Calamine Lotion: Soothes skin conditions like poison ivy, sunburn, and chickenpox.
- Betamethasone Dipropionate Cream: Treats various skin conditions, including eczema and dermatitis.
Natural Alternatives
- Olive Oil: Acts as a natural moisturizer.
- Coconut Oil: Moisturizes and has anti-inflammatory properties.
- Honey: Emollient and humectant, locking in hydration.
- Tea Bags: Provide cooling and anti-inflammatory effects.
- Petroleum Jelly: Effective natural skin barrier.
- Avocado Mask: Offers antioxidants for the skin.
- Oatmeal Soak: Soothes skin conditions.
- Nourishing Oils: Act as natural skin barriers.
- Milk Compresses: Provide anti-inflammatory treatment.
- Fruit Enzyme Cleanser: Gentle exfoliation.
- Aloe Vera Gel: Soothes and hydrates the skin.
Benefits of Urederm Hydro Emulsion
- Hydrating Properties: Urea effectively moisturizes and locks in hydration, treating dry skin conditions.
- Keratolytic Effects: Breaks down keratin, aiding in the shedding of dead skin cells, smoothing the skin.
- Treatment of Skin Conditions: Effective for conditions with chronic dryness like ichthyosis, xeroderma, atopic eczema, and asteatotic eczema.
- Complementary Treatment: Can be used with topical corticosteroids for enhanced treatment.
- Gentle Exfoliation: Provides gentle exfoliation, improving skin’s appearance and health.
Usage and Duration for Results
The time to see results can vary depending on the individual and condition being treated. Regular use is essential for maximum benefit. Urea increases moisture in the skin and aids in the shedding of dead skin cells, leading to improvements over time. Consistency in application, as directed by a healthcare professional, is key to achieving the best results.
Summary Table
| Category | Details |
|---|---|
| Active Ingredient | Urea (100 mg per gram) |
| Common Side Effects | Burning, itching, stinging, redness, irritation |
| Serious Side Effects | Blistering, peeling, signs of infection |
| Hypersensitivity Reactions | Erythema, burning sensation, pruritus |
| Storage Instructions | Store at room temperature, avoid light and moisture, keep out of reach of children, do not use after expiry |
| Pregnancy/Breastfeeding | Use only when necessary during pregnancy, consult healthcare provider during breastfeeding |
| Benefits | Hydrating, keratolytic effects, treats chronic dry skin conditions, can be used with corticosteroids, gentle exfoliation |
| Alternatives | Clobetasol Propionate, Stelara, Tremfya, Hydrocortisone Cream, Calamine Lotion, Betamethasone Dipropionate, Olive Oil, Coconut Oil, Honey, etc. |
Urederm Hydro Emulsion is a versatile and effective treatment for various dry skin conditions. Its moisturizing and keratolytic properties, along with its ability to be used alongside other treatments, make it a valuable addition to skincare routines. However, always consult a healthcare professional for personalized advice and treatment plans.
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