Parisitol I.V. Injection Solution Iceren Ampul 5 Mcg/Ml
Parisitol I.V. Injection Solution Iceren Ampul 5 Mcg/Ml stands as a notable pharmaceutical offering, manufactured by Pharmada and originating from Turkey. This article delves into the composition, medical uses, dosage, mechanism of action, and comparison with Vitamin D2, offering insights into its therapeutic potential and clinical implications.
5 Mcg/Ml 5X1Ml
|Generic Name (Ingredient)
Each 1 Ml Ampoule; 5 Mcg Of Active Substance As An Active Substance.
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Please be informed that, although the available information may be limited, this page provides information regarding the ingredient Parikalsitol, which is used in the Parisitol I.V. Injection Solution Iceren Ampul 5 Mcg/Ml.
Parisitol I.V. Injection Ingredients
The active constituent of Parisitol I.V. Injection Solution Iceren Ampul 5 Mcg/Ml is parikalsitol, with each 1 ml ampoule containing 5 mcg of this vital substance. Parikalsitol, a synthetic form of vitamin D, serves as the cornerstone of this medication, exerting its therapeutic effects on secondary hyperparathyroidism associated with chronic kidney failure.
Parikalsitol, also known as Paricalcitol, emerges as a vital therapeutic agent in the prevention and treatment of secondary hyperparathyroidism linked with chronic kidney failure. As an analog of 1,25-dihydroxyergocalciferol, the active form of vitamin D, Parikalsitol plays a pivotal role in modulating parathyroid hormone secretion and maintaining calcium-phosphate homeostasis.
Like all medications, Parikalsitol may elicit certain adverse effects, including alterations in heart rate, flu-like symptoms, mucosal ulcers, respiratory distress, seizures, and hypercalcemia. Patients should exercise vigilance and promptly report any untoward reactions to their healthcare providers.
Recommended Dosage of Parikalsitol
The optimal dosage of Parikalsitol varies depending on the patient’s clinical profile and disease severity. Injectable dosages range from 0.04 to 0.1 mcg/kg, administered as a bolus dose during hemodialysis sessions. Oral dosages are contingent on the stage of chronic kidney disease, with precise recommendations tailored to individual patient needs.
Mechanism of Action
Parikalsitol exerts its therapeutic effects by binding to specific receptors on the parathyroid glands, thereby mitigating parathyroid hormone secretion. This mechanism helps regulate calcium and phosphate levels, thereby safeguarding against renal osteodystrophy and preserving bone health in patients with chronic kidney failure.
Role in Chronic Kidney Disease
In chronic kidney disease, impaired vitamin D metabolism precipitates secondary hyperparathyroidism, predisposing individuals to bone demineralization and metabolic derangements. Parikalsitol supplementation offers a targeted therapeutic approach to mitigate these complications and optimize patient outcomes.
Comparison with Vitamin D2
Vitamin D2, or ergocalciferol, represents an alternative form of vitamin D sourced from plant and fungal sources. While both vitamin D2 and Parikalsitol share therapeutic indications for hypoparathyroidism and rickets, Parikalsitol exhibits superior efficacy in managing secondary hyperparathyroidism associated with chronic kidney disease.
Parisitol I.V. Injection Solution Iceren Ampul 5 Mcg/Ml emerges as a cornerstone in the management of secondary hyperparathyroidism complicating chronic kidney disease. With its potent therapeutic effects and well-established safety profile, Parikalsitol stands as a pivotal therapeutic agent in the armamentarium against renal osteodystrophy and metabolic bone disease. As with any medication, meticulous attention to dosage, monitoring, and adverse effects is imperative to ensure optimal patient outcomes and therapeutic efficacy.
|0.04 to 0.1 mcg/kg (injectable)
|Varies based on CKD stage (oral)
|Cardiac irregularities, fever, ulcers, etc.
|Mechanism of Action
|Parathyroid hormone modulation
|Superior efficacy in CKD vs. Vitamin D2
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