Pareglin Film Coated Tablet 2 Mg/500Mg

Pareglin, a medication amalgamating 2 mg of repaglinide and 500 mg of metformin hydrochloride, takes center stage as a powerful player in the realm of diabetes management. In this comprehensive guide, we’ll explore its mechanisms of action to dosages, precautions, potential side effects, and more.

Dosage form

Pack size


2 Mg/500Mg



Generic Name (Ingredient)

Each Film Contains 2 Mg Of Repaglinide And 500 Mg Of Metformin Hydrochloride.

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Repaglinide and Metformin Hydrochloride

At the heart of Pareglin lie two dynamic active ingredients:

  1. Repaglinide: This component kick-starts your pancreas to produce more insulin, effectively lowering your blood sugar levels. It’s a swift responder, making it particularly effective during mealtime.
  2. Metformin Hydrochloride: In contrast, metformin operates by reducing glucose production in the liver and curtailing glucose absorption in the intestines. It plays a pivotal role in maintaining stable blood sugar levels.

Type 2 Diabetes Management

Pareglin serves as a crucial tool in the management of type 2 diabetes. Specifically, it targets adults with type 2 diabetes mellitus who are either already undergoing treatment with a meglitinide and metformin HCl or are struggling with glycemic control using meglitinide or metformin HCl alone. This medication is not intended for individuals with type 1 diabetes or those facing diabetic ketoacidosis, as its efficacy in these situations is limited.

Pareglin Usage

For Pareglin to work its magic, it should be consumed orally at least 15 to 30 minutes before each meal. If a meal is skipped, the corresponding dose should also be omitted. Consistency is key, and adhering to a regular schedule maximizes the benefits.


The appropriate dosage of Pareglin is a product of individualization, considering the patient’s current treatment regimen, effectiveness, and tolerance levels. it can be administered 2 to 3 times daily, with a maximum daily dose of 10 mg Repaglinide/2500 mg Metformin HCl. However, caution should be exercised to avoid exceeding 4 mg Repaglinide/1000 mg Metformin HCl.


Before embracing Pareglin, take heed of the following precautions:

  • Allergies: Avoid Pareglin if you have allergies to repaglinide, metformin, or any other components of the medication.
  • Diabetes Type Matters: Pareglin is not recommended for type 1 diabetes patients or those experiencing diabetic ketoacidosis.
  • Liver and Kidney Health: Severe liver disease, liver failure, or Glomerular Filtration Rate (GFR) values below 30 mL/min/1.73 m² warrant careful consideration, as Pareglin might not be suitable in these cases.

Side Effects

Like any medication, Pareglin can introduce side effects. Should you experience unusual symptoms during its usage, prompt consultation with your healthcare provider or pharmacist is crucial.

Hypoglycemia: A Possible Side Effect

It’s important to note that hypoglycemia, or low blood sugar, is the most common side effect associated with Pareglin. Recognizing symptoms such as headache, hunger, weakness, sweating, tremors, irritability, trouble concentrating, rapid breathing, fast heartbeat, fainting, or seizure is imperative. Severe hypoglycemia can be life-threatening. Always carry hard candy or glucose tablets in case of low blood sugar episodes.

When Does Pareglin Begin Its Work?

Repaglinide, one of Pareglin’s constituents, typically springs into action within approximately 30 minutes post-consumption, making it highly effective during meals. In contrast, metformin may require a bit more patience, taking several days to a couple of weeks for noticeable effects on blood sugar levels. However, individual variations are expected, and your healthcare provider can provide tailored guidance.

Weight Management

Pareglin, containing repaglinide, has the potential to induce weight gain. Some diabetes medications, including repaglinide, enhance glucose absorption by cells, subsequently converting excess glucose into fat. This typically results in a weight gain ranging from 5 to 10 pounds.

However, individual responses may vary. If weight gain concerns you while using it, discussing this with your healthcare provider is advisable. They can offer guidance and make necessary adjustments to your treatment plan.

Pregnancy or Breastfeeding

The safety of using Pareglin during pregnancy or breastfeeding isn’t explicitly outlined in available sources. When it comes to medication use during these critical periods, it’s prudent to consult your healthcare provider. They can provide insights based on the latest research and your unique circumstances. Remember, altering medication usage without professional guidance is ill-advised.

Liver Health

Although Pareglin’s documentation doesn’t explicitly mention liver damage as a side effect, it’s essential to remain vigilant. Many medications, including its components, can potentially lead to liver issues, albeit rarely. If you experience persistent symptoms like nausea, stomach/abdominal pain, dark urine, yellowing of the eyes/skin, or unusual fatigue while using it, seek medical attention promptly.


In conclusion, Pareglin Tablet 2 Mg/500Mg is a valuable asset in the management of type 2 diabetes. Comprising repaglinide and metformin hydrochloride, it offers a dual approach to blood sugar control. However, your health remains paramount. This guide emphasizes the importance of consulting healthcare professionals for personalized guidance. Remember, it’s not a substitute for professional medical advice.

At a glance

Aspect Details
Product Pareglin Tablet 2 Mg/500Mg
Active Ingredients Repaglinide, Metformin Hydrochloride
Purpose Type 2 Diabetes Management
Usage Oral consumption before meals
Dosage Individualized based on regimen
Precautions Allergies, diabetes type, liver and kidney health
Side Effects Monitor for unusual symptoms
Onset of Action Repaglinide: Approximately 30 minutes; Metformin: Several days to weeks
Hypoglycemia Risk Common, recognize symptoms
Weight Management Potential for weight gain, individual responses vary
Pregnancy/Breastfeeding Consult healthcare provider
Liver Health Monitor for symptoms, seek medical attention if necessary


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The information on this page is not intended to be a substitute for professional medical advice, diagnosis, or treatment. always seek the advice for your physician or another qualified health provider with any questions you may have regarding a medical condition. Always remember to

  1. Ask your own doctor for medical advice.
  2. Names, brands, and dosage may differ between countries.
  3. When not feeling well, or experiencing side effects always contact your own doctor.


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