Description
Pantactive Enteric-Coated Tablet is a pharmaceutical product that contains Pantoprazole Sodium Sesquihydrate, equivalent to 20 mg of Pantoprazole. This medication is classified as a proton pump inhibitor (PPI), designed to suppress gastric acid production effectively. Its targeted action and enteric coating ensure precise delivery, enhancing its therapeutic value for managing acid-related gastrointestinal conditions.
Composition
Each enteric-coated tablet includes:
Active Ingredient: 21.146 mg of Pantoprazole Sodium Sesquihydrate, equivalent to 20 mg of Pantoprazole.
Enteric Coating: Protects the active ingredient from being dissolved in the stomach, ensuring it reaches the intestines for optimal absorption. This feature minimizes irritation to the stomach lining and improves overall efficacy.
Mechanism of Action
Pantoprazole works by inhibiting the proton pumps in the gastric parietal cells, which are responsible for secreting gastric acid. By blocking these pumps irreversibly, Pantoprazole significantly reduces acid production. This mechanism is particularly effective in conditions like gastroesophageal reflux disease (GERD), where excess stomach acid causes discomfort and damage to the esophagus.
Indications
Pantactive is prescribed for the following conditions:
Gastroesophageal Reflux Disease (GERD): Alleviates symptoms such as heartburn and acid regurgitation.
Prevention of Gastric Ulcers: Especially beneficial for patients on non-steroidal anti-inflammatory drugs (NSAIDs).
Reflux Esophagitis: Long-term management of inflammation caused by acid exposure in the esophagus.
Zollinger-Ellison Syndrome: Used in the management of pathological hypersecretory conditions.
Dosage and Administration
The recommended dosage guidelines for Pantactive include:
General Use: One 20 mg tablet daily before meals. Tablets must be swallowed whole with water, without crushing or chewing.
Severe Liver Impairment: Maximum dose is limited to 20 mg per day, with regular monitoring of liver function.
Duration of Treatment: The therapy duration depends on the condition being treated but typically ranges from 2 to 8 weeks.
Table: Key Information About Pantactive Enteric-Coated Tablet
| Category | Details |
|---|---|
| Composition | 21.146 mg Pantoprazole Sodium Sesquihydrate (equivalent to 20 mg Pantoprazole) per tablet. |
| Mechanism | Inhibits proton pumps, reducing stomach acid production. |
| Indications | GERD, reflux esophagitis, gastric ulcer prevention, Zollinger-Ellison syndrome. |
| Dosage | 20 mg daily before meals; special considerations for liver impairment. |
| Common Side Effects | Headaches, diarrhea, nausea, abdominal pain, flatulence, constipation. |
| Serious Side Effects | Severe allergic reactions, liver damage, kidney issues, Clostridium difficile infection. |
| Onset of Action | 1-2 hours for symptom relief, with effects lasting up to 24 hours. |
| Pregnancy Safety | Use only if necessary; consult a physician. |
| Drug Interactions | Caution with methotrexate, rilpivirine, and antifungal medications like ketoconazole. |
Pharmacokinetics
Pantoprazole exhibits the following pharmacokinetic properties:
Absorption: Rapidly absorbed, with peak plasma concentrations achieved within 2 to 2.5 hours post-administration.
Bioavailability: Approximately 77%, indicating effective systemic absorption after oral administration.
Protein Binding: Highly protein-bound (98%), contributing to its stable plasma levels.
Metabolism: Primarily metabolized in the liver by the cytochrome P450 enzyme system, particularly CYP2C19 and CYP3A4.
Excretion: Eliminated predominantly through urine, with minor fecal excretion.
Contraindications
Pantactive should not be used in the following scenarios:
- Allergies: Hypersensitivity to Pantoprazole or any excipients in the formulation.
- Severe Liver Dysfunction: Requires close medical supervision and dose adjustments.
- Combination with Rilpivirine: May reduce the efficacy of this antiretroviral medication.
Side Effects
Like all medications, Pantactive can cause side effects. Below is a categorized summary:
| Severity | Side Effects |
|---|---|
| Common | Headaches, diarrhea, nausea, abdominal pain, flatulence, constipation. |
| Less Common | Dizziness, dry mouth, mild skin rash or itching. |
| Serious | Severe allergic reactions (swelling, difficulty breathing), liver dysfunction (jaundice), kidney issues. |
| Long-Term Risks | Bone fractures (hip, spine, wrist) with prolonged use. |
Patients experiencing serious side effects should seek immediate medical attention.
Drug Interactions
Pantactive interacts with several medications, potentially altering their effects:
Major Interactions:
Methotrexate: May increase toxicity; dose adjustments are needed.
Rilpivirine: Contraindicated due to reduced efficacy.
Moderate Interactions:
Ketoconazole and Itraconazole: Reduced absorption due to decreased gastric acidity.
Warfarin: Potential changes in INR and bleeding risk.
Common Interactions:
Aspirin: Increases risk of gastrointestinal irritation.
Duloxetine: May require monitoring for additive effects.
Patients should inform their healthcare providers about all concurrent medications, including over-the-counter drugs and supplements.
Comparison With Other PPIs
Pantoprazole, the active ingredient in Pantactive, shares similarities with other PPIs but also has distinct characteristics:
- Efficacy: Comparable to omeprazole and lansoprazole in treating GERD and peptic ulcers.
- Onset of Action: Slower than omeprazole, with effects typically taking 1-2 hours.
- Safety: Associated with fewer drug interactions compared to omeprazole, especially with medications metabolized by CYP enzymes.
Special Considerations During Pregnancy and Breastfeeding
Pantactive should only be used during pregnancy if no alternatives are available, and the benefits outweigh potential risks.
- Pregnancy: Categorized as B3 by the Australian TGA, indicating limited human data but some fetal risks in animal studies.
- Breastfeeding: Pantoprazole is excreted in breast milk in small amounts, but consultation with a healthcare provider is recommended.
Missed Dose Guidelines
If a dose is missed:
- Take It Immediately: If not close to the next scheduled dose.
- Skip It: If the next dose is due within a few hours.
- Avoid Doubling: Never take two doses simultaneously to compensate for a missed one.
Conclusion
Pantactive Enteric-Coated Tablet is a highly effective medication for managing acid-related gastrointestinal disorders. Its targeted action, robust safety profile, and efficacy make it a valuable option in treating GERD, peptic ulcers, and related conditions. Proper administration, monitoring for side effects, and awareness of potential drug interactions are critical for ensuring optimal therapeutic outcomes. Always consult a healthcare professional for personalized advice regarding Pantactive’s use.
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