Panadol Migrestop Film Tablet

Description

Panadol Migrestop is a medication designed to alleviate pain and reduce fever. It combines three active ingredients to achieve these effects effectively:

1. Paracetamol: Provides both pain relief and fever reduction.
2. Acetylsalicylic Acid: Offers pain relief, fever reduction, and anti-inflammatory effects.
3. Caffeine: Acts as a mild stimulant, enhancing the effects of acetylsalicylic acid and paracetamol.

Panadol Migrestop Indications

Panadol Migrestop is indicated for use in adolescents aged 16 years and older, as well as adults, for the treatment of various conditions, including:

• Headaches
• Toothaches
• Acute migraine attacks
• Neuralgia (nerve pain)
• Musculoskeletal system pains
• Dysmenorrhea (menstrual pain)
• Pain accompanying common cold and related conditions

Dosage and Administration

The recommended dosage of Panadol Migrestop for adults aged 18 years and older depends on the condition being treated:

For Headaches:

• Initial dose: 1 tablet
• Additional doses: 1 tablet every 4-6 hours if needed
• For severe headaches: Up to 2 tablets, with a maximum of 2 tablets every 4-6 hours
• Episodic use for up to 4 days

For Migraines:

• Initial dose: 2 tablets
• Additional doses: 2 tablets every 4-6 hours if needed
• Episodic use for up to 3 days

Important Note:

• The maximum daily dosage should not exceed 6 tablets, which includes 1500 mg paracetamol, 1500 mg acetylsalicylic acid, and 390 mg caffeine.
• Always take the medication orally with a full glass of water.

Condition	Initial Dose	Additional Doses	Maximum Daily Dosage	Duration of Use
Headaches	1 tablet	1 tablet every 4-6 hours if needed	Up to 2 tablets every 4-6 hours	Episodic use for up to 4 days
Migraines	2 tablets	2 tablets every 4-6 hours if needed	Up to 3 days

Contraindications

Panadol Migrestop should not be used under the following conditions:

1. Allergy to paracetamol, acetylsalicylic acid, caffeine, or any other ingredients in Panadol Migrestop.
2. A history of asthma, urticaria, or acute rhinitis after taking acetylsalicylic acid or other nonsteroidal anti-inflammatory drugs (NSAIDs) like diclofenac or ibuprofen.

Side Effects

Although specific side effects of Panadol Migrestop are not listed, it’s crucial to be aware of potential side effects associated with its ingredients, particularly paracetamol. Common side effects of paracetamol may include:

• Nausea
• Vomiting
• Constipation
• Abdominal pain
• Diarrhea
• Indigestion

Rare side effects can include:

• Blood in stools or urine
• Fever with or without chills
• Severe lower back or side pain
• Skin issues like rashes, hives, or itching
• Sore throat
• Sores, ulcers, or white spots in the mouth
• Sudden decrease in urine output
• Unusual bleeding or bruising
• Unusual tiredness or weakness
• Yellowing of eyes or skin

In cases of overdose, symptoms may include diarrhea, increased sweating, loss of appetite, nausea or vomiting, stomach cramps or pain, and upper abdominal swelling or tenderness.

Mechanism of Fever Reduction

Paracetamol, also known as acetaminophen, reduces fever by affecting the hypothalamic heat-regulating center in the brain. During fever, a protein called pyrogen is produced, leading to an increase in the synthesis of prostaglandin in the hypothalamus. This raises the body’s temperature set point. Paracetamol acts as an antipyretic, inhibiting the synthesis of prostaglandin, thereby lowering the body’s temperature.

Pregnancy

Paracetamol is generally considered safe for short-term pain and fever relief during pregnancy. It’s recommended to use the lowest effective dose for the shortest duration necessary. While studies suggest potential associations between prenatal paracetamol exposure and certain developmental risks, no clear evidence establishes a direct link.

Conclusion

Panadol Migrestop film tablets offer effective relief from various types of pain and discomfort, thanks to their combination of paracetamol, acetylsalicylic acid, and caffeine. When used as directed and within recommended dosage limits, Panadol Migrestop can be a valuable tool for managing headaches, migraines, and related conditions. However, it’s essential to consult a healthcare provider before starting any new medication, particularly during pregnancy. Always prioritize safety and follow medical guidance for the best results