Oneptus Film Coated Tablet 24 Mg/26Mg

Oneptus, a remarkable film-coated tablet, holds within its core the dynamic duo of 24.3 mg sacubitril and 25.7 mg valsartan (as a sacubitril valsartan sodium salt complex). This powerful medication falls under the esteemed category of angiotensin receptor neprilysin inhibitors, working its magic by breaking down into two active substances: sacubitril and valsartan.

Dosage form

Pack size


24 Mg/26Mg



Generic Name (Ingredient)

Each Film-Coated Tablet Contains 24.3 Mg Of Sakubitrile And 25.7 Mg Of Valsartan (As Sakubitril Valsartan Sodium Salt Complex).

Assuming your emergency circumstances for this product, visit Urgent Quotation page. Besides, for any pharmaceutical questions, please ask us in the comments section.


The Crucial Role in Heart Failure

1. Empowering Against Chronic Heart Failure

Oneptus stands as a beacon of hope for adults combating a type of long-term (chronic) heart failure. By reducing the risk of death from heart disease and alleviating hospitalizations due to heart failure, Oneptus renders invaluable support.

2. Targeting Reduced Ejection Fraction

The true potential of Oneptus is most pronounced in patients grappling with a reduced ejection fraction of the left ventricle of the heart. This particular type of heart failure occurs when the heart weakens, hindering its ability to effectively pump blood to the lungs and the rest of the body. Symptoms of heart failure, including shortness of breath, fatigue, weakness, and ankle swelling, are met with relief through Oneptus.


Oneptus dosage is a carefully calibrated process, designed to optimize results while accommodating patient tolerances. The recommended starting dose of Oneptus is 49/51 mg, administered twice daily. After an initial period of 2-4 weeks, the dose should be doubled, eventually reaching the target maintenance dose of 97/103 mg twice daily, as per individual patient tolerances.


To ensure safe and effective usage, certain contraindications must be heeded. Oneptus should not be used concomitantly with an angiotensin-converting enzyme (ACE) inhibitor. If transitioning from an ACE inhibitor to Oneptus, allow a washout period of 36 hours between administrations of the two drugs. Adherence to these protocols is essential for optimal health outcomes.

Side Effects

eptus is subject to additional monitoring, and a vigilance triangle is in place to identify new safety information swiftly. By promptly reporting any side effects experienced, patients can actively contribute to ensuring the drug’s safety and efficacy. Information on how to report side effects can be found at the end of Section 4.

Mechanism of Action

tus ingeniously fuses the power of two active substances, sacubitril and valsartan, to create a formidable force against heart failure.

1. The Role of Sacubitril: Neprilysin Inhibition

Sacubitril operates as a neprilysin inhibitor, targeting an enzyme called neprilysin. By blocking neprilysin, sacubitril elevates the levels of substances in the body that aid in blood pressure and fluid balance control. This widening of blood vessels and reduction of fluid buildup eases blood pressure, relieving the strain on the heart.

2. The Impact of Valsartan: Angiotensin II Receptor Blocker

Valsartan exerts its prowess as an angiotensin II receptor blocker (ARB), countering the actions of a hormone called angiotensin II, which constricts blood vessels. By blocking angiotensin II, valsartan facilitates blood vessel relaxation and dilation, resulting in lower blood pressure and reduced strain on the heart.

Together, the harmonious collaboration of sacubitril and valsartan relaxes blood vessels, facilitating smooth blood flow, and alleviating the heart’s pumping effort.


Oneptus, the amalgamation of sacubitril and valsartan, stands as a potent guardian against chronic heart failure. Embrace its therapeutic benefits, diligently adhering to prescribed dosages and reporting any side effects to safeguard your well-being. With Oneptus as your ally, embark on a journey to enhanced heart health and an improved quality of life.


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The information on this page is not intended to be a substitute for professional medical advice, diagnosis, or treatment. always seek the advice for your physician or another qualified health provider with any questions you may have regarding a medical condition. Always remember to

  1. Ask your own doctor for medical advice.
  2. Names, brands, and dosage may differ between countries.
  3. When not feeling well, or experiencing side effects always contact your own doctor.


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