Olgen Plus Film Coated Tablet 20 Mg/12.5Mg

Olgen Plus, a film-coated tablet containing 20 mg of olmesartan medoxomil and 12.5 mg of hydrochlorothiazide, is a medication designed to combat hypertension. In this comprehensive guide, we will explore its active ingredients, indications, side effects, and crucial precautions.

Dosage form

Pack size


20 Mg/12.5Mg



Generic Name (Ingredient)

Olmesartan Medoxomil 20 Mg Hydrochlorothiazide 12.5 Mg

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Olgen Plus combines two active ingredients, olmesartan medoxomil and hydrochlorothiazide, to effectively lower high blood pressure. Olmesartan medoxomil belongs to the angiotensin II receptor antagonist class, relaxing blood vessels and reducing blood pressure. Hydrochlorothiazide, on the other hand, is a thiazide diuretic, increasing urine production to aid in blood pressure reduction.


Olgen Plus is primarily prescribed for the management of essential hypertension, which refers to high blood pressure without a known cause. It becomes particularly relevant when Olgen (olmesartan medoxomil) alone proves insufficient in controlling blood pressure.

Exploring Excipients

Apart from the active ingredients, Olgen Plus contains various excipients, including lactose monohydrate (from cow’s milk), microcrystalline cellulose PH 112, colloidal silicon dioxide, low hydroxypropyl cellulose, magnesium stearate, powder polyethylene glycol (PEG) 3350, talc, hydrolyzed polyvinyl alcohol, titanium dioxide (E171), talc-red iron oxide (E172), and yellow iron oxide (E172).

Understanding Contraindications

Olgen Plus is contraindicated for individuals hypersensitive to olmesartan medoxomil, hydrochlorothiazide, or any excipients within the medication. Additionally, it should not be used by those with anuria or individuals taking aliskiren with diabetes.

Olgen Plus Side Effects

As with any medication, Olgen Plus can lead to side effects, although not everyone experiences them. Common side effects, occurring in more than 1 in 100 people, may include dizziness, fatigue, headaches, flu-like symptoms, runny or stuffy nose, cough, bronchitis, back or joint pain, nausea, and indigestion. These side effects are often transient and tend to improve as the body adapts to the medication.

Serious Side Effects

Certain individuals may encounter serious side effects after using Olgen Plus. It is imperative to seek medical attention if you observe:

  • Blood in urine
  • Persistent and severe diarrhea accompanied by noticeable weight loss
  • Skin rash or reddish-purple spots beneath the skin (especially on black or brown skin)
  • Uncontrolled bleeding, bruising, bleeding gums, nosebleeds, or unusually heavy periods
  • Muscle weakness, numbness, tingling, irregular heartbeat, palpitations, nausea, and shortness of breath (indicative of elevated potassium levels in the blood)

Anaphylaxis: A Rare But Serious Reaction

In rare cases, Olgen Plus can trigger a serious allergic reaction known as anaphylaxis. Seek immediate medical assistance if you experience sudden swelling of the lips, mouth, throat, or tongue, rapid breathing, wheezing, choking sensations, skin, tongue, or lip discoloration, confusion, drowsiness, or dizziness.

Storage and Usage

Olgen Plus should be stored in its original packaging, beyond the reach of children, and at room temperature, below 25°C. Always adhere to the medication’s expiration date, ensuring its efficacy.

Duration of Action

The onset of diuresis with hydrochlorothiazide, one of Olgen Plus’s active components, typically occurs around 2 hours post-dose, with the peak effect emerging at roughly 4 hours. This effect lingers for approximately 6-12 hours. The combination of Olmesartan medoxomil and Hydrochlorothiazide within Olgen Plus produces additive reductions in blood pressure, with the magnitude increasing alongside the dose of each component.

Duration of Treatment

The duration of Olgen Plus treatment varies based on individual responses. It is imperative to maintain the prescribed regimen, even if you feel well. High blood pressure often exhibits no symptoms, making consistent medication vital. Physicians will monitor blood pressure and adjust treatment as necessary, so never discontinue Olgen Plus without consulting your doctor.

Pregnancy and Breastfeeding

Olgen Plus is not recommended during pregnancy due to potential risks. Olmesartan medoxomil can harm the developing fetus, particularly in the second and third trimesters. If pregnancy occurs while using it , discontinue the medication and consult your physician for alternative hypertension management.

Regarding breastfeeding, Hydrochlorothiazide, one of its active components, is excreted in human milk. Although it is unclear whether olmesartan medoxomil is also excreted, caution is advised. The decision to continue nursing or discontinue the drug should consider the drug’s importance to the mother, weighed against potential risks to the infant.

Addressing Pregnancy on Olgen Plus

If pregnancy occurs while taking Olgen Plus, immediate cessation of the medication is essential. Olmesartan medoxomil’s potential fetal harm necessitates prompt medical consultation for alternative blood pressure management strategies.


In conclusion, it offers a compelling solution for hypertension, skillfully merging olmesartan medoxomil and hydrochlorothiazide. Understanding its intricacies, side effects, and contraindications is paramount for safe and effective usage. Always consult your healthcare provider for personalized guidance on Olgen Plus and its suitability for your health needs.


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The information on this page is not intended to be a substitute for professional medical advice, diagnosis, or treatment. always seek the advice for your physician or another qualified health provider with any questions you may have regarding a medical condition. Always remember to

  1. Ask your own doctor for medical advice.
  2. Names, brands, and dosage may differ between countries.
  3. When not feeling well, or experiencing side effects always contact your own doctor.


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