Muscoflex Injection

Muscoflex is in the form of a 2 mL bulb and contains 4 mg of thiocolchicoside active ingredient. Each box has 6 bulbs of 2 mL.

Muscoflex mainly has muscle relaxant effectiveness. It is used in symptomatic treatment of acute painful muscle spasms associated with the musculoskeletal system.

Pack size


4 Mg/2Ml 6X2Ml



Generic Name (Ingredient)

Thiocolchicoside 4 Mg

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Dosage form

Muscoflex Solution for intramuscular injection, 4 mg/2 ml.


2 ml of the solution contain:
active substance – Thiocolchicoside 4 mg,
excipients: sodium chloride 16.8 mg, water for injection a sufficient amount of up to 2 ml.


Clear liquid of light yellow color.


Absorption: With intramuscular administration, Thiocolchicoside is rapidly distributed in the blood, the peak concentration in the plasma is reached after 15-45 min.
After one intramuscular injection at a dose of Thiocolcycoside 4 mg, the maximum plasma concentration is 61 ng / ml.
Distribution: Binding to proteins is 13%. Thiocolchicoside binds to albumin. The average apparent volume of distribution is 76 liters after one intramuscular injection at a dose of 4 mg.
Metabolism: Half-life is 2.5-5 h
Excretion: Approximately 20% of the dose taken is excreted in the urine in the form of unchanged metabolites, 75-81% is excreted in feces.


Muscoflex is a semi-synthetic muscle relaxant derived from the natural glycoside colchicoside.
The drug exhibits selective affinity for gamma-aminobutyric acid (GABA) and glisinergic receptors. Evidence of the activity of this muscle relaxant can be considered the result of direct activation of GABA receptors at the level of the spinal cord.

The glycynomimetic effect of Muskoflex can be observed at various levels of the nervous system, both with spasms of a local nature, and with spastic spasms of central origin.
It does not have a curare-like influence. Does not cause paralysis and does not inhibit breathing. In addition, the drug does not have any effect on the cardiovascular system.

Indications for use

Muscoflex is indicated to relieve pain of a spastic nature in:
– degenerative diseases of the spine (curvature, static diseases of the back);
– traumatological and neurological diseases;
– during rehabilitation after joint surgery.

Dosage and administration

One ampoule intramuscularly twice a day.
The recommended course of therapy is 3-5 days.

Side effects

  • Rarely: skin rash, swelling, allergic and pseudo-allergic reactions (allergic vasculitis), gastralgia, diarrhea;
  • Occasionally: hypotension, irritability and drowsiness (with intramuscular administration).


In the event of diarrhea, you can reduce the dose to one ampoule per day.
If unexpected effects occur, consult a doctor.


  • Hypersensitivity to thiocolchicoside or colchicines;
  • Muscle hypotension;
  • Mild paralysis;
  • Pregnancy and lactation;
  • Children’s age up to 14 years.


Drug interactions:
No drug interactions have been observed. You can not use drugs with similar properties.

Special instructions

The drug should be used with caution in renal failure.


There is no data on overdose. With symptoms of overdose, symptomatic and supportive treatment is carried out.

Dosage form

Solution for intramuscular injection 2 ml.
In the box of 6 ampoules with enclosed instructions.

Storage conditions

Store at room temperature below +25C, in its original packaging.
Keep out of reach of children!

Shelf life

2 years
Do not apply after the expiration date.

Conditions of release from pharmacies

By prescription

Producator: Bilim Pharmaceuticals AS (prod.: Idol Pharmaceuticals, Turcia)


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