Methotrexate Roger Bellon Tablet

(1 customer review)

Methotrexate, a disease-modifying anti-rheumatic drug (DMARD), is a powerful medication used to treat a variety of autoimmune and inflammatory conditions. This comprehensive overview delves into the intricacies of this medication, shedding light on its mechanism of action, therapeutic applications, administration, dosage, interactions, side effects, and precautions.

Dosage form

Pack size


2.5 Mg



Generic Name (Ingredient)

Each Tablet Contains 2.5 Mg Methotrexate. Wheat Starch, Levylite And Magnesium Stearate Are Also Found As Additives.

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How it Works

Methotrexate exerts its therapeutic effects by modulating the immune system’s activity. In certain conditions, the immune system can mistakenly attack the body’s own tissues, leading to inflammation and illness. it reduces this aberrant immune response, thereby alleviating the associated symptoms and preventing further damage.

Conditions Treated by Methotrexate

Methotrexate is widely prescribed for the management of various arthritic and related conditions, including:

  • Rheumatoid arthritis
  • Psoriatic arthritis
  • Reactive arthritis
  • Vasculitis
  • Enteropathic arthritis
  • Myositis
  • Systemic sclerosis

Additionally, it finds application in the treatment of pediatric conditions such as:

  • Juvenile idiopathic arthritis
  • Lupus (SLE)
  • Juvenile dermatomyositis
  • Vasculitis
  • Uveitis
  • Localized scleroderma

Administration and Dosage

Methotrexate can be administered in various forms, including tablets, liquid, or injections. The typical regimen involves taking the medication once a week, on the same day each week. Dermatologists often prescribe 2.5 mg strength tablets for certain conditions.

The dosage varies depending on the specific condition being treated and the patient’s individual characteristics. It is crucial to follow the prescribed dosage and schedule to ensure optimal therapeutic outcomes and minimize potential side effects.

Time to Onset of Action

The time it required to take effect can vary. For rheumatoid arthritis, patients may experience symptom improvement within 3 to 6 weeks, with continued improvement over the following 3 months. However, it is important to note that methotrexate treats the symptoms and reduces the risk of long-term joint damage, but it may take up to 12 weeks before noticeable improvements are observed.

If methotrexate treatment is discontinued, it typically takes 3 to 6 weeks for the effects to diminish and rheumatoid arthritis symptoms to reappear. it is intended for long-term use to manage symptoms and slow disease progression.

Interactions with Other Medications

It can interact with various medications, potentially affecting its efficacy or increasing the risk of side effects. Some notable interactions include:

– Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): These medications, such as ibuprofen and naproxen, can potentially impair kidney function, which is crucial for methotrexate elimination.
Antibiotics: Certain antibiotics may increase methotrexate levels in the body.
Folic Acid: Folic acid can interact with methotrexate, potentially affecting its effectiveness.
Proton Pump Inhibitors (PPIs): PPIs, such as esomeprazole and omeprazole, may increase methotrexate levels in the blood.
Other Medications: It can interact with various other drugs, including acitretin, asparaginase, chloramphenicol, leflunomide, cisplatin, azathioprine, sulfasalazine, retinoids, penicillins, phenytoin, probenecid, procarbazine, pyrimethamine, sulfa medications, and tetracyclines.

It is crucial to consult with a healthcare provider before starting or stopping any medication to ensure safe and effective treatment.

Common Side Effects

Like any potent medication, methotrexate can cause side effects. Some of the most common side effects include:

  1. Gastrointestinal Symptoms: Nausea, dyspepsia, and abdominal pain are frequently reported.
  2. Mouth Inflammation (Stomatitis): Methotrexate can cause inflammation and ulcers in the mouth, leading to discomfort.
  3. Blood Cell Count Changes: Leukopenia (low white blood cell count) can increase the risk of infections.
  4. General Weakness and Fatigue: Patients may experience a feeling of tiredness and weakness.
  5. Skin Reactions: Rashes and other dermatologic reactions may occur in some patients.

Monitoring for these side effects and consulting with a healthcare provider is essential for proper management and treatment adjustments, if necessary.

Long-term Effects

Long-term use of methotrexate can have various effects on the body, including:

1. Liver Function: Changes in liver function tests and fibrosis (scarring) may occur, although serious hepatotoxicity (liver damage) is rare. Regular liver monitoring and biopsies may be recommended.

2. Lung Problems: Methotrexate may increase the risk of lung problems, particularly at high doses. Rare but serious side effects, such as lung infections and pneumonitis, have been reported.

3. Sensitivity to Sunlight: Methotrexate can increase skin sensitivity to sunlight, leading to sunburn-like reactions. Appropriate sun protection measures are recommended.

4. Other Serious Side Effects: Methotrexate has been associated with serious side effects, including bone marrow suppression, gastrointestinal issues, liver and kidney problems, and skin reactions. Close monitoring and prompt medical attention are crucial.

It is essential to consult with a healthcare provider to understand the potential long-term effects and take necessary precautions during treatment.


To ensure safe and effective use of methotrexate, several precautions should be taken:

1. Allergies: Inform your healthcare provider about any known allergies to methotrexate or other medications.
2. Pediatric Use: Methotrexate is not approved for use in children, and appropriate studies have not been performed in this population.
3. Geriatric Use: No specific problems have been identified in the elderly population, but close monitoring is recommended.
4. Breastfeeding: Methotrexate can be harmful to breastfed infants, and alternative medications or discontinuation of breastfeeding may be necessary.
5. Drug Interactions: Consult with your healthcare provider before starting or stopping any medication to avoid potential interactions.
6. Serious Adverse Reactions: Closely monitor for adverse reactions affecting various organ systems, and discontinue methotrexate if necessary.
7. Third Space Fluid Collection: Fluid accumulation (e.g., pleural effusion, ascites) may delay methotrexate excretion and increase toxicity, requiring drainage before treatment.

By adhering to these precautions and maintaining open communication with healthcare providers, patients can maximize the benefits of methotrexate while minimizing potential risks.

Table: Key Information

Aspect Details
Side Effects Nausea, dyspepsia, abdominal pain, stomatitis, leukopenia, fatigue, skin reactions
Dosage Varies based on condition and individual factors; typically once-weekly administration
Benefits Treats autoimmune and inflammatory conditions, reduces disease progression
Usage Rheumatoid arthritis, psoriatic arthritis, vasculitis, juvenile idiopathic arthritis, and others
Interactions NSAIDs, antibiotics, folic acid, PPIs, various other medications
Precautions Allergies, pediatric use, geriatric use, breastfeeding, drug interactions, adverse reactions, fluid accumulation


In conclusion, methotrexate is a powerful disease-modifying anti-rheumatic drug that plays a crucial role in the management of various autoimmune and inflammatory conditions. By understanding its mechanism of action, therapeutic applications, administration, dosage, interactions, side effects, and precautions, healthcare professionals and patients can optimize treatment outcomes while minimizing potential risks. Ongoing communication and monitoring are essential for safe and effective therapy.

1 review for Methotrexate Roger Bellon Tablet

  1. sakib

    জরুরি ভাবে mtx 10 টেবলেট জার্মান লাগবে প্লিজ হেল্প

    • Medical Guidance Center

      Hello there, this is Wikikenko. I’m sorry to hear that you need methotrexate urgently. Methotrexate is a medicine that can treat certain types of cancer, psoriasis, and arthritis. It can have serious side effects and should be taken only as prescribed by your doctor.

      Do you have a prescription for methotrexate? If so, you can try searching for nearby pharmacies that may have it in stock. If not, you should contact your doctor as soon as possible to get one.

      Please note that I am not a medical professional and cannot give you medical advice. This is for informational purposes only. Always consult your doctor before taking any medication.

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