Levonidin Film Tablet 500 Mg

Levonidin is a broad-spectrum antibiotic that belongs to the group of drugs known as fluoroquinolones. It is available in the form of a film tablet, with each tablet containing 500 mg of the active ingredient, levofloxacin. The yellow, oblong tablets feature a notch on one side, allowing for easy dose adjustment.

Dosage form

Pack size


500 Mg


Recordati Ilac



Generic Name (Ingredient)

Levofloxacin 500 Mg (Equivalent To 512.30 Levofloxacin Hemihydrate)

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Active and Auxiliary Substances

The active substance in Levonidin is levofloxacin, which is equivalent to 512.30 mg of levofloxacin hemihydrate. The auxiliary substances included in the formulation are:

  • Microcrystalline cellulose
  • PVP K30 (polyvinylpyrrolidone)
  • Croscarmellose sodium
  • Magnesium stearate
  • HPMC (hydroxypropyl methylcellulose)
  • PEG 4000 (polyethylene glycol)
  • Titanium dioxide (E 171)
  • Talc
  • Yellow iron oxide (E 172)

These auxiliary substances serve various purposes, such as binding, disintegrating, lubricating, and coloring the tablet.

Mechanism of Action

Levonidin exerts its antibacterial action by inhibiting two essential bacterial enzymes: topoisomerase IV and DNA gyrase. These enzymes are required for DNA replication, transcription, repair, and recombination. By targeting these crucial processes, it effectively disrupts the bacterial DNA, leading to cell death.

Levonidin has demonstrated in vitro activity against a wide range of gram-negative and gram-positive microorganisms. It is considered a bactericidal agent, meaning it kills the bacteria rather than just inhibiting their growth.


Levonidin is used in the treatment of infections caused by bacteria that are sensitive to levofloxacin. These infections may include:

  • Acute sinusitis (inflammation of the air cavities within the facial bones)
  • Acute exacerbation of chronic bronchitis
  • Community-acquired pneumonia
  • Complicated urinary tract infections
  • Acute pyelonephritis (kidney infection)
  • Uncomplicated and complicated skin and soft tissue infections
  • Chronic bacterial prostatitis
  • Exposure to airborne anthrax bacteria

The specific indication and dosage of Levonidin will depend on the type and severity of the infection, as well as the sensitivity of the causative pathogen.

Usage and Dosage

Levonidin tablets are intended for oral administration and can be taken with or without food. The dosage will vary depending on the type and severity of the infection, as well as the sensitivity of the causative pathogen. It is essential to follow the dosage instructions provided by your healthcare provider.

Drug Interactions

Levonidin, like all medications, can interact with other drugs, food, and certain health conditions. These interactions can affect the way Levonidin works and increase the risk of side effects.

There are three main types of drug interactions:

1. Drug-drug interaction: This occurs when a medication reacts with one or more other drugs.
2. Drug-food/drink interaction: This happens when something you eat or drink affects a drug.
3. Drug-condition interaction: This occurs when you have a health problem that makes it risky for you to take certain medications.

While specific interactions with Levonidin are not listed, it is crucial to inform your healthcare provider about all the medications, supplements, and herbal products you are currently taking before starting it. This will help your healthcare provider identify any potential interactions and take appropriate measures to ensure safe and effective treatment.


Proper storage of Levonidin tablets is essential to maintain their effectiveness and prevent potential issues. Here are some general guidelines for storing it:

Store in a cool, dry place: Heat, air, light, and moisture can damage the medication. Avoid storing Levonidin in areas with high temperatures, such as near the stove, sink, or other hot appliances.
Avoid bathroom storage: The heat and moisture from the bathroom can negatively impact the medication. It’s best to store Levonidin in a cabinet or drawer away from the bathroom.
Keep in the original container: Always keep the medication in its original container. Avoid removing the tablets from the container, as this can expose them to moisture and other environmental factors.
Keep out of reach of children: Store Levonidin out of the reach and sight of children to prevent accidental ingestion or poisoning.
Check the expiration date: Regularly check the expiration date on the medication and discard any expired or unused tablets.

If you have any specific questions or concerns about the storage of Levonidin, it’s recommended to consult with your healthcare provider or pharmacist.

How to Take Levonidin Tablets

When taking Levonidin tablets, it’s important to follow the instructions provided by your healthcare provider. Here are some general guidelines:

1. Consistency: Try to take your Levonidin medication at the same time every day. This can help you establish a routine and ensure that the medication is consistently in your system.
2. With or without food: These tablets can be taken with or without food. However, certain foods, medications, supplements, and medical conditions may affect how well your body absorbs the medication.
3. Swallowing the tablet: Start by holding your chin up and your shoulders back as you place the tablet in your mouth. Take a medium-sized sip of water, then quickly tilt your head forward as you swallow the tablet. This technique can help you swallow the medication more easily.

Always follow the specific dosage instructions provided by your healthcare provider. If you have any questions or concerns about taking Levonidin, don’t hesitate to discuss them with your healthcare team.


The safety of any medication during pregnancy is a critical consideration. It’s essential to carefully weigh the potential benefits of Levonidin for the mother against the possible risks to the developing fetus.

Unfortunately, specific information about the safety of Levonidin during pregnancy is not readily available. Therefore, it is crucial to consult with your healthcare provider if you are pregnant or planning to become pregnant while taking Levonidin.

In general, certain medications can cause severe congenital disabilities and complications. It is essential to discuss all medications, supplements, and herbal products you are currently taking with your healthcare provider, especially if you are pregnant or planning a pregnancy.

Side Effects

Like all medications, Levonidin can cause side effects. While not everyone experiences these side effects, they may occur in some individuals. The most commonly reported side effects of Levonidin include:

  • Nausea
  • Constipation
  • Diarrhea
  • Headache
  • Dizziness
  • Trouble sleeping

It’s important to note that individual responses to medication can vary, and some people may experience side effects not listed here. If you experience any new or worsening symptoms while taking Levonidin, it’s crucial to contact your healthcare provider immediately.


To ensure safe and effective treatment with Levonidin, it’s important to consider the following precautions:

1. Adequate hydration: While taking Levonidin, it’s essential to drink an adequate amount of water to avoid the risk of crystalluria (the formation of crystals in the urine).
2. Regular check-ups: Regularly visiting your healthcare provider is necessary to monitor your progress and adjust the dosage if necessary.
3. Inform healthcare providers: Inform all of your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking Levonidin.
4. Dose adjustment: Dose adjustment may be necessary in the presence of renal (kidney) or hepatic (liver) insufficiency.
5. QTc-interval prolongation: Levonidin is associated with QTc-interval prolongation and should be used with caution in patients with other risk factors for prolongation, such as hypokalemia or concomitant medications.

By following these precautions and maintaining open communication with your healthcare provider, you can help ensure the safe and effective use.


In conclusion, Levonidin is a potent antibiotic used to treat a variety of bacterial infections. By understanding the active and auxiliary substances, mechanism of action, indications, usage, and potential interactions, healthcare providers and patients can make informed decisions about the appropriate use.

Additionally, adhering to proper storage guidelines, taking the medication as directed, and being aware of potential side effects and precautions can help optimize the treatment outcomes. As with any medication, it is crucial to consult with a healthcare provider for personalized guidance and to discuss any concerns or questions.


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The information on this page is not intended to be a substitute for professional medical advice, diagnosis, or treatment. always seek the advice for your physician or another qualified health provider with any questions you may have regarding a medical condition. Always remember to

  1. Ask your own doctor for medical advice.
  2. Names, brands, and dosage may differ between countries.
  3. When not feeling well, or experiencing side effects always contact your own doctor.


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