Glarin Sc Kullanim Icin Injection Solution Iceren Kalem

Composition

Each milliliter (mL) of the solution includes 100 U (equivalent to 3.64 mg) of insulin glargine. Each 3 mL cartridge contains 300 U (equivalent to 10.92 mg) of insulin glargine. The solution is clear and colorless.

Usage

Glarin Sc is intended for subcutaneous injection and should be administered once daily at the same time each day. The dosage and timing should be individualized according to the patient’s needs.

Precautions

Before using Glarin, consider the following precautions:

• Allergies: Do not use Glarin if you are allergic to insulin glargine or any other ingredient in the formulation.
• Instructions: Follow your doctor’s instructions regarding dosage, monitoring (blood and urine tests), diet, and physical activity.
• Hypoglycemia: If you experience very low blood sugar (hypoglycemia), follow the emergency instructions provided.
• Immunogenicity: Be aware of the potential for immunogenicity, which is the ability of a substance to provoke an immune response.

Side Effects

Report any side effects to your healthcare provider. Common side effects include:

• Injection Site Reactions: Redness, swelling, itching, or pain at the injection site.
• Hypoglycemia: Symptoms such as sweating, shaking, fast heartbeat, hunger, blurred vision, dizziness, or tingling in hands/feet.
• Allergic Reactions: Rare but serious allergic reactions, including rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, or trouble breathing.

Storage

Refer to the user manual for detailed storage instructions.

Comparison of Glarin with Other Diabetes Medications

Glarin vs. Rapid-Acting and Short-Acting Insulins:

Rapid-acting insulins (e.g., insulin lispro, insulin aspart) begin working within 15 minutes, peak around 1 hour, and last for 2 to 4 hours. These are often used during meals and for correcting high blood sugar levels. Short-acting insulins have a similar, slightly extended profile.

Glarin vs. Intermediate-Acting Insulins:

Intermediate-acting insulins (e.g., NPH insulin) start working within 1 to 3 hours, peak around 8 hours, and last for 12 to 16 hours. These are used for overnight blood sugar control and between meals.

Glarin vs. Long-Acting Insulins:

Long-acting insulins (e.g., insulin detemir, insulin degludec) provide a steady insulin level over 24 hours without a pronounced peak. Glarin, as a long-acting insulin, helps maintain stable blood sugar levels throughout the day and night.

Non-Insulin Medications

Non-insulin medications work by increasing insulin production, decreasing sugar production and release from the liver, blocking starch breakdown, slowing sugar absorption from the intestines, or increasing insulin sensitivity. In contrast, Glarin directly replaces the insulin the body would normally produce, facilitating the movement of sugar from the bloodstream into cells.

Common Side Effects of Glarin Sc

• Injection Site Reactions: Redness, swelling, itching, or pain.
• Low Potassium Levels: Symptoms include muscle cramps, weakness, and irregular heartbeat.
• Hypoglycemia: Symptoms include sweating, shaking, fast heartbeat, hunger, blurred vision, dizziness, or tingling hands/feet.
• Allergic Reactions: Serious allergic reactions may include rash, itching/swelling, severe dizziness, or trouble breathing.

Managing Hypoglycemia

Hypoglycemia, or low blood glucose, can occur due to various reasons such as skipping meals, excessive exercise, or overmedication. Here are the steps to manage hypoglycemia while using Glarin:

1. Check Your Glucose:
   • If your glucose is between 51-70 mg/dl, consume 15 grams of carbohydrates (e.g., glucose tablets, fruit juice).
   • If your glucose is below 50 mg/dl, take 30 grams of carbohydrates.
2. Wait and Check Again:
   • After 15 minutes, recheck your glucose levels. If still below 70 mg/dl, consume another 15 grams of carbohydrates.
3. Eat a Meal or Snack:
   • Within 30-60 minutes after treating low blood sugar, eat a meal or snack.

Managing Allergic Reactions

If you experience an allergic reaction to Glarin, follow these steps:

1. Stop Using the Medication: Discontinue use immediately.
2. Seek Immediate Medical Attention: Allergic reactions can be serious and require prompt medical intervention.
3. Manage Symptoms at Home: For mild symptoms, wash the affected area, apply hydrocortisone cream or calamine lotion, and use cool compresses.
4. Follow-Up Care: Consult your healthcare provider for monitoring and potential adjustments to your treatment plan.

Benefits of Glarin Sc Kullanim Icin Injection Solution Iceren Kalem

Glarin Sc offers several benefits for managing diabetes mellitus:

• Effective Blood Sugar Control: Replaces the insulin that the body would normally produce, helping to control high blood sugar levels.
• Long-Acting Insulin: Provides a steady release of insulin over 24 hours, maintaining stable blood sugar levels.
• Ease of Use: Administered subcutaneously, making it convenient for home use.

Comparison with Other Long-Acting Insulins

Glarin vs. Insulin Glargine 300 Units/mL (Gla-300):

Gla-300 is a newer form of insulin glargine with a prolonged pharmacokinetic and pharmacodynamic profile compared to Glarin. Studies suggest that Gla-300 may have a lower risk of nocturnal hypoglycemia while providing similar HbA1c control.

Glarin Sc Key Information

Glarin Sc Kullanim Icin Injection Solution Iceren Kalem provides an effective and convenient option for managing diabetes mellitus, offering stable blood sugar control with once-daily dosing. Always consult your healthcare provider for personalized advice and treatment adjustments.