Epanutin Ready Mixed Parenteral

(1 customer review)

Epanutin Ready Mixed Parenteral, a formulation of phenytoin sodium, is a highly effective anticonvulsant used for various medical purposes. Its mechanism of action involves regulating sodium ions across cell membranes, thereby stabilizing neuronal membranes and reducing seizure activity. In this article, we will explore the uses, dosage guidelines, and potential side effects of Epanutin Ready…

Dosage form

Pack size


250 Mg/5Ml



Generic Name (Ingredient)

Phenytoin Sodium 250 Mg

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Indications and Clinical Applications

Epanutin Ready Mixed Parenteral is primarily indicated for the following clinical scenarios:

Control of Status Epilepticus

One of the most critical applications of this intravenous formulation is the management of status epilepticus, a life-threatening condition characterized by prolonged or recurrent seizures without regaining consciousness between episodes. In such circumstances, prompt intervention with Epanutin Ready Mixed Parenteral can help control the seizures and prevent further neurological damage.

Seizure Prevention and Treatment in Neurosurgery and Head Trauma

Neurosurgical procedures and severe head injuries can increase the risk of seizures, which can have devastating consequences if left untreated. Epanutin Ready Mixed Parenteral plays a vital role in preventing and treating seizures that may occur during or following these medical interventions, providing crucial neuroprotection.

Management of Ventricular Arrhythmias

In certain cases, Epanutin Ready Mixed Parenteral may be employed to treat life-threatening ventricular arrhythmias or arrhythmias secondary to digitalis intoxication. When other antiarrhythmic treatments have been ineffective or cannot be used, this medication can offer a valuable alternative.

Administration and Dosage Considerations

Epanutin Ready Mixed Parenteral is administered parenterally, either through intravenous injection or infusion. The dosage is carefully determined by the healthcare provider based on the patient’s condition, age, and response to treatment. It is crucial to note that there is a relatively narrow therapeutic window between the desired therapeutic effect and potential toxic doses, necessitating close monitoring and precise dosing.

Prior to administration, the solution should undergo a thorough visual inspection for any particulate matter or discoloration. The medication should only be used if the solution remains clear and free of haziness or precipitate, ensuring its sterility and potency.

For intravenous infusion, Epanutin Ready Mixed Parenteral must be diluted in 50-100 ml of normal saline, with the final concentration of phenytoin in the solution not exceeding 10 mg/ml. This dilution step is essential to ensure proper administration and minimize the risk of adverse reactions.

The infusion mixture should be administered immediately after preparation and completed within one hour, without refrigeration. Continuous monitoring of the electrocardiogram and blood pressure is mandatory during the administration of this medication to detect and address any potential adverse effects promptly.

Precautions & Storage Considerations

Proper storage of Epanutin Ready Mixed Parenteral is crucial to maintain its efficacy and safety. The medication should be stored according to the manufacturer’s instructions, typically at controlled room temperature. If refrigerated or frozen, a precipitate may form within the solution, but this will dissolve again once the solution is allowed to stand at room temperature. However, it is imperative to use only a clear solution without any visible particulate matter or discoloration to ensure the integrity of the medication.

Epanutin Ready Mixed Parenteral should be used with caution in patients with hypotension and severe myocardial insufficiency, as phenytoin can exacerbate these conditions. Additionally, it is important to note that phenytoin is not effective for the treatment of absence (petit mal) seizures. If both tonic-clonic (grand mal) and absence (petit mal) seizures are present, combined drug therapy may be required.

Epanutin Ready Mixed Parenteral Side Effects

Like any medication, Epanutin Ready Mixed Parenteral may cause side effects in some patients. Common side effects associated with this medication include:

  • Headaches
  • Drowsiness, sleepiness, or dizziness
  • Nervousness, unsteadiness, or shakiness
  • Nausea or vomiting
  • Constipation
  • Sore or swollen gums
  • Mild skin rash

It is crucial for patients to report any unusual symptoms or side effects to their healthcare provider promptly. Regular monitoring and follow-up appointments are essential to ensure the safe and effective use of this medication.

Summary Table

Aspect Details
Active Ingredient Phenytoin Sodium
Indications – Control of status epilepticus
– Seizure prevention and treatment in neurosurgery and head trauma
– Management of ventricular arrhythmias
Administration – Intravenous injection or infusion
– Inspect solution for particulate matter and discoloration before use
– Dilute for infusion in 50-100 ml normal saline, not exceeding 10 mg/ml concentration
– Administer infusion within one hour, without refrigeration
– Continuous monitoring of electrocardiogram and blood pressure
Dosage Determined by healthcare provider based on patient’s condition, age, and response
Storage – Follow manufacturer’s instructions, typically controlled room temperature
– Precipitate may form if refrigerated or frozen, but will dissolve at room temperature
– Use only clear solution without particulate matter or discoloration
Precautions – Use with caution in patients with hypotension and severe myocardial insufficiency
– Not effective for absence (petit mal) seizures
Common Side Effects – Headaches
– Drowsiness, sleepiness, dizziness
– Nervousness, unsteadiness, shakiness
– Nausea, vomiting
– Constipation
– Sore or swollen gums
– Mild skin rash

Epanutin Ready Mixed Parenteral is a vital therapeutic option in the management of various neurological conditions, including status epilepticus, seizures associated with neurosurgery or head trauma, and certain ventricular arrhythmias. However, its administration requires careful consideration of dosage, storage conditions, and potential side effects. Patients should work closely with their healthcare providers to ensure the safe and effective use of this medication, with regular monitoring and follow-up appointments to address any concerns or adverse reactions promptly.

1 review for Epanutin Ready Mixed Parenteral

  1. Natia


    • Medical Guidance Center

      Hello Natia, this is WikiKenko,

      Would you please describe more about your statement, unfortunately we don’t know what do you mean by “4”.

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