Coregen Ha Sterile Kullanima Hazir Dolu Eklem Ici Injection

Coregen Ha Sterile Intra-Articular Injection is a medical product originating from Germany, manufactured by Phibio. The active ingredient in this product is Sodium Hyaluronate, with a potency of 36 mg/2.25 ml.

Dosage form

Pack size


36 Mg/2.25Ml 1X2.25Ml



Generic Name (Ingredient)

36 Mg / 2.25 Ml Sodium Hyaluronate

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Sodium Hyaluronate and Its Uses

Sodium Hyaluronate is a natural polymer that increases the viscosity and compressive force of the synovial fluid. It is primarily used in the treatment of osteoarthritis, as it is thought to stimulate tissue renewal. Osteoarthritis is a degenerative joint disease characterized by the breakdown of joint cartilage and underlying bone, leading to pain, stiffness, and decreased mobility. Sodium Hyaluronate is particularly recommended for use in osteoarthritis patients with chronic pain who can be monitored with non-surgical treatment options.

Mechanism of Action

The mechanism of action of Sodium Hyaluronate in the treatment of osteoarthritis is not fully understood, but it is believed to have several beneficial effects. First, it helps to restore the viscoelastic properties of the synovial fluid, which acts as a lubricant and shock absorber in the joint. By increasing the viscosity and elasticity of the synovial fluid, Sodium Hyaluronate can reduce friction and improve joint function.

Second, Sodium Hyaluronate may have anti-inflammatory properties. Inflammation is a key feature of osteoarthritis, and by reducing inflammation, Sodium Hyaluronate can help to alleviate pain and swelling in the affected joint.

Third, Sodium Hyaluronate is thought to stimulate the production of endogenous hyaluronic acid by synoviocytes (cells that line the inside of the joint capsule). This can help to maintain the integrity of the joint cartilage and prevent further degeneration.

Several clinical studies have demonstrated the efficacy of Sodium Hyaluronate in the treatment of osteoarthritis. A meta-analysis of 76 randomized controlled trials involving over 7,000 patients found that intra-articular Sodium Hyaluronate injections significantly improved pain and function compared to placebo or other treatments, with effects lasting up to 12 months.

Intra-Articular Injection Applications

Intra-articular injection applications, including corticosteroids, hyaluronic acid (HA), and collagen, have become widespread in the management of joint disorders like osteoarthritis. These injections are administered directly into the joint space to deliver the active agents where they are needed most.


Corticosteroids are a class of anti-inflammatory drugs that can be used to quickly relieve pain and restore joint function in patients with osteoarthritis. They work by reducing inflammation and swelling in the affected joint. Corticosteroid injections can provide rapid relief, with effects typically lasting for 1-3 weeks. However, their effects are short-lived, and repeated injections may lead to cartilage volume loss and other adverse effects. Therefore, caution is needed when using corticosteroid injections for the long-term management of osteoarthritis.

Hyaluronic Acid (HA)

Hyaluronic acid, such as the active ingredient in Coregen Ha, is a natural component of the synovial fluid and cartilage. It is thought to have several beneficial effects in the treatment of osteoarthritis, including:

  • Restoring the viscoelastic properties of the synovial fluid
  • Reducing inflammation
  • Stimulating the production of endogenous hyaluronic acid
  • Protecting and regenerating joint cartilage

Hyaluronic acid injections are particularly recommended for osteoarthritis patients with chronic pain who can be monitored with non-surgical treatment options. Several studies have shown that intra-articular HA injections can significantly improve pain and function for up to six months, with effects lasting up to 12 months.


Collagen is a structural protein that is a major component of joint cartilage. The use of intra-articular collagen injections in the treatment of osteoarthritis is still experimental and not yet recommended in the guidelines. However, some studies suggest that collagen application may improve pain and function in the long term and potentially delay the need for surgery. More research is needed to establish the efficacy and safety of collagen injections for osteoarthritis.

Administration of Coregen Ha Sterile Intra-Articular Injection

Coregen Ha Sterile Intra-Articular Injection is administered as an intra-articular injection by a healthcare professional in a sterile environment. The procedure typically involves the following steps:

1. Preparation: The skin over the joint is cleaned with an antiseptic solution to minimize the risk of infection.

2. Anesthesia: A local anesthetic may be applied to numb the area and reduce discomfort during the injection.

3. Injection: The healthcare professional will then inject the medication directly into the joint space. The needle is usually inserted at a specific angle and depth to ensure that the medication is delivered to the correct location.

4. Aftercare: After the injection, the patient may be advised to rest the joint for a short period of time. This allows the medication to be fully absorbed into the joint tissue.

It’s important to note that the exact procedure can vary depending on the specific joint being treated and the patient’s overall health condition. Therefore, it should always be performed under the supervision of a healthcare professional.

Precautions and Side Effects

As with any medical procedure, intra-articular injections can have potential side effects and risks. These may include:

  • Pain at the injection site
  • Infection
  • Allergic reactions to the medication

Patients should inform their healthcare provider of any medications they are currently taking, as some can interact with the injection and cause adverse effects. For example, anticoagulants (blood thinners) may increase the risk of bleeding or bruising at the injection site.

It’s also important to note that intra-articular injections should be used with caution in patients with certain medical conditions, such as:

  • Infection in the joint or surrounding tissues
  • Skin problems near the injection site
  • Bleeding disorders
  • Poorly controlled diabetes

In these cases, the healthcare provider may need to adjust the treatment plan or consider alternative options.

Benefits of Coregen Ha Sterile Intra-Articular Injection

The key benefits of Coregen Ha Sterile Intra-Articular Injection include:

1. Effective treatment for osteoarthritis: Sodium Hyaluronate, the active ingredient in Coregen Ha, has been shown to significantly improve pain and function in patients with osteoarthritis. Its effects can last up to 12 months, making it a valuable option for long-term management of the condition.

2. Direct delivery of the active agent: By administering the injection directly into the affected joint, the active agent is delivered where it is needed most, without the need to travel throughout the entire body. This can make the treatment more effective in some cases.

3. Fast-acting effects: Unlike oral medications that can take up to an hour to work, intra-articular injections like Coregen Ha produce an effect within 2-15 minutes, providing rapid relief for patients.

4. Potential use in erectile rehabilitation programs: Sodium Hyaluronate has also become an important part of erectile rehabilitation programs after radical prostatectomy (prostate removal due to cancer). It helps prevent muscle atrophy and preserves tissue integrity in the penis, possibly speeding up the return of spontaneous erection.

5. Proven safety: Intra-articular injection therapy has been in use since 1983 and has been proven as a safe treatment when appropriately prescribed. However, as with any medical treatment, there are potential risks and side effects that should be discussed with a healthcare provider.


Coregen Ha Sterile Intra-Articular Injection has certain contraindications, including medical conditions like hemoglobinopathy, bleeding diathesis, and idiopathic priapism, as well as factors like difficulty controlling the hands and uncontrolled high blood pressure.

Hemoglobinopathy is a group of blood disorders and diseases that affect red blood cells. Bleeding diathesis refers to a tendency to bleed excessively, which could be problematic when administering an injection. Idiopathic priapism is a condition characterized by persistent and painful erections, which is a contraindication due to the risk of further complications.

Difficulty controlling the hands due to neural issues or arthritis could make self-administration of the injection challenging. Uncontrolled high blood pressure could be exacerbated by certain medications used in the treatment of osteoarthritis.

It is important to note that the dosage and frequency of administration should be determined by a healthcare professional based on the patient’s specific condition and needs. Coregen Ha Sterile Intra-Articular Injection should always be used under the supervision of a healthcare professional.


In conclusion, Coregen Ha Sterile Intra-Articular Injection is a valuable option for the treatment of osteoarthritis, offering effective pain relief and improved joint function for up to 12 months. Its direct delivery and fast-acting effects make it a convenient choice for patients, while its proven safety record and potential use in erectile rehabilitation programs add to its appeal. However, as with any medical treatment, it is essential to discuss the potential risks and benefits with a healthcare provider before starting treatment.


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The information on this page is not intended to be a substitute for professional medical advice, diagnosis, or treatment. always seek the advice for your physician or another qualified health provider with any questions you may have regarding a medical condition. Always remember to

  1. Ask your own doctor for medical advice.
  2. Names, brands, and dosage may differ between countries.
  3. When not feeling well, or experiencing side effects always contact your own doctor.


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