Ayra Plus Tablet

Ayra Plus, a pharmaceutical marvel, combines the strengths of candesartan and hydrochlorothiazide to tackle the challenge of high blood pressure. Let’s embark on a journey to understand the dynamics of Ayra Plus and its role in managing hypertension.

Dosage form

Pack size


16 Mg/12.5Mg



Generic Name (Ingredient)

Kandesartan Cilexetil 16 Mg Hydrochlorothiazide 12.5 Mg

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The Active Ingredients

Ayra Plus comprises two dynamic components – candesartan and hydrochlorothiazide, each contributing distinct attributes to its therapeutic profile.

  • Candesartan: As an angiotensin receptor blocker, candesartan’s primary role is to hinder the action of a substance in the body responsible for tightening blood vessels. This action culminates in the relaxation of blood vessels, subsequently reducing blood pressure and enhancing the delivery of blood and oxygen to the heart.
  • Hydrochlorothiazide: Operating as a diuretic within the thiazide group, hydrochlorothiazide operates by diminishing the body’s water content through increased urine flow. This diuretic effect plays a pivotal role in reducing blood pressure.


Ayra Plus serves as a crucial player in the realm of hypertension management. High blood pressure, if left unattended, poses significant threats to the cardiovascular system, including the heart, arteries, brain, and kidneys. It can culminate in severe conditions such as strokes, heart failure, or kidney failure. Ayra Plus steps in to mitigate these risks and ensure blood pressure remains within a healthy range.

Mechanism of Action

  • Candesartan’s Role: Candesartan orchestrates its effects by inhibiting the action of a specific substance in the body, which typically causes blood vessels to constrict. By negating this action, candesartan induces relaxation in blood vessels, leading to lowered blood pressure. Furthermore, this relaxation enhances the flow of blood and oxygen to the heart.
  • Hydrochlorothiazide’s Contribution: Hydrochlorothiazide, on the other hand, employs its diuretic properties to regulate the body’s water content. This results in an increased flow of urine, ultimately contributing to the reduction of blood pressure.


The recommended dosage protocol for Ayra Plus is straightforward:

  • Dosage: A single tablet is taken once daily.
  • Anticipated Outcomes: Significant antihypertensive effects are typically observed within 4 weeks of commencing treatment.
  • Clinical Consideration: When deemed clinically appropriate, transitioning from monotherapy to Ayra Plus can be explored.

Interactions and Precautions

  • Contraindication: The combination of Candesartan cilexetil with aliskiren-containing medicine is contraindicated in patients with diabetes mellitus (type I or II) or moderate to severe renal impairment (GFR <60 mL/min/1.73m^2) and is not recommended in other patients.
  • Dose Titration: When transitioning from Hydrochlorothiazide monotherapy, dose titration is recommended to ensure optimal therapeutic outcomes.
  • Renal Health: Ayra Plus should not be used in patients with severe renal impairment (creatinine clearance <30 mL/min/1.73 m^2 BSA).
  • Liver Function: Dose titration is advised for patients with mild to moderate chronic liver disease. However, Ayra Plus is contraindicated in patients with severe hepatic impairment and/or cholestasis.

Packaging and Availability

Ayra Plus is conveniently available in two packaging options: a 28 tablet pack and a 90 tablet pack. These pharmaceutical gems can exclusively be acquired at pharmacies.

Ayra Plus Side Effects

While specific side effects of Ayra Plus may not be explicitly listed, it’s essential to acknowledge that all medications have the potential to induce side effects, which can vary from person to person. If you notice any unusual symptoms or health changes while taking Ayra Plus, promptly consult your healthcare provider. They possess the expertise to provide precise guidance based on your health history and existing conditions.

Always adhere to your prescribed medication regimen and don’t hesitate to seek clarification from your healthcare provider regarding any queries you may have about the medication.

Onset of Action

The onset of Ayra Plus’s antihypertensive effect is typically achieved within approximately 4 weeks of initiating treatment. Nevertheless, the exact timeframe can vary contingent upon individual health conditions and other influencing factors. It is advisable to engage in a consultation with a healthcare provider for personalized insights.

Dizziness or Lightheadedness Concerns

While specific side effects of Ayra Plus are not delineated in available sources, it is crucial to recognize that dizziness or lightheadedness can be common repercussions of numerous medications, particularly those employed in hypertension management.

This occurrence, often referred to as orthostatic hypotension, transpires when blood pressure experiences a transient drop upon standing quickly, leading to sensations of dizziness or lightheadedness. Individual responses to medication vary, implying that not all Ayra Plus users will encounter these side effects. Should persistent dizziness or lightheadedness manifest, consulting your healthcare provider is imperative. They can offer guidance grounded in your specific situation, which may encompass potential adjustments to medication or dosage.

Stomach Concerns

While the precise side effects of Ayra Plus remain unspecified in available sources, it is vital to acknowledge that various medications can potentially trigger stomach-related issues. These encompass symptoms such as abdominal cramps, diarrhea, constipation, nausea, and vomiting.

While some of these side effects may be commonplace, others could signify underlying concerns. If you are taking Ayra Plus and grapple with persistent stomach-related problems, reaching out to your healthcare provider is paramount. They can provide insights customized to your specific context, which might entail potential medication or dosage modifications.


In conclusion, Ayra Plus represents a formidable ally in the battle against hypertension. Comprising candesartan and hydrochlorothiazide, this medication takes a dual-pronged approach to blood pressure regulation. With prescribed dosages and adherence, Ayra Plus can offer significant antihypertensive benefits while necessitating vigilance in monitoring potential side effects. Always maintain open communication with your healthcare provider to optimize therapeutic outcomes and safeguard your well-being.

At a glance

Attribute Information
Active Ingredients Candesartan 16mg and Hydrochlorothiazide 12.5mg
Primary Functions Blood pressure management
Indications Treatment of high blood pressure (hypertension)
Mechanism of Action Candesartan – Angiotensin receptor blocker; Hydrochlorothiazide – Diuretic
Recommended Dosage 1 tablet once daily
Anticipated Effect Duration Most antihypertensive effect within 4 weeks
Availability 28 tablet pack and 90 tablet pack, sold in pharmacies


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The information on this page is not intended to be a substitute for professional medical advice, diagnosis, or treatment. always seek the advice for your physician or another qualified health provider with any questions you may have regarding a medical condition. Always remember to

  1. Ask your own doctor for medical advice.
  2. Names, brands, and dosage may differ between countries.
  3. When not feeling well, or experiencing side effects always contact your own doctor.


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