Omalizumab (Xolair) – A Treatment for Chronic Hives

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Omalizumab (Xolair) – A Treatment for Chronic Hives

Omalizumab (Xolair) – A Treatment for Chronic Hives

Chronic hives are a bothersome skin condition that affects millions of people worldwide. Despite being non-lethal, it can cause severe itching, and discomfort, and even affect one’s quality of life. Standard medications, including antihistamines and steroids, often fail to provide relief for patients. However, a new study suggests that Omalizumab (Xolair), a prescription drug used to treat allergic asthma, may offer relief to those suffering from chronic hives.

What is Omalizumab (Xolair)?

Omalizumab (Xolair) is a prescription drug that has been used for over a decade to treat moderate-to-severe allergic asthma. The drug works by targeting immunoglobulin E (IgE), a protein responsible for triggering allergic reactions. By reducing IgE levels in the blood, Omalizumab (Xolair) can prevent the onset of asthma symptoms.

Omalizumab (Xolair) for Chronic Hives

A recent study conducted by researchers confirms that high doses of Omalizumab (Xolair) can help control severe itching and other symptoms of chronic hives. The study involved more than 260 patients who had failed to respond to other treatments. Patients were randomly divided into four groups, with one group receiving a placebo and the other three receiving different doses of Omalizumab (Xolair).

Omalizumab (Xolair) – A Treatment for Chronic Hives
Omalizumab (Xolair) – A Treatment for Chronic Hives

Study Results

The study found that patients who received Omalizumab (Xolair) experienced a significant reduction in the overall number of hives, itching severity, and hive intensity compared to those who received the placebo. Approximately 40% of patients saw a complete disappearance of symptoms, while 80% experienced minimally important improvement. The positive effects of the treatment persisted for six months, and the group that received the highest dose of Omalizumab (Xolair) saw the most significant improvement.

Side Effects of Omalizumab (Xolair)

Side effects of Omalizumab (Xolair) were described as mild to moderate and included headaches, joint pain, sinus infection, and injection site reactions. While these side effects can take a toll on the patient’s life, particularly if left untreated, they can be managed. For instance, CBD oil can help relieve particular symptoms like headaches and joint pain. Patients interested in trying CBD oil for the first time should consult with their doctor first. It’s also essential to check if the medication is suitable for the patient’s medical condition.


In conclusion, Omalizumab (Xolair) appears to be a promising treatment for chronic hives, particularly for patients who have failed to respond to standard treatments. More research is needed to see how the drug performs over longer periods, but the initial results are encouraging. If you’re experiencing chronic hives and standard treatments aren’t helping, talk to your doctor to see if Omalizumab (Xolair) is right for you.


  • How are chronic hives usually treated?

    Chronic hives are typically treated with antihistamines, which work to reduce itching and swelling. Other treatments include avoiding triggers, wearing loose clothing, and taking cold showers or baths.

  • How does Xolair work to treat chronic hives?

    Xolair works by targeting a protein called IgE, which is involved in the body’s allergic response. By reducing the amount of IgE in the body, Xolair can reduce the severity of hives.

  • Can Xolair be used to treat other conditions?

    Yes, Xolair is also used to treat allergic asthma and chronic idiopathic urticaria, which is another type of chronic hives.

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