Thiocilline Deri Ointment

Description

Bacitracin: A Brief Overview

Bacitracin is a combination of at least nine bacitracins, with bacitracin A being the most prominent component, comprising 60-80% of commercially prepared bacitracin. The discovery of bacitracin dates back to 1945, when the bacillus that produces it was first isolated from the knee wound of a child named Margaret Tracy. Bacitracin received FDA approval on 29 July 1948.

The primary mode of action of bacitracin is its ability to inhibit the formation of the bacterial cell wall, ultimately leading to the bacteria’s death. Bacitracin also oxidatively cleaves DNA, which is an essential mechanism for the inhibition of bacterial growth. Bacitracin has a short duration of action when administered topically and must be applied every 3-4 hours. However, it is important to note that bacitracin is nephrotoxic when given intramuscularly and may cause renal failure.

Neomycin: A Comprehensive Overview

Neomycin is a potent aminoglycoside antibiotic derived from the metabolic products of Streptomyces fradiae. Neomycin is a complex comprising three components: neomycin A, B, and C. The most active components of neomycin are neomycin B, also known as framycetin, and neomycin C, the isomer of neomycin B. Neomycin A, or neamine, is a moiety that links two molecules of neomycin B and C together.

Neomycin exerts its bactericidal action by inhibiting bacterial protein synthesis, effectively suppressing the growth and survival of susceptible bacteria. The bactericidal activity of neomycin lasts for 48-72 hours following oral administration.

Uses of Thiocilline Deri Ointment

Thiocilline Deri Ointment is a versatile cream that can be used to treat a wide range of bacterial infections, including acne, bacterial infections of the intestine, empyema, eye infections, infected wounds, infection, inflammatory reactions caused by acne, ocular inflammatory disease, pneumonia, skin ulcers, corticosteroid-responsive dermatoses, and minor cuts or scrapes.

Conclusion

Thiocilline Deri Ointment is a powerful cream that is widely used to treat various bacterial infections, thanks to its active ingredients, bacitracin and neomycin sulfate. Bacitracin and neomycin work together to eradicate bacterial infections effectively, making Thiocilline Deri Ointment a reliable treatment option for a wide range of bacterial infections.