Sikloplejin Eye Drop

Sikloplejin is an ophthalmic solution known for its capacity to induce mydriasis (pupil dilation) and cycloplegia (temporary paralysis of the ciliary muscle) primarily for diagnostic purposes. Frequently employed by ophthalmologists, Sikloplejin prepares the eye for thorough examinations.

Dosage form

Pack size


%1 5Ml



Generic Name (Ingredient)

5 Ml Contains 0.050 G Of Cyclopentolate Hydrochloride.

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Mechanism of Action

Sikloplejin operates by obstructing the responses of the iris sphincter muscle and the ciliary body’s accommodative muscle to acetylcholine stimulation. This results in both mydriasis (dilation of the pupil) and cycloplegia (paralysis of accommodation). It belongs to the anti-muscarinic drug class, akin to atropine and scopolamine.


Diagnostic Excellence

The primary application of Sikloplejin lies in achieving mydriasis and cycloplegia, creating an optimal environment for diagnostic procedures. It is also employed in the treatment of Anterior Uveitis (AU), offering therapeutic benefits in addition to its diagnostic role.

Pain Management

In cases where ocular inflammation induces ciliary body spasms and ocular discomfort, Sikloplejin steps in as a temporary solution. By inducing cycloplegia, it alleviates pain, allowing patients to find much-needed relief.

Post-Surgery Support

Post-ocular surgery, maintaining the anterior chamber’s integrity is paramount. Sikloplejin is sometimes prescribed to rest the iris, ensuring proper healing and minimizing complications.

Managing Post-Operative Inflammation

Cycloplegic eye drops like Sikloplejin are valuable tools in managing inflammation following ocular surgery. Their anti-inflammatory properties contribute to the healing process.

Key Information at a Glance

Attribute Sikloplejin Eye Drops
Primary Use Mydriasis and Cycloplegia for Diagnostic Purposes
Active Ingredient Cyclopentolate Hydrochloride
Formulation Ophthalmic Solution
Dosage 1-2 drops, 40-50 minutes before the procedure
Side Effects Acute angle-closure glaucoma, raised intraocular pressure, burning sensation, systemic effects
Contraindications Angle-closure glaucoma, hypersensitivity reactions, shallow anterior chambers
Precautions Potential increase in intraocular pressure, discontinuation if adverse effects occur

Side Effects

Cautionary Notes

While Sikloplejin yields invaluable benefits, it’s crucial to recognize potential side effects and complications.

Acute Angle-Closure Glaucoma

One of the most critical concerns is the development of acute angle-closure glaucoma, a condition characterized by rapid intraocular pressure elevation. If left untreated, it can result in severe pain and permanent vision loss.

Elevated Intraocular Pressure

Raised intraocular pressure can occur during cyclopentolate therapy. This is a condition that requires monitoring and, if necessary, intervention to mitigate the effects. The application of pilocarpine, physostigmine, or isoflurophate can help reduce mydriasis.

Transient Burning Sensation

It’s worth noting that a transient burning sensation of the eye may occur, particularly with the 0.5% solution. This discomfort is typically short-lived.

Systemic Effects

Excessive drug absorption from mucosal surfaces or ingestion may lead to systemic effects. These can manifest as dry mouth (xerostomia), flushing, rapid heart rate (tachycardia), and urinary retention.

Administration Guidelines

Sikloplejin is administered through eye drops. For adults and children above one year of age, one to two drops are instilled in the eye(s). If necessary, a second drop can be applied five minutes after the first. It is crucial to administer the drops 40 to 50 minutes before the intended procedure. To minimize systemic absorption, gentle finger pressure should be applied to the lacrimal sac for two to three minutes following administration.

Contraindications and Precautions

It is vital to be aware of contraindications and precautions associated with Sikloplejin.


Sikloplejin should not be used in patients with angle-closure glaucoma or those with shallow anterior chambers. Extreme caution is advised when considering its use in patients, especially children, who have previously experienced severe systemic reactions to the drug or those with hypersensitivity to any component of a cyclopentolate formulation.


The medication may lead to an increase in intraocular pressure, which, if sustained, could result in irreversible vision loss. If patients experience eye pain, blurred vision, a rapid pulse, or dizziness, discontinuation is advised, and immediate medical consultation is imperative.


In conclusion, Sikloplejin Eye Drops are a valuable tool in ophthalmology, facilitating both diagnostics and therapeutic interventions. Their judicious use, guided by healthcare professionals, ensures patient safety and optimal ocular care. Always seek professional advice before using any medication to safeguard your vision and ocular health


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The information on this page is not intended to be a substitute for professional medical advice, diagnosis, or treatment. always seek the advice for your physician or another qualified health provider with any questions you may have regarding a medical condition. Always remember to

  1. Ask your own doctor for medical advice.
  2. Names, brands, and dosage may differ between countries.
  3. When not feeling well, or experiencing side effects always contact your own doctor.


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