Description
Indications
Idiopathic Pulmonary Fibrosis (IPF)
IPF is a progressive lung disease characterized by thickening, stiffness, and scarring of lung tissue. Ofev helps reduce further scarring and stiffness in the lungs.
Systemic Sclerosis-Associated Interstitial Lung Disease (SSC-ILD)
SSC is a rare autoimmune disease affecting connective tissue. When fibrosis occurs in the lungs (ILD), Ofev helps mitigate scarring and stiffness.
Other Chronic Fibrosing Interstitial Lung Diseases (ILD)
Besides IPF and SSC-ILD, Ofev is also used for other chronic fibrosing ILDs that exhibit a progressive phenotype.
How Ofev Works
Ofev inhibits specific enzymes (tyrosine kinases) involved in fibrosis. By reducing scarring and stiffness, it improves lung function.
Recommended Dose
One 100 mg capsule twice daily (total of 200 mg daily).
Timing and Administration
- Take capsules approximately 12 hours apart.
- Swallow capsules whole with water (do not chew).
- Recommended to take with food.
Safety and Risks
- Ofev can only be obtained with a prescription.
- Treatment should be initiated by a doctor experienced in relevant diseases.
- Risks associated with Ofev should be discussed with a healthcare professional.
Authorization and Availability
- Marketing Authorization Holder: Boehringer Ingelheim International GmbH
- Ofev underwent accelerated assessment due to its significance for public health.
Product Details
- Available Strengths: 100 mg and 150 mg capsules
- Therapeutic Area: Idiopathic Pulmonary Fibrosis (IPF)
Common Side Effects
While taking Ofev, some side effects may occur. These include:
| Side Effect | Incidence |
|---|---|
| Diarrhea | 62% |
| Nausea | 24% |
| Abdominal pain | 15% |
| Vomiting | 12% |
| Constipation | 12% |
| Weight loss | – |
Remember that these side effects are not exhaustive, and individual experiences may vary. If you encounter any of these symptoms, consult your healthcare provider promptly.
Can I take Ofev with other medications?
Ofev (nintedanib) interacts with 172 drugs, including both prescription and over-the-counter medications. Some commonly checked interactions include:
- Albuterol
- Amlodipine
- Aspirin
- Atorvastatin
- Benzonatate
- Duloxetine
- Eliquis (apixaban)
- Famotidine
- Furosemide (Lasix)
- Gabapentin
- Hydrochlorothiazide
- Levothyroxine
- Lisinopril
- Losartan
- Metformin
- Metoprolol
- Montelukast
- Multivitamin
- Mycophenolate mofetil (CellCept)
- Omeprazole
- Pantoprazole
- Potassium chloride
- Prednisone
- Rosuvastatin
- Tramadol
- Vitamin B12 (cyanocobalamin)
- Vitamin C (ascorbic acid)
- Vitamin D3 (cholecalciferol)
Always consult your healthcare provider before starting or stopping any medication, as specific risks and benefits should be discussed.
Conclusion
Ofev Soft Capsule 100 Mg is a medication used to treat specific lung conditions, including Idiopathic Pulmonary Fibrosis (IPF), Systemic Sclerosis-Associated Interstitial Lung Disease (SSC-ILD), and other chronic fibrosing Interstitial Lung Diseases (ILD).
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