Muscoril Capsule 8 Mg

Muscoril, available in a capsule form with 8 mg of the active ingredient Thiocolchicoside, is a pharmaceutical remedy renowned for its muscle relaxant properties along with anti-inflammatory and analgesic effects.

Dosage form

Pack size


8 Mg



Generic Name (Ingredient)

Thiocolchicoside 8 Mg

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Composition and Formulation

The composition of Muscoril capsules is meticulously crafted. Each capsule contains 8 mg of Thiocolchicoside as the active ingredient, accompanied by other ingredients, including lactose monohydrate sourced from cow’s milk, corn starch, magnesium stearate, and gelatin sourced from beef, which constitutes the capsule’s formulation.

How does Thiocolchicoside work in the body?

Thiocolchicoside, the pivotal element in Muscoril capsules, exerts its therapeutic influence by selectively binding to the GABA-A receptor. This binding process effectively prevents muscle contractions by activating the GABA inhibitory motor pathway.

It operates as a competitive GABA receptor antagonist and exhibits inhibitory effects on glycine receptors, akin in potency to nicotinic acetylcholine receptors. It is important to note that Thiocolchicoside, due to its potent convulsant activity, is not recommended for individuals prone to seizures.

Uses and Indications

Muscoril finds its application in the treatment of orthopedic, traumatic, and rheumatologic disorders. Specifically, it serves as an adjuvant drug for the treatment of painful muscle contractures and is indicated for use in acute spinal pathology among adults and adolescents aged 16 years and older. Moreover, studies have explored its potential in addressing muscle tone, stiffness, contractures, and soreness commonly experienced by athletes during sporting competitions.

Mechanism of Action

The active ingredient Thiocolchicoside, the cornerstone of Muscoril, demonstrates its therapeutic efficacy by selectively binding to the GABA-A receptor. This binding event effectively thwarts muscle contractions by activating the GABA inhibitory motor pathway. It functions as a competitive GABA receptor antagonist and demonstrates inhibitory effects on glycine receptors, exhibiting potency similar to that of nicotinic acetylcholine receptors.

Precautions and Contraindications

General Precautions

  1. Impaired Judgment and Drowsiness: Muscoril consumption may induce drowsiness, impaired judgment, and compromised motor functions. Therefore, individuals taking this medication are advised to abstain from engaging in activities demanding high mental alertness, such as driving or operating heavy machinery.


  1. Hypersensitivity: Individuals with known hypersensitivity to Thiocolchicoside or any component of Muscoril capsules should refrain from its use.
  2. Pregnancy and Lactation: Muscoril is contraindicated during pregnancy and lactation. Additionally, women of childbearing potential not using contraception should avoid its use.
  3. Children and Chronic Conditions: The use of Muscoril is contraindicated in children and for the treatment of chronic (long-term) conditions.

Regulatory Restrictions

In November 2013, the European Medicines Agency’s Committee on Human Medicinal Products (CHMP) recommended restrictions on the use of thiocolchicoside-containing medicines in the European Union (EU). These medicines are now recommended solely as an add-on treatment for painful muscle contractures resulting from spinal conditions in adults and adolescents aged 16 years or older.

Side Effects

Muscoril, containing Thiocolchicoside as its active ingredient, may lead to various side effects, including nausea, allergic reactions, and vasovagal reactions. In rare cases, more severe side effects such as liver injury, pancreatitis, seizures, blood cell disorders, severe cutaneous disorders, rhabdomyolysis, and reproductive disorders have been reported. It is essential to emphasize that not all individuals taking Muscoril will experience these side effects. However, if unusual symptoms manifest during its usage, prompt medical attention is advised.


The recommended dosage for Muscoril is 8 mg every 12 hours, totaling 16 mg per day. The treatment duration is generally limited to 7 consecutive days. However, the specific dosage may be adjusted based on individual conditions and responses to treatment. It is imperative to adhere to the healthcare provider’s instructions.

How long does it take to work?

Muscoril, featuring Thiocolchicoside as its active ingredient, possesses an elimination half-life of approximately 5-6 hours. This indicates that it takes around 5-6 hours for half of the drug to be eliminated from the body.

Nonetheless, the onset of action may fluctuate depending on individual factors such as age, metabolism, overall health, and other variables. It is vital to acknowledge that while the drug may initiate its action shortly after ingestion, noticeable relief from muscle stiffness and pain may necessitate a longer duration. Consulting a healthcare professional is always recommended for precise information.

Can I take Muscoril with other medications?

Muscoril, akin to many medications, can interact with certain other drugs. These interactions can modify the effects of Muscoril or the other involved medications, potentially increasing the risk of side effects. For instance, Muscoril may produce additive central nervous system (CNS) depressant effects when used concomitantly with other medications that themselves induce CNS depression, such as benzodiazepines, barbiturates, alcohol, sedatives, antidepressants, hypnotics, anxiolytics, phenothiazines, and other antipsychotics.

It is crucial to inform the healthcare provider about all medications in use, encompassing prescription and over-the-counter drugs, vitamins, and herbal supplements. They can provide guidance on potential drug interactions, ensuring a secure treatment regimen.

Muscoril Capsule 8 Mg Benefits

Muscoril Capsule 8 Mg, containing Thiocolchicoside as the active ingredient, delivers a range of benefits:

  1. Muscle Relaxation: Muscoril serves as a potent muscle relaxant, alleviating discomfort associated with acute, painful musculoskeletal conditions, encompassing rigidity, tension, stiffness, and muscle spasms.
  2. Anti-inflammatory and Analgesic Effects: This medication exhibits anti-inflammatory and analgesic properties, contributing to the reduction of inflammation and pain in various orthopedic, traumatic, and rheumatologic disorders.
  3. Treatment of Muscle Contractures: Muscoril is a valuable adjuvant in addressing painful muscle contractures.
  4. Beneficial for Athletes: Recent studies have explored the efficacy of Muscoril in addressing muscle tone, stiffness, contractures, and soreness experienced by athletes during sporting competitions.


In conclusion, Muscoril Capsule 8 Mg, with its therapeutic attributes and cautious usage, is a pharmaceutical asset for individuals experiencing musculoskeletal discomfort and various associated conditions. Nevertheless, it is crucial to approach its usage with due consideration of medical advice and adhere to prescribed guidelines for a safe and effective treatment journey


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The information on this page is not intended to be a substitute for professional medical advice, diagnosis, or treatment. always seek the advice for your physician or another qualified health provider with any questions you may have regarding a medical condition. Always remember to

  1. Ask your own doctor for medical advice.
  2. Names, brands, and dosage may differ between countries.
  3. When not feeling well, or experiencing side effects always contact your own doctor.


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