Methotrexate – Teva Injection Solution Iceren Vial

Methotrexate, a folate analog metabolic inhibitor, has long been a mainstay in the treatment of various neoplastic diseases. Teva Pharmaceutical Industries Ltd., a global pharmaceutical company, offers an injectable formulation of methotrexate, known as Methotrexate – Teva Injection Solution. This article delves into the composition, indications, administration, safety considerations, and potential interactions of this vital…

Dosage form

Pack size


50 Mg/2Ml 1X2Ml



Generic Name (Ingredient)

25 Ml Of Methotrexate Per Ml. Each Vial Is 2 Ml.

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Composition and Formulations

Methotrexate – Teva Injection Solution is available in three different strengths, each supplied in single-dose vials:

  • 25 mg/mL, 1 gram vial
  • 25 mg/mL, 50 mg vial
  • 25 mg/mL, 250 mg vial

Notably, the vial stoppers are free from natural rubber latex, and the product is preservative-free, ensuring optimal safety for patients.

Indications and Therapeutic Applications

Methotrexate Injection is indicated for the treatment of various neoplastic diseases in both adult and pediatric patients. Its therapeutic applications encompass:

  • Acute lymphoblastic leukemia, as part of a combination chemotherapy regimen
  • Prophylaxis and treatment of meningeal leukemia
  • Non-Hodgkin lymphoma
  • Osteosarcoma, as part of a combination chemotherapy regimen
  • Breast cancer, as part of a combination chemotherapy regimen
  • Squamous cell carcinoma of the head and neck, as a single agent

Warnings and Precautions

While methotrexate is a potent chemotherapeutic agent, it carries significant risks and precautions that must be carefully considered. Notably, it can cause embryo-fetal toxicity, including fetal death, and is therefore contraindicated during pregnancy in non-neoplastic diseases. Patients of reproductive potential are advised to use effective contraception during and after treatment.

Methotrexate Injection is also contraindicated in patients with a history of severe hypersensitivity reactions, including anaphylaxis. Formulations containing benzyl alcohol should be avoided in neonates, low-birth weight infants, and for intrathecal use due to the risk of severe central nervous system toxicity or metabolic acidosis.

Close monitoring for infections, bone marrow suppression, renal, hepatic, neurological, gastrointestinal, pulmonary, and dermatological adverse reactions is essential. Methotrexate Injection should be withheld or discontinued as appropriate in the event of serious adverse reactions.

Administration and Dosing

Methotrexate – Teva Injection Solution can be administered via various routes, including intravenous (IV), intramuscular (IM), subcutaneous (SC), and intrathecal injection. For subcutaneous administration, the injection is typically given in the stomach or thigh area, rotating injection sites to prevent skin problems.

Intrathecal administration involves injecting the medication into the spinal canal and is used to treat certain types of cancers, such as meningeal leukemia. It is crucial to note that only preservative-free Methotrexate Injection should be used for neonates, low-birth weight infants, and intrathecal administration.

The dosage and administration of Methotrexate Injection are tailored to the specific disease state, patient risk category, concurrent medications, treatment phase, and response to treatment. Consulting with a healthcare professional is essential for detailed instructions and monitoring.

Key Information at a Glance

Aspect Details
Indications – Acute lymphoblastic leukemia
– Meningeal leukemia
– Non-Hodgkin lymphoma
– Osteosarcoma
– Breast cancer
– Squamous cell carcinoma of the head and neck
Administration Routes – Intravenous (IV)
– Intramuscular (IM)
– Subcutaneous (SC)
– Intrathecal
Precautions – Embryo-fetal toxicity
– Severe hypersensitivity reactions
– Benzyl alcohol toxicity in neonates and low-birth weight infants
– Close monitoring for adverse reactions
Common Side Effects – Gastrointestinal symptoms (nausea, vomiting, diarrhea)
– Oral health issues (stomatitis)
– Hematological issues (leukopenia)
– General symptoms (fatigue, drowsiness)
– Dermatologic reactions (rash)
Interactions – Major interactions (e.g., acitretin, asparaginase, chloramphenicol)
– Moderate interactions (e.g., NSAIDs, PPIs)
– Minor interactions

Methotrexate – Teva Injection Interactions and Precautions

Methotrexate can interact with various medications, potentially affecting its efficacy, increasing the risk of side effects, or causing adverse reactions. Major interactions, where the combination should be avoided, include medications such as acitretin, asparaginase, chloramphenicol, leflunomide, and certain agents that can cause kidney or liver problems.

Moderate interactions, where the combination may be used under special circumstances, include nonsteroidal anti-inflammatory drugs (NSAIDs) and proton pump inhibitors (PPIs). Minor interactions, where the risk is minimal but alternative options may be considered, also exist.

It is crucial to consult with a healthcare professional before starting or stopping any medication while taking Methotrexate Injection.


Methotrexate – Teva Injection Solution is a vital chemotherapeutic agent used in the treatment of various neoplastic diseases. Its potent efficacy is accompanied by significant risks and precautions, necessitating close monitoring and adherence to administration guidelines.

By understanding its composition, indications, administration routes, potential interactions, and safety considerations, healthcare professionals can optimize patient outcomes while minimizing adverse effects. Ongoing research and clinical expertise will continue to refine the use of this powerful chemotherapeutic agent in the fight against cancer.


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The information on this page is not intended to be a substitute for professional medical advice, diagnosis, or treatment. always seek the advice for your physician or another qualified health provider with any questions you may have regarding a medical condition. Always remember to

  1. Ask your own doctor for medical advice.
  2. Names, brands, and dosage may differ between countries.
  3. When not feeling well, or experiencing side effects always contact your own doctor.


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