Description

Table of Contents

History

In 1997: Aldara was approved by the FDA as a treatment for external genital and perianal warts. 3M received the first approval.

In 2004: it was marketed by 3M as a treatment for superficial basal cell carcinoma.

In 2006: 3M sold its pharmaceutical business in America to Graceway and in Europe to Meda AB.

In 2011: the patent on imiquimod expired. Graceway declared bankruptcy and Medicis Pharmaceutical bought its branding and approvals.

In 2015: Imiquimod is available worldwide under many brands.

Medical Uses

This patient-applied cream is indicated for the treatment of

genital warts
superficial basal cell carcinoma
actinic keratosis
melanoma skin cancer

Mechanism of action

The active substance in Aldara cream is called Imiquimod; it is an immune-response modifier that uses the immune system to bring about its effect. When the cream is applied to the skin, it acts locally on the immune system, the body’s natural defenses and trigger the release of cytokines including interferon. Interferon is a protein; it helps to kill the viruses that cause warts or the abnormal cells in the skin that develop into skin cancer or keratoses.

Aldara Market

Media has bought exclusive European rights to a new formulation of imiquimod from Graceway Pharmaceuticals. This newly approved formulation in the US and Canada is 3,75% imiquimod topical cream that is indicated for the treatment of actinic keratosis (AK). Today, Meda markets a higher strength (5%) of Aldara in Europe. Sales of Aldara were approximately 500 MSEK in 2009 that exceed $360 million

E.Fougera & Co., a leading specialty pharmaceutical manufacturer, also announced it has received first generic approval from the FDA for Imiquimod Cream 5%; this cream is generically equivalent to Aldara® by Graceway Pharmaceuticals and substitutable for all indications.

Perrigo Company, a leading global healthcare supplier announced it received FDA approval from the FDA to manufacture and market Imiquimod Cream, 5%. They will vertically integrate this product with their own API. This product is the generic equivalent of Graceway Pharmaceuticals Aldara® Cream, 5%, a topical treatment for actinic keratoses on the face or scalp, superficial basal cell carcinoma, and external genital and perianal warts. Wolters Kluwer Health measured that Aldara ® had sales of approximately $382 million prior to generic market formation.

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Cyberchondria

The truth is that when we’re sick, or worried about getting sick, the internet won’t help.

According to Wikipedia, cyberchondria is a mental disorder consisting in the desire to independently make a diagnosis based on the symptoms of diseases described on Internet sites.

Why you can't look for symptoms on the Internet

If diagnoses could be made simply from a textbook or an article on a website, we would all be doctors and treat ourselves. Nothing can replace the experience and knowledge of specially trained people. As in any field, in medicine there are unscrupulous specialists, differences of opinion, inaccurate diagnoses and incorrect test results.