Gribo Cold

GRİBO COLD is a drug offered in PVC/aluminum foil blister packages containing 10, 24 and 30 tablets. GRİBO COLD contains ibuprofen and pseudoefedrin as the active ingredient. Ibuprofen, the active ingredient of GRİBO COLD, is a nonsteroidative anti-inflammatory drug with painkiller and fever-lowering properties. Pseudoefedrin is a decongright drug that serves to relieve fullness in…

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Generic Name (Ingredient)

Ibuprofen 200 Mg Pseudoephedrine Hydrochloride 30 Mg

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Gribo COLD 200 mg/30 mg tablet Taken orally.

Active ingredients : Each tablet contains 200 mg of Ibuprofen and 30 mg of Pseudoephedrine hydrochloride.

Auxiliary substances : Microcrystalline cellulose, modified corn starch, colloidal silicon dioxide, sodium starch glycolate, stearic acid.

Read this article carefully before starting to use this drug. Because it contains very important information for you.

  • Keep this instructions for use. You may need to read again later.
  • If you have any additional questions, please consult your doctor or pharmacist.
  • This drug is personally prescribed for you, do not give it to others. Even if other people’s symptoms are the same as yours, the drug can harm them.
  • During the use of this drug, when you go to the doctor or hospital, tell your doctor that you are using this drug.
  • Follow the instructions in this instruction.


DO NOT use GRİBO COLD in the following cases

Risks associated with the cardiovascular system

– it may cause an increased risk of potentially fatal thrombolic events, heart attacks and strokes. This risk may increase depending on the duration of use. Patients with cardiovascular disease or cardiovascular disease risk factors may have a higher risk.

– GRIBO COLD coronary artery should not be used in the treatment of pain before “bypass” surgery.

Risks associated with the digestive system

– it may cause serious undesirable effects that can be fatal, such as bleeding, scarring, stomach or intestinal punctures. These undesirable effects can occur at any time, with or without a pre-warning symptom. Elderly patients are at higher risk for these serious effects.


  • If you are hypersensitive to any substance contained in GRİBO COLD,
  • If you have severe liver disease,
  • If you have severe renal failure,
  • If you encountered asthma, urticaria or allergic type reaction during the use of acetyl salicylic acid (Aspirin) and other nonsteroidal anti-inflammatory drugs,
  • If you have an untreated stomach and twelve finger intestine ulcers,
  • If you have inflammatory bowel disease (ulcerative colitis, Crohn’s disease)
  • If you are in the late stages of pregnancy (from the 6th month),
  • If you are going to undergo coronary artery bypass surgery or have just had it,
  • If you have high blood pressure and coronary artery failure (narrowing of the vessel that feeds the heart),
  • If you have a bleeding or other active bleeding related to the brain vessels
  • If you are using a Monoamine oxidase inhibitor to treat your depression or mood disorder, or if you have used it in the last 14 days,
  • If you have severe heart failure (NYHA Class IV),
  • If you are using any of the drugs used to treat depression, blood pressure drugs containing atropine, alpha or beta blockers used to treat eye or intestinal disorders, blood clotting related drugs, drugs used to treat asthma, appetite suppressors, mochlorobemide used in mood disorders, ergotamine or metiserjite used to treat migraines, oxytocin that cause uterine contraction used during childbirth,
  • children under 12 years of age
  • If you are breastfeeding,
  • If your thyroid gland is working fast, if you have an increase in eye pressure, if you have diabetes,
  • If you have ureochromocytoma (a tumor in the adrenal glands, it can cause an increase in the amount of adrenaline).



If, you or your child, use GRİBO COLD,

Your doctor will decide.


  • Avoid using pain, fever and inflammation in combination with any of the effective drugs group.
  • If stomach pain occurs, stop using the drug and consult your doctor.
  • If you have a serious pre-existing gastrointestinal disorder or symptoms, bleeding, ulcers or devastation may develop, which can be serious at any time of treatment. Due to the bleeding that may occur, darkening of the stool color, blood coming from the mouth, indigestion symptoms may occur. Therefore, if you have serious gastrointestinal disorders such as ulcers, bleeding and devastation, your doctor will recommend that you start treatment with the lowest dose and use some preventive drugs (misoprostol or proton pump inhibitors) with it.
  • Do not continue to use GRİBO COLD in case of exfoliation of the skin, mucous damage or hypersensitivity observed on the skin, contact your doctor as soon as possible.
  • Use with caution in cases of hypersensitivity such as swelling of the face and throat, difficulty breathing, narrowing of the bronchi (asthma) and a breath as a result of allegia.
  • If bruising and decay occurs in your body for no reason, consult your doctor.
  • If colds, tremors and fever suddenly rise, weakness, headache and vomiting, or a feeling of stiffness in the back of your neck, contact your doctor immediately; because it’s some kind of brain

there may be symptoms of inflammation of the membrane (aseptic meningitis).

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  • As with other pain, fever and inflammation effective drugs, GRİBO COLD should be used with caution in patients with kidney disease.
  • As with other pain, fever and inflammation effective drugs, GRİBO COLD can cause elevations in some of your values in liver function testing. Caution should be taken against signs and symptoms indicating impaired liver function (nausea, weakness, napping, itching, jaundice, pain in the upper right part of the abdomen, symptoms such as a flu).
  • If you have a clotting disorder in your blood, as it reduces the clustering of platelets involved in clotting, prolonging the bleeding time, continue GRİBO COLD treatment under the control of a doctor.
  • If you develop visual impairment while using GRİBO COLD, have an eye examination.
  • Be careful when using GRİBO COLD if you have high blood pressure problems or heart failure against the risk of fluid retention caused by drugs that cause pain, fever and inflammation.
  • If you have a heart condition or a high risk of heart disease (e.g. high blood pressure, diabetes) or high cholesterol, do not exceed the specified daily dose if you smoke.
  • As with other pain, fever and inflammation effective drugs, GRİBO COLD can cause serious side effects such as hospitalization or heart attack or stroke that can result in death. Although serious cardiovascular events may occur without any stimulating symptoms, when symptoms and symptoms such as chest pain, shortness of breath, weakness, difficulty speaking are observed, consult your doctor.
  • Consult your doctor if there is an unexplained weight gain or payment symptom (swelling of the ankle).
  • do not use for more than 5 days.
  • use carefully if you are over 60 years old.
  • If you have prostate enlargement and urinary bladder dysfunction, you should use the drug carefully.
  • If you have Systemic Lupus Erythematosis (SLE), a connective tissue disease, consult your doctor before use.
  • It should be used with caution as there is a higher risk of serious side effects such as bleeding and puncture in the gastrointestinal tract, which can be fatal especially in the elderly.
  • If you are an athlete, you may test positive for doping.
  • Infrequently, sudden onset with drugs that stimulate the sympathetic system, including pseudoefedrin, can develop severe abdominal pain, nausea, vomiting and visual impairment. In case of the occurrence of these complaints, the treatment of pseudoefedrin should be discontinued immediately.
  • If you have previously been diagnosed with prolonged QT syndrome (a condition that can lead to serious heart arrhythmia and sudden death) and Torsades de Pointes (life-threatening irregular heart rhythm), you should use the drug carefully if you are suspected of having these diseases.

If these warnings apply to you, even in any period in the past, please consult your doctor.

Use of GRIBO COLD with food and drink

Its interaction with food and beverages has not been reported.


Consult your doctor or pharmacist before using the drug.

Gribo cold should not be used during pregnancy.

If you find that you are pregnant during your treatment, consult your doctor or pharmacist immediately.


Consult your doctor or pharmacist before using the drug.

Although it is known that ibuprofe passes into breast milk in very small amounts, pseudoefedrin passes in a significant amount to breast milk.

Gribo cold should not be used during breastfeeding.

Vehicle and machine use

Do not use vehicles or machines as dizziness may develop during the use of GRİBO COLD.

Some of the auxiliary substances contained in GRİBO COLD

No warning is required for any of the auxiliary substances contained in the content due to the way or dose of use.

Use in combination with other drugs

  • When high blood pressure is taken together with the drug; it can reduce the effects of blood pressure lowering.
  • Anticoagulants such as warfarin or heparin (drugs that prevent or delay blood clotting) may increase their anticoagulant effects.
  • Since the risk of side effects may increase, its use should be avoided in combination with other NSAIDs, including COX-2 inhibitors such as aspirin, naproxen, celecoxib, nimesulide.
  • When ginkgo bil oba (used for dementia and vascular obstructions) is used in combination with herbal extract, the risk of bleeding in the gastrointestinal tract may increase.
  • When used in combination with cortisone group drugs, the risk of ulcers and bleeding in the gastrointestinal tract may increase.
  • The excretion of aminoglycoside group antibiotics (e.g. gentamicin, canamisin, streptomysin) with urine may decrease and increase its undesirable effects.
  • When taken in combination with cholesetiramin (a resin that binds the bile acid), the effect of GRİBO COLD may be delayed.
  • When used in combination with deconstruction drugs (om.furosemide, thiazide), the diuretic effect may decrease and the risk of kidney disorders may increase.
  • When used in combination with cyclosporin and takrolimus, a drug that suppresses the immune system, the risk of kidney disorders may increase.
  • When used in combination with mifepriston (low drug), it causes a decrease in the effectiveness of mifepriston.
  • When used in combination with effective zidovudin to retroviruses including the human immunodeficiency virus (HIV), it can increase the risk of blood diseases.
  • When used in combination with lithium salting (used in mental illness), lithium blood levels may rise and related side effects may occur.
  • When used in combination with quinolon group antibiotics (e.g. siprofloxacin), the risk of severe rhythmic contraction (convulsions) may increase in all or some of the voluntary muscles.
  • When used in combination with heart glucosides (e.g. digoxin, digitoxin) used in heart failure, these drugs can affect the excretion of kidneys, increase blood levels and lead to heart rhythm disorder.
  • The risk of bleeding in the gastrointestinal tract may increase when used in combination with drugs (antithrombocyte agents, e.g. aspirin, dipiridamol klopidogrel) and selective serotonin reuptake inhibitors (e.g. fluoxetine, fluvoxetine, paroxetine, sertralin) used for depression.
  • Very rare hypoglycemia (decreased blood sugar) was observed when used in combination with sulfonilure therapy (used in the treatment of diabetes).
  • In particular, it should be considered to reduce the dose of ibuprofen when used in combination with drugs that inhibit CYP2C9 ,an enzyme that metabolizes drugs in the liver (e.g. vorikonazole, fluconazole).
  • GRİBO COLD’s nasal congestion-relieving drugs, tricyclic antidepressants (e.g. Amitriptilin, nortriptilin, imipramine and decipramine), appetite-relieving drugs and some nervous system
  • with stimulant drugs or MAOI (such as monoamino oxidase inhibitors: Mochlorbemide)


sometimes it can cause elevated blood pressure. Because the drug contains pseudoefedrin, it can partially reverse the effect of blood pressure-lowering drugs such as brethylium, betanidine, guanitidine, debrizokin, methyldopa and alpha and beta adrenegic blocker drugs. Its use in combination with moclobemid poses a risk of hypertensive seizures (severe blood pressure elevation).

  • Use in combination with ergot alkaloids (ergotamine and metasidegia; used to treat migraines) increases the risk of side effects.
  • Increases the risk of hypertension with oxytocin used to facilitate childbirth.
  • Ibuprofen and other pain, fever and inflammation-effective drugs may reduce the effect of drugs used to treat high blood pressure and increase the risk of kidney damage of ADE inhibitors used to treat high blood pressure.
  • For co-use, GRİBO COLD may increase blood levels and undesirable side effects of methotrexate (a drug used to treat cancer) and antidepressants (used to treat depression).

If you are currently using any prescription or over-the-counter medication or have recently used it, please inform your doctor or pharmacist about them.

How to use Gribo cold?

Instructions for appropriate use and dose/frequency of application:

In adults and children over the age of 12, it should be taken with a quantity of water in the form of 2 tablets orally as the starting dose and 1-2 tablets every 4 hours, if necessary.

It should not be taken more than 6 tablets per day unless recommended by the physician.

To prevent unwanted effects, use it at the lowest dose and as soon as your doctor deems necessary.

Application path and method:

GRIBO COLD is taken from the mouth with a glass of water.

Different age groups:

Use in children:

GRIBO COLD should not be used in children under the age of 12.

adult dose is applied in children 12 years and older.

Use in the elderly:

Adult dose is applied in the elderly. It should be used carefully in patients over 60 years of age.


Kidney/Liver failure: The use of GRİBO COLD should be avoided in patients with severe kidney and/or liver failure or, if necessary, used at a low dose under the control of a physician.

If you have any indication that the effect of GRİBO COLD is very strong or weak, talk to your doctor or pharmacist.

If you’ve used more GRİBO COLD than you should have:

If you have used more GRİBO COLD than you should have used, or if children have used this drug by accident, always consult a doctor or the nearest hospital for advice on the precaution and risk.

Symptoms include: it can include nausea, abdominal pain, vomiting (there may be bloody lines), headache, tinnitus, blurred consciousness and shaky eye movements. In high doses, drowsiness, chest pain, palpitations, loss of consciousness, convulsions (especially in children), weakness and dizziness, blood in the urine, feeling cold, respiratory problems were reported.

If you have used more than you should use from GRİBO COLD, talk to a doctor or pharmacist.

If you forget to use GRİBO COLD

Do not take double doses to balance forgotten doses.


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The information on this page is not intended to be a substitute for professional medical advice, diagnosis, or treatment. always seek the advice for your physician or another qualified health provider with any questions you may have regarding a medical condition. Always remember to

  1. Ask your own doctor for medical advice.
  2. Names, brands, and dosage may differ between countries.
  3. When not feeling well, or experiencing side effects always contact your own doctor.


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